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1721. In RA, new use of JAK inhibitors was associated with nonmelanoma skin cancer vs. TNF inhibitors at 2 y.
Huss V, Bower H, Hellgren K, et al; ARTIS group. Cancer risks with JAKi and biological disease-modifying antirheumatic drugs in patients with rheumatoid arthritis or psoriatic arthritis: a national real-world cohort study. Ann Rheum Dis. 2023;82:911-919. 36868796.
1722. In adults at CV risk, Mediterranean-style or low-fat dietary programs vs. minimal interventions reduce all-cause mortality.
Karam G, Agarwal A, Sadeghirad B, et al. Comparison of seven popular structured dietary programmes and risk of mortality and major cardiovascular events in patients at increased cardiovascular risk: systematic review and network meta-analysis. BMJ. 2023;380:e072003. 36990505.
1723. Demonstration Project of Long-Acting Antiretroviral Therapy in a Diverse Population of People With HIV.
作者: Monica Gandhi.;Matthew Hickey.;Elizabeth Imbert.;Janet Grochowski.;Francis Mayorga-Munoz.;John D Szumowski.;Jon Oskarsson.;Mary Shiels.;John Sauceda.;Jorge Salazar.;Samantha Dilworth.;Janet Q Nguyen.;David V Glidden.;Diane V Havlir.;Katerina A Christopoulos.
来源: Ann Intern Med. 2023年176卷7期969-974页
Intramuscular cabotegravir (CAB) and rilpivirine (RPV) is the only long-acting antiretroviral therapy (LA-ART) regimen approved for people with HIV (PWH). Long-acting ART holds promise for improving outcomes among populations with barriers to adherence but is only approved for PWH who have virologic suppression with use of oral ART before initiating injectables.
1724. In statin-intolerant adults with, or at risk for, CV disease, bempedoic acid reduced MACE at a median 41 mo.
Nissen SE, Lincoff MA, Brennan D, et al; CLEAR Outcomes Investigators. Bempedoic acid and cardiovascular outcomes in statin-intolerant patients. N Engl J Med. 2023;388:1353-1364. 36876740.
1726. In type 1 diabetes, weekly basal insulin Fc was noninferior to daily insulin degludec for HbA1c at 26 wk.
Kazda CM, Bue-Valleskey JM, Chien J, et al. Novel once-weekly basal insulin Fc achieved similar glycemic control with a safety profile comparable to insulin degludec in patients with type 1 diabetes. Diabetes Care. 2023;46:1052-1059. 36920867.
1727. In ischemic stroke, adding EVT to usual care at 6 to 24 h improved functional status at 90 d.
Olthuis SGH, Pirson FAV, Pinckaers FME, et al; MR CLEAN-LATE investigators. Endovascular treatment versus no endovascular treatment after 6-24 h in patients with ischaemic stroke and collateral flow on CT angiography (MR CLEAN-LATE) in the Netherlands: a multicentre, open-label, blinded-endpoint, randomised, controlled, phase 3 trial. Lancet. 2023;401:1371-1380. 37003289.
1728. In CAD, treat-to-target statins were noninferior to high-intensity statins for a composite clinical outcome.
Hong SJ, Lee YJ, Lee SJ, et al; LODESTAR Investigators. Treat-to-target or high-intensity statin in patients with coronary artery disease: a randomized clinical trial. JAMA. 2023;329:1078-1087. 36877807.
1729. Effects of U.S. State Medical Cannabis Laws on Treatment of Chronic Noncancer Pain.
作者: Emma E McGinty.;Kayla N Tormohlen.;Nicholas J Seewald.;Mark C Bicket.;Alexander D McCourt.;Lainie Rutkow.;Sarah A White.;Elizabeth A Stuart.
来源: Ann Intern Med. 2023年176卷7期904-912页
State medical cannabis laws may lead patients with chronic noncancer pain to substitute cannabis in place of prescription opioid or clinical guideline-concordant nonopioid prescription pain medications or procedures.
1730. Performance of Rapid Antigen Tests to Detect Symptomatic and Asymptomatic SARS-CoV-2 Infection : A Prospective Cohort Study.
作者: Apurv Soni.;Carly Herbert.;Honghuang Lin.;Yi Yan.;Caitlin Pretz.;Pamela Stamegna.;Biqi Wang.;Taylor Orwig.;Colton Wright.;Seanan Tarrant.;Stephanie Behar.;Thejas Suvarna.;Summer Schrader.;Emma Harman.;Chris Nowak.;Vik Kheterpal.;Lokinendi V Rao.;Lisa Cashman.;Elizabeth Orvek.;Didem Ayturk.;Laura Gibson.;Adrian Zai.;Steven Wong.;Peter Lazar.;Ziyue Wang.;Andreas Filippaios.;Bruce Barton.;Chad J Achenbach.;Robert L Murphy.;Matthew L Robinson.;Yukari C Manabe.;Shishir Pandey.;Andres Colubri.;Laurel O'Connor.;Stephenie C Lemon.;Nisha Fahey.;Katherine L Luzuriaga.;Nathaniel Hafer.;Kristian Roth.;Toby Lowe.;Timothy Stenzel.;William Heetderks.;John Broach.;David D McManus.
来源: Ann Intern Med. 2023年176卷7期975-982页
The performance of rapid antigen tests (Ag-RDTs) for screening asymptomatic and symptomatic persons for SARS-CoV-2 is not well established.
1732. Time-Restricted Eating Without Calorie Counting for Weight Loss in a Racially Diverse Population : A Randomized Controlled Trial.
作者: Shuhao Lin.;Sofia Cienfuegos.;Mark Ezpeleta.;Kelsey Gabel.;Vasiliki Pavlou.;Andrea Mulas.;Kaitie Chakos.;Mara McStay.;Jackie Wu.;Lisa Tussing-Humphreys.;Shaina J Alexandria.;Julienne Sanchez.;Terry Unterman.;Krista A Varady.
来源: Ann Intern Med. 2023年176卷7期885-895页
Time-restricted eating (TRE), without calorie counting, has become a popular weight loss strategy, yet long-term randomized trials evaluating its efficacy are limited.
1737. Indefinite Anticoagulant Therapy for First Unprovoked Venous Thromboembolism : A Cost-Effectiveness Study.
作者: Faizan Khan.;Doug Coyle.;Kednapa Thavorn.;Sasha van Katwyk.;Tobias Tritschler.;Brian Hutton.;Grégoire Le Gal.;Marc A Rodger.;Dean