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1782. [Specific folic-acid targeted photosensitizer. The first step toward intraperitoneal photodynamic therapy for epithelial ovarian cancer].
作者: H Azaïs.;C Frochot.;A Grabarz.;S Khodja Bach.;L Colombeau.;N Delhem.;S Mordon.;P Collinet.
来源: Gynecol Obstet Fertil Senol. 2017年45卷4期190-196页
Epithelial ovarian cancer (EOC) management remains association of debulking surgery in combination with platinum-based chemotherapy. Sixty percent of women with EOC considered in remission will develop recurrent disease. An option to improve the completion of cytoreductive surgery may be the use of photodynamic therapy to induce necrosis of peritoneal metastases. A limit of this technique was the toxicity induced by the lack of specificity of old-generation photosensitizer (PS) for tumor tissue if the light could not be specifically applied. To solve this problem, a solution is the design of selective PS. Folate receptor is a promising target for EOC targeted therapy. We present preclinical results concerning properties of a folic-acid targeted photosensitizer.
1783. [Outcomes of patients with breast cancer in function of their body mass index].
作者: L Boivin.;C Diguisto.;M Chas.;L Bédouet.;C Etienne.;F Arbion.;G Body.;L Ouldamer.
来源: Gynecol Obstet Fertil Senol. 2017年45卷4期215-223页
The aim of this study was to evaluate outcomes of patients with breast cancer in function of the body mass index (BMI).
1784. [Giant mesenteric lipoma in children: A case-report].
Mesenteric lipoma is an extremely rare disease in children. Fewer than 50 cases have been reported in the literature. Diagnosis is based on clinical examination, ultrasound, and computed tomography (CT). However, only the histological study of the specimen during laparotomy or laparoscopy can confirm the diagnosis. Thus, surgery, be it by laparotomy or laparoscopic, is both a means of exploration and treatment in mesenteric lipoma. We report on a case of giant lipoma of the mesentery in a 7-year-old girl presenting paroxysmal abdominal pain with a subocclusive syndrome lasting 1 week.
1785. [Multimodal imaging in primary intraocular lymphoma].
Vitreoretinal lymphoma is a serious disease with highly varied clinical presentations. The goal of this work is to identify the various presentations (clinical, imaging) in order to improve screening for this disease.
1787. [Choroidal metastasis from a lung adenocarcinoma treated by intravitreal injection of anti-VEGF and external beam radiotherapy: A case report].
Choroidal metastases of lung cancer are very uncommon. This localization should be suspected on blurred vision and confirmed with an ophthalmological examination. Its treatment is not entirely codified. We report a case of blurred vision secondary to bilateral choroidal metastasis in a patient with choroidal metastases from a lung adenocarcinoma, treated by intravitreal anti-vascular endothelial growth factor (VEGF) injection and external beam radiotherapy. According to a literature review, we analyzed the place of the targeted treatments used alone or combined with the radiotherapy.
1788. [Results of the Massive Open Online Course (MOOC) on cancer diagnosis and evaluation of its impact on the perception of the pathology specialty].
作者: Charlotte Gardair.;Guilhem Bousquet.;Cédric de Bazelaire.;Jaqueline Lehmann-Che.;Patricia de Cremoux.;Jeanne Tran Van Nhieu.;Maxime Battistella.;Marie Sockeel.;Julien Calvani.;Michel Peuchmaur.;Thierry Molina.;Jocelyne Gervais.;Emilie Moenaert.;Yohann Pottier.;Laurent Prévaut.;Karima Sekri.;Philippe Bertheau.
来源: Ann Pathol. 2017年37卷2期144-150页
The Massive Open Online Course (or MOOC) "Diagnostic Strategies Cancers", was hosted in autumn 2016 on the platform "France Université Numérique" and had two levels of learners: students in the field of health and biology and the general public. Of the 5285 learners in 81 different countries, 1237 (23%) were successfully certified. This MOOC was also integrated into the teaching program of medical students of Paris Diderot University and Paris 13 University. Using anonymous questionnaires before and after MOOC, it has been shown that pathology is less known than other medical specialties. Participation in this MOOC led to a marked improvement in participants' knowledge of the place and role of the pathologist in the diagnosis of cancers. Regarding the students who have followed the MOOC as part of their university course, their comments were very positive, but it is necessary to make substantial adjustments in the amounts and contents of the campus-based courses.
