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3422. [Clinical aspects and surgical treatment of carotid body tumors].
作者: M Gersdorff.;M Hamoir.;T Robillard.;P Jaumin.;J L Scholtes.;P Mathurin.;J Van Den Eeckhaut.
来源: Acta Otorhinolaryngol Belg. 1985年39卷6期907-23页
The authors report their experience of three cases of carotid corpuscle tumors: two are bilateral and pertaining to the same family, one of them is associated with a bilateral tympano-jugular glomus. First they review the epidemiology and definitions of such tumors and then they develop the various clinical aspects and differential diagnosis of these tumors. They insist on the necessity of a CT scan examination and of an angiography. They give their experience of the preoperative embolization of the tumour vessels. They expose various aspects of the surgical technique, pointing out the interest of a large access, the need of a regular surgery and the necessary collaboration between head and neck surgeons and vascular surgeons. Finally they discuss the opportuneness to operate bilateral glomic tumors.
3423. [Rearrangement of the proto-oncogene c-myc in fresh cells from Burkitt's leukemia (L3)].
作者: D Mathieu-Mahul.;A Bernheim.;R Berger.;M Mauchauffe.;G Flandrin.;C J Larsen.
来源: Nouv Rev Fr Hematol (1978). 1985年27卷3期157-61页
The presence of a rearrangement of the proto-oncogene c-myc was investigated in the DNA of fresh cells isolated from the blood of two patients with Burkitt's leukemia (L3), and from the node biopsy of a patient with Burkitt's lymphoma. Both samples from the L3 leukemia patients had the characteristic t(8;14) translocation, while the lymphoma specimen presented no abnormality of chromosome 8. Only one of the leukemic DNA's presented a rearranged c-myc pattern, with the breakpoint region located between the first and the second exon. The c-myc pattern of the two other patients appeared normal. The finding of a rearranged c-myc oncogene in fresh cells from a Burkitt's leukemia is direct evidence for the implication of c-myc in the disease whereas most of the rearrangements previously described have been found in cell lines established in culture.
3424. [Familial autosomal dominant epidermolytic palmo-plantar keratoderma and adenocarcinoma (study of 4 generations)].
作者: J Chevrant-Breton.;P Kerbrat.;B Le Marec.;D Guérin.
来源: Ann Dermatol Venereol. 1985年112卷10期841-4页 3425. [The dysplastic nevus syndrome].3426. [Type II multiple endocrine neoplasia (Sipple syndrome): study of a family].
作者: M Verdy.;A Lacroix.;W Sturtridge.;O Kuchel.;M Cadotte.;W Schürch.;J Cantin.;J P Cholette.;E Bolté.
来源: Union Med Can. 1985年114卷1期49-59页 3427. [An all-inclusive genetic theory for carcinogenesis?].
Authors summarized the chromosomal anomalies known in Leukemias Lymphomas and solid tumors. Break points are not random but corresponded to oncogenes localizations. A fondamental role in cancerogenesis is played by oncogenes.
3428. [Diagnostic approach to medullary and related thyroid gland cancers. Management].
In 80% of cases, the histological pattern of medullary carcinoma is well known. Further investigations are needed in atypical cases, such as immunohistochemistry and electronic microscopy. The authors emphasized different diagnostic methods with a special mention for cytological analysis.
3429. [Familial genitocolonic cancer syndrome].3430. [Cytogenetic study of peripheral blood lymphocytes in treated Hodgkin's disease patients. Prognostic value].3431. [Importance of case finding and the symptomatology of Gardner's syndrome].3433. [Cowden's disease. Syndrome of multiple hamartomas].
作者: J Flageat.;J L Vircens.;M Benameur.;A Sekkat.;L Bouhamama.;P J Metges.
来源: J Radiol. 1984年65卷10期701-4页
Cowden's disease is a phacomatosis (multiple hamartomas), which is a familial, hereditary, dominant autosomal affection presenting as typical buccolabial mucocutaneous lesions associated with digestive tract polyps. Differential diagnosis of the predominantly digestive form of the disease is polyposis. A new case of this rare disorder is reported, only 62 cases being documented in literature.
3434. [Association of familial hyperparathyroidism and Cushing's disease].
Five members of one family had been operated on for primary hyperparathyroidism. One of them also had Cushing's disease (i.e. pituitary tumor). An association between familial hyperparathyroidism and Cushing's disease is quite unusual. Such a combination of rare diseases is not fortuitous though; it probably is but a special type of multiple endocrine neoplasia.
3435. [Alpha 1-antitrypsin; new perspectives].3436. [Von Recklinghausen's neurofibromatosis and pregnancy and the puerperium].
On the basis of a personal case and a review of the literature, the authors describe the particular features of the association of neurofibromatosis and pregnancy. With the exception of a few severe forms of the disease, pregnancy is possible in the majority of patients with neurofibromatosis, although there is a risk of hypertension of pregnancy. The rate of abortion is a little higher than in the general population.
3437. [Cloning of human genes].
The fears concerning potential hazards of man made recombinant DNA have been dismissed and the burden of compelling unnecessary safety regulations has been cleared away. The deciphering of the entire human genome at the nucleotide level is no longer an impossible task. It is based upon the utilization of cloned fragments of DNA used as specific probes. The present catalogue of cloned human genes is still small, but it will expand rapidly in the near future. There are two categories of probes: those corresponding to know genes, and those consisting of random "anonymous" DNA sequences present in genomic libraries. The increasing number of cloned probes will allow us to saturate progressively the entire genome. Medicine will benefit from this progress, first of all with regard to pre-natal and post-natal diagnosis of some genetic diseases and in the field of cancer research.
3438. [Cytogenetics of B- and T-differentiated lymphoma: recent cases].3439. [Acute transformation of chronic myeloid leukemia: disappearance of the Philadelphia chromosome after autograft].
作者: J Reiffers.;B David.;P Bernard.;G Vezon.;G Marit.;J Moulinier.;A Broustet.
来源: Sem Hop. 1984年60卷16期1113-5页
Two patients with chronic granulocytic leukemia (C.G.L.) undergoing transformation were treated by high dose chemotherapy and total body irradiation followed by autografting of hematopoietic stem cells collected and cryo-preserved at the time of diagnosis. Recovery of hematopoiesis was characterized by disappearance of the Philadelphia chromosome in most metaphases. A new approach of the management of C.G.L. is discussed.
3440. [2nd malignant tumors in children. Study of 38 cases].
作者: O Oberlin.;A Bernard.;F Flamant.;O Hartmann.;C Kalifa.;C Patte.;D Sarrazin.;M F Tournade.;J Lemerle.
来源: Arch Fr Pediatr. 1984年41卷4期241-8页
Thirty-eight children, followed in the pediatric Department of Institut Gustave-Roussy, developed second malignant neoplasms. Intervals between the two neoplasms ranged from 1 to 26 years. The second neoplasms were defined as having a different histologic diagnosis than the first ones: osteosarcoma, fibrosarcoma, thyroid carcinoma, leukemia were the most frequent second neoplasms. The potential carcinogenic part of chemotherapy and radiotherapy is emphasized. In addition, some genetic susceptibility may enhance the carcinogenic effects of therapy. Nevertheless the incidence of second malignant neoplasms is low. Its estimation is discussed here.
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