"Ann Intern Med"[journal] 检索结果

1. In postmenopausal women at high risk for fracture, romosozumab for 3 mo was noninferior to 12 mo for increasing total hip BMD at 1 y.

作者: Yu Qing Huang.;Jennifer Watt.; .
来源: Ann Intern Med. 2026年179卷5期JC52页

Geriatrics:[Formula: see text] Rheumatology:[Formula: see text].

2. In adults with ADHD, atomoxetine, methylphenidate, and CBT reduce symptom severity and the drugs are less tolerable vs. control at 12 wk.

作者: Gary M Onady.; .
来源: Ann Intern Med. 2026年179卷4期JC39页

Mental Health:[Formula: see text] GIM/FP/GP:[Formula: see text].

3. The Effect of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID : An Adaptive Randomized Trial.

作者: Gilmar Reis.;Eduardo Augusto Dos Santos Moreira Silva.;Daniela Carla Medeiros Silva.;Lehana Thabane.;Thiago Santiago Ferreira.;Luiza Lanna França Reis.;Ana Paula Figueiredo Guimaraes Almeida.;Marcela Menezes Amaral.;Leonardo Cançado Monteiro Savassi.;Vitoria Helena de Souza Campos.;Maria Izabel Campos Simplicio.;Luciene Barra Ribeiro.;Thalyne de Souza Medeiros.;Thais Campos Siqueira.;Taynara Silva Vieira.;Nayara Drumond Rausse.;Tereza Cristina Garofolo.;Eliane Carreiro Fagundes Silva.;Ofir Harari.;Gennaro D'Urso.;Jamie I Forrest.;Jay Park.;Jean B Nachega.;Christopher Lindsell.;Jeffrey S Glenn.;Kristian Thorlund.;Mark Dybul.;Edward J Mills.; .
来源: Ann Intern Med. 2026年179卷5期621-628页

Postacute sequelae of SARS-CoV-2, or long COVID, presents a major therapeutic challenge, with fatigue being a prevalent and debilitating symptom.

4. Timing of Pegfilgrastim Administration and Pegfilgrastim-Induced Bone Pain : A Prospective, Randomized, Phase 3 Trial.

作者: Peiyong Li.;Yitian Chen.;Yingyi Lin.;Xiaoqi Zhang.;Minyi Cheng.;Teng Zhu.;Hong-Fei Gao.;Liulu Zhang.;Jieqing Li.;Na Huang.;Yilin Chen.;Minting Liang.;Yuanqi Zhang.;Shengchao Huang.;Junqiu Zheng.;Cangui Wu.;Ciqiu Yang.;Kun Wang.
来源: Ann Intern Med. 2026年179卷5期656-665页

Pegfilgrastim-induced bone pain (PIBP) is common and lacks effective treatment.

5. Neither Metformin nor Ursodeoxycholic Acid Effectively Treats Postacute Sequelae of COVID-19 : A Randomized Clinical Trial.

作者: So Yun Lim.;Jacob Lee.;Euijin Chang.;Ji-Soo Kwon.;Choi Young Jang.;Yubin Seo.;Jin Ju Park.;Sun Hee Na.;Hyejin Park.;Hyeon Mu Jang.;Sung-Cheol Yun.;Sung-Han Kim.
来源: Ann Intern Med. 2026年179卷4期478-485页

There is no proven treatment to alleviate symptoms of postacute sequelae of SARS-CoV-2 infection (PASC), despite its substantial public health burden.

6. Stable Supportive Footwear for Self-managing Hip Osteoarthritis Pain : A Randomized Clinical Trial.

作者: Kade L Paterson.;Kim L Bennell.;Ben R Metcalf.;Fiona McManus.;Karen E Lamb.;Jesse Pardo.;Sarah Jones.;Rana S Hinman.
来源: Ann Intern Med. 2026年179卷4期469-477页

Few effective nonsurgical treatments exist for hip osteoarthritis. Footwear influences hip forces and may be a promising novel approach.

7. Effect of Social Vulnerability on Efficacy of Bariatric Surgery Versus Medical and Lifestyle Intervention for Type 2 Diabetes: Analysis of the ARMMS-T2D Consortium of Randomized Trials.

作者: Mary Elizabeth Patti.;Bo Hu.;Sarah Kirschling.;Hanna J Wang.;Kathleen Foster.;Yael Sarig.;Donald C Simonson.;Danielle Wolfs.;David Arterburn.;Matthew J O'Brien.;Ashley H Vernon.;John M Jakicic.;Lori Laffel.;Sando Ojukwu.;Sangeeta R Kashyap.;Ali Aminian.;Philip R Schauer.;David E Cummings.;William F Gourash.;Anita Courcoulas.;John P Kirwan.
来源: Ann Intern Med. 2026年179卷3期353-361页

Social determinants of health (SDOH) can affect metabolic health.

