1819. Ebola Outbreak Response in the DRC with rVSV-ZEBOV-GP Ring Vaccination.
作者: Jean-Jacques Muyembe.;Hongchao Pan.;Richard Peto.;Abdourahamane Diallo.;Alhassane Touré.;Placide Mbala-Kingebene.;Stéphane H Bateyi Mustafa.;Ndjoloko Tambwe.;Sabue Mulangu.;Steve Ahuka-Mundeke.;Elisabeth Mukamba Musenga.;Godwin Enwere.;Pierre-Stéphane Gsell.;Ira M Longini.;Ximena Riveros Balta.;Chrissy H Roberts.;Michael Marks.;Michel N K Yao.;Abdou Salam Gueye.;Ibrahima-Soce Fall.;Peter Salama.;Michael J Ryan.;Ana Maria Henao-Restrepo.; .
来源: N Engl J Med. 2024年391卷24期2327-2336页
At the beginning of the 2018-2020 outbreak of Ebola virus disease (EVD) in eastern Democratic Republic of Congo (DRC), no vaccine had been licensed. However, cluster-randomized evidence from Guinea in 2015 had indicated that ring vaccination around new cases (targeting contacts and contacts-of-contacts) with the use of single-dose live-replicating rVSV-ZEBOV-GP vaccine reduced EVD rates starting 10 days after vaccination. Thus, ring vaccination was added to the standard control measures for that outbreak.
1820. Levofloxacin Preventive Treatment in Children Exposed to MDR Tuberculosis.
作者: Anneke C Hesseling.;Susan E Purchase.;Neil A Martinson.;Lee Fairlie.;H Simon Schaaf.;Joanna Brigden.;Suzanne Staples.;Diana M Gibb.;Anthony Garcia-Prats.;Francesca Conradie.;Charlotte McGowan.;Charlotte Layton.;Elize Batist.;Anne-Marie Demers.;Samukelisiwe Nyamathe.;Lisa Frigati.;Rebecca Turner.;Trinh Duong.;James A Seddon.
来源: N Engl J Med. 2024年391卷24期2315-2326页
Worldwide, approximately 2 million children younger than 15 years of age are infected with multidrug-resistant (MDR) Mycobacterium tuberculosis, with MDR tuberculosis developing in approximately 30,000 annually. Evidence from randomized, controlled trials on tuberculosis preventive treatment in persons exposed to MDR tuberculosis is lacking.
|