1789. [Epithelioid angiomyolipoma of the kidney: About one case and malignant features evaluation].
作者: Pierre-Marie Lavrut.;Philippe Paparel.;Myriam Decaussin-Petrucci.
来源: Ann Pathol. 2017年37卷2期182-187页
Renal epithelioid angiomyolipoma (E-AML) is a rare mesenchymal tumor of the kidney included in the family of tumor with perivascular epithelioid cell differentiation (PEComas) and is frequently associated with tuberous sclerosis complex. Since its clinical and radiological features are not specific, the diagnosis remained mostly pathological. Microscopically, E-AML demonstrate proliferation of more than 80% of epithelioid cells with atypia, often associated with necrosis, hemorrhage, mitotic activity and vascular invasion. Tumor's cells are immunohistochemically positive for melanocytic and smooth muscle markers. The pathologic prognostic predictors are not well known and the malignancy remained based on the identification of distant metastasis. We herein report a case of E-AML diagnosed in a 58-year-old woman and review analysis in the literature to discuss the prognostic indicators of malignancy useful for risk stratification of E-AML and to manage the patients.
1793. [An exceptional association between retroperitoneal dedifferentiated liposarcoma and well differentiated pericolonic liposarcoma: about a case].
Liposarcoma is an extremely rare malignant adipose mesenchymal tumor. World Health Organization classifies liposarcomas into five subtypes: well differentiated, myxoid, pleomorphic, dedifferentiated and mixed. The association between multiple and synchronous location of several subtypes of liposarcomas is exceptional. Only 34 cases have been reported in the literature. We report the case of synchronous association between retroperitoneal dedifferentiated liposarcoma and two small well-differentiated lipoma-like pericolic liposarcomas. Anatomopathological aspects, therapeutic options and prognostic factors of liposarcomas have been reviewed in this study.
1794. [The role of dermoscopy in the diagnosis of basosquamous carcinoma].
作者: Hakima Elmahi.;Asmae Lahlou.;Hanane Baybay.;Salim Gallouj.;Fatima Zahra Mernissi.;Fatima Zahra Reggad.;Taoufik Harmouch.
来源: Pan Afr Med J. 2016年25卷252页
Basosquamous carcinoma (BSC) is a rare skin cancer which has areas of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) and a transition zone between them. However, dermoscopic features of BSC are not well described in the literature, except for two studies. The aim of this case study was to better identify and clarify the role of dermoscopy in the diagnosis of BSC, although histological confirmation is necessary.
1795. [Primary intramuscular non-Hodgkin's lymphoma in young subjects: about a case and review of the literature].
作者: Soufya Majdoul.;Nabil Omari.;Youness Allali.;Reda Ghabri.;Nadia Benchakroun.;Mostafa Fadili.;Nezha Tawfiq.;Hassan Jouhadi.;Souha Sahraoui.;Mohamed Nechad.;Abdelatif Benider.
来源: Pan Afr Med J. 2016年25卷223页
Primary extra-ganglionic non-Hodgkin's lymphoma (NHL) is rare and its primary intramuscular location is exceptional, as it account for less than 0.5% of all patients. It generally affects men, with an average age of 70 years. Standard treatment is based on surgical excision combined with chemotherapy and radiation therapy. We report the case of a 31-year old patient presenting with muscular pseudotumoral syndrome at the level of the right leg. Histological examination showed intramuscular large B-cell non-Hodgkin's lymphoma. The patient underwent exclusive chemotherapy with complete remission.
1796. [Solitary bone plasmacytoma: about 3 cases and review of the literature].
作者: Karim Masmoudi.;Emna Elleuch.;Rim Akrout.;Mohamed Amine Mnejja.;Afef Feki.;Mariam Ezzeddine.;Sofiène Baklouti.;Ben Jemaâ.