8. Once-Weekly Oral Islatravir Plus Lenacapavir Versus Daily Oral Bictegravir, Emtricitabine, and Tenofovir Alafenamide in Persons With HIV-1 : A Phase 2 Randomized Study.

作者: Amy E Colson.;Gordon E Crofoot.;Peter J Ruane.;Moti N Ramgopal.;Alexandra W Dretler.;Ronald G Nahass.;Gary I Sinclair.;Mezgebe Berhe.;Afsoon Roberts.;Shauna Applin.;Cynthia Brinson.;Dushyantha Jayaweera.;Kimberly A Workowski.;Fadi Shihadeh.;Shan-Yu Liu.;Stephanie Klopfer.;Cyril Llamoso.;Sharline Madera.;Hadas Dvory-Sobol.;Martin S Rhee.;Elizabeth G Rhee.;Jared M Baeten.;Joseph J Eron.
来源: Ann Intern Med. 2026年179卷2期168-176页

Once-weekly oral islatravir plus lenacapavir (ISL+LEN) has the potential to address adherence challenges with daily HIV-1 treatment.

9. Integrating Methadone Services Into Primary Care in Ukraine: Two-Year Outcomes From a Randomized Trial.

作者: Eteri Machavariani.;Denise Esserman.;Kostyantyn Dumchev.;Myroslava Filippovych.;Iryna Pykalo.;Roman Ivasiy.;Lynn M Madden.;Daniel J Bromberg.;Marwan Haddad.;Olga Morozova.;David Oliveros.;Bachar Ahmad.;Sergii Dvoriak.;Frederick L Altice.
来源: Ann Intern Med. 2026年179卷2期177-186页

Opioid use disorder (OUD) drives high morbidity and mortality, but access to opioid agonist therapy (OAT) is limited in low- and middle-income countries. Integrating OAT into primary care may expand access and improve comorbidity management, although provider discomfort remains a barrier.

10. In older adults living in rural China, a primary care-based fall prevention program vs. usual care reduced self-reported falls at 1 y.

作者: Eric K C Wong.;Jennifer A Watt.; .
来源: Ann Intern Med. 2025年178卷12期JC143页

GIM/FP/GP: [Formula: see text] Geriatrics: [Formula: see text].

11. Interventions to Improve Advance Care Planning Documentation in the Electronic Health Record : A Cluster Randomized Trial.

作者: Anne M Walling.;Rebecca L Sudore.;Lisa Gibbs.;Maryam Rahimi.;Ron D Hays.;Chi-Hong Tseng.;Kanan Patel.;Katherine Santos.;Fernando Javier Sanz Vidorreta.;Aaron J Chau.;Juan Carlos Antonio Lopez.;Jamie Anand.;G Rick Marshall.;Anna DePaolis-Dickey.;Kirsten I Buen.;Douglas S Bell.;Christine S Ritchie.;Victor Gonzalez.;Neil S Wenger.
来源: Ann Intern Med. 2026年179卷1期42-50页

Advance care planning (ACP) can improve communication of patients' preferences but is underutilized in health systems.

12. In older adults at risk for dementia, a structured vs. self-guided lifestyle intervention improved cognitive function over 2 y.

作者: Terry Quinn.; .
来源: Ann Intern Med. 2025年178卷11期JC123页

GIM/FP/GP: [Formula: see text] Geriatrics: [Formula: see text] Public Health: [Formula: see text].

13. In adults with obesity but without type 2 diabetes, tirzepatide increased weight loss at 72 wk compared with semaglutide.

作者: Lenard I Lesser.; .
来源: Ann Intern Med. 2025年178卷11期JC122页

GIM/FP/GP: [Formula: see text] Endocrinology: [Formula: see text].

14. The Mediterranean Diet for Irritable Bowel Syndrome : A Randomized Clinical Trial.

作者: Joy O Bamidele.;Grace M Brownlow.;Rosie M Flack.;Rachel L Buckle.;Christian C Shaw.;Mohamed G Shiha.;Imran Aziz.
来源: Ann Intern Med. 2025年178卷12期1709-1717页

Patients with irritable bowel syndrome (IBS) frequently seek dietary advice, but few evidence-based options exist. Major societal guidelines recommend traditional dietary advice (TDA) as first-line therapy, with the cumbersome and resource-intensive low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) diet reserved as second-line therapy. Recent pilot data suggest that the Mediterranean diet (MD), renowned for its general health benefits, improves IBS symptoms, but whether it can be considered another first-line dietary option is unknown.

15. In early T2D inadequately controlled with diet and exercise, once-daily orforglipron reduced HbA1c vs. placebo at 40 wk.

作者: Maham Shahid.;Gunjan Y Gandhi.; .
来源: Ann Intern Med. 2025年178卷10期JC114页

GIM/FP/GP: [Formula: see text] Endocrinology: [Formula: see text].

16. In insulin-naive T2D, fixed-dose weekly efsitora was noninferior to daily glargine for reducing HbA1c at 52 wk.

作者: Michael Tanner.; .
来源: Ann Intern Med. 2025年178卷10期JC113页

GIM/FP/GP: [Formula: see text] Endocrinology: [Formula: see text].

17. In primary CDI, fecal microbiota transplantation was noninferior to vancomycin for clinical cure at 14 d without recurrence at 60 d.

作者: Henry S Sacks.; .
来源: Ann Intern Med. 2025年178卷10期JC117页

GIM/FP/GP: [Formula: see text] Gastroenterology: [Formula: see text] Infectious Disease: [Formula: see text].

18. In T2D and hypertension, the lower-sodium DASH4D diet reduced SBP more than a higher-sodium comparison diet at 5 wk.

作者: Darren Lau.;Raj Padwal.; .
来源: Ann Intern Med. 2025年178卷10期JC115页

GIM/FP/GP: [Formula: see text] Endocrinology: [Formula: see text].

19. Palliative Care Educational App for Family Caregivers of Homebound Patients With Incurable Cancer : A Single-Center Randomized Trial.

作者: Ying Yu.;Hao Xue.;Chen Suo.;Hui Wang.;Yanyu Pang.;Chunhui Ji.;Wanwan Hou.;Yuting Lu.;Dantong Lu.;Leqing Sang.;Jia Xu.;Chenbiao Li.;Li Jin.;Leming Shi.;Jiayun Zhang.;Ji Liang.;Weiwei Zhao.;Xingdong Chen.
来源: Ann Intern Med. 2025年178卷12期1737-1751页

Home-based palliative care relies on empowered family caregivers to overcome the limited availability of palliative care professional resources in managing incurable cancer.

20. Effect of Personalized Risk Messages on Uptake of Colorectal Cancer Screening : A Randomized Controlled Trial.

作者: Peter H Schwartz.;Susan M Perkins.;Susan M Rawl.;Karen K Schmidt.;Sandra Althouse.;Thomas F Imperiale.
来源: Ann Intern Med. 2025年178卷10期1390-1399页

Providing personalized risk information to patients and their providers could improve colorectal cancer (CRC) screening.

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1. In postmenopausal women at high risk for fracture, romosozumab for 3 mo was noninferior to 12 mo for increasing total hip BMD at 1 y.

2. In adults with ADHD, atomoxetine, methylphenidate, and CBT reduce symptom severity and the drugs are less tolerable vs. control at 12 wk.

3. The Effect of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID : An Adaptive Randomized Trial.

4. Timing of Pegfilgrastim Administration and Pegfilgrastim-Induced Bone Pain : A Prospective, Randomized, Phase 3 Trial.

5. Neither Metformin nor Ursodeoxycholic Acid Effectively Treats Postacute Sequelae of COVID-19 : A Randomized Clinical Trial.

6. Stable Supportive Footwear for Self-managing Hip Osteoarthritis Pain : A Randomized Clinical Trial.

7. Effect of Social Vulnerability on Efficacy of Bariatric Surgery Versus Medical and Lifestyle Intervention for Type 2 Diabetes: Analysis of the ARMMS-T2D Consortium of Randomized Trials.

8. Once-Weekly Oral Islatravir Plus Lenacapavir Versus Daily Oral Bictegravir, Emtricitabine, and Tenofovir Alafenamide in Persons With HIV-1 : A Phase 2 Randomized Study.

9. Integrating Methadone Services Into Primary Care in Ukraine: Two-Year Outcomes From a Randomized Trial.

10. In older adults living in rural China, a primary care-based fall prevention program vs. usual care reduced self-reported falls at 1 y.

11. Interventions to Improve Advance Care Planning Documentation in the Electronic Health Record : A Cluster Randomized Trial.

12. In older adults at risk for dementia, a structured vs. self-guided lifestyle intervention improved cognitive function over 2 y.

13. In adults with obesity but without type 2 diabetes, tirzepatide increased weight loss at 72 wk compared with semaglutide.

14. The Mediterranean Diet for Irritable Bowel Syndrome : A Randomized Clinical Trial.

15. In early T2D inadequately controlled with diet and exercise, once-daily orforglipron reduced HbA1c vs. placebo at 40 wk.

16. In insulin-naive T2D, fixed-dose weekly efsitora was noninferior to daily glargine for reducing HbA1c at 52 wk.

17. In primary CDI, fecal microbiota transplantation was noninferior to vancomycin for clinical cure at 14 d without recurrence at 60 d.

18. In T2D and hypertension, the lower-sodium DASH4D diet reduced SBP more than a higher-sodium comparison diet at 5 wk.

19. Palliative Care Educational App for Family Caregivers of Homebound Patients With Incurable Cancer : A Single-Center Randomized Trial.

20. Effect of Personalized Risk Messages on Uptake of Colorectal Cancer Screening : A Randomized Controlled Trial.