来源: Pan Afr Med J. 2016年25卷219页
Solitary plasmocytomas are rare, accounting for less than 5% of all plasmocytes proliferations. Its diagnosis is based on the presence of localized tumor of monoclonal plasma cells cytologically identical to those of multiple myeloma, in the absence of other signs of a disseminated form. This study aims to carry out a retrospective study of three cases of solitary bone plasmocytomas associated with a detailed review of the literature describing the diagnostic, therapeutic and evolving characteristics of this rare entity.
1797. [Primary large cell neuroendocrine carcinoma of the breast: a rare tumor in humans].
作者: Fatima Safini.;Zineb Bouchbika.;Zineb Bennani.;Sara Belkheiri.;Hicham El Attar.;Nadia Benchakroun.;Hassan Jouhadi.;Nezha Tawfiq.;Souha Sahraoui.;Abdellatif Benider.
来源: Pan Afr Med J. 2016年25卷205页
Primitive large cell neuroendocrine tumor of the breast is an extremely rare entity. Less than ten cases have been reported in the literature. We report a new case of a 61-year old male patient presenting with locally advanced tumor of the right breast, immediately metastasized to the lungs and pleura, staged cT4bN1M1. The patient received eight cycles of Docetaxel-based chemotherapy every 21 days, with a good clinical and radiological response (>50%), followed by adjuvant tamoxifen with disease stabilization for 18 months. Immunohistochemistry is still essential to determine the neuroendocrine nature of this tumor. Treatment is not well codified due to the rarity of this type of cancer.
1798. [Pseudo-tumoral peritoneal tuberculosis mimicking ovarian cancer: an important differential diagnosis to consider].
作者: Mounir Moukit.;Fatimazahra Ait El Fadel.;Jaouad Kouach.;Abdellah Babahabib.;Mohammed Dehayni.;Driss Moussaoui Rahali.
来源: Pan Afr Med J. 2016年25卷193页
Peritoneal tuberculosis is a curable infectious disease that can simulate advanced ovarian cancer, leading to extensive and unnecessary surgical procedures commonly performed on women of reproductive age. We report a new case of pseudo-tumoral peritoneal tuberculosis in a 43-year old female patient with suspected ovarian cancer associated with peritoneal carcinomatosis. The diagnosis of peritoneal tuberculosis was based on exploratory laparotomy with extemporaneous histological examination. The patient responded well to anti-tuberculosis treatment according to 2ERHZ/4RH protocol.
1799. [Cervicothoracic cystic lymphangioma: about a case].
Cervicothoracic cystic lymphangiomas are rare benign tumors developing from sequestration of embryonic lymph sac which is gradually filled with lymph fluid. The diagnosis is based on clinical signs (laterocervical swelling) and imaging (ultrasound and CT scan), then confirmed by histology after surgery which constitutes the basis of treatment. We here report a case of cervicothoracic cystic lymphangioma and review of the literature.
1800. [Solitary necrotic nodule of the liver: about two cases].
作者: Zeineb Mzoughi.;Sana Ben Slama.;Dhouha Bacha.;Haifa Romdhane.;Rached Bayar.;Asma Sassi.;Ahlem Lahmar.
来源: Pan Afr Med J. 2016年25卷183页
Nodular liver lesions mainly consist of tumors. Solitary necrotic nodule of the liver is rare. Preoperative diagnosis is difficult. We report the case of a 43-year old woman undergoing surgery for the treatment of a rectal adenocarcinoma metastatized to the liver. Abdominal CT scan showed liver nodule mimicking liver metastasis. The second case is that of a 56 year-old man undergoing cholecystectomy in whom a liver nodule was detected intraoperatively. In both cases, liver nodule was subcapsular and was resected. Anatomopathological examination allowed the diagnosis of solitary necrotic nodule of the liver. Nonspecific necrotic nodule of the liver should be suspected in liver lesions, even in neoplastic context. Characterization using imaging studies and puncture biopsy of liver lesions can be useful.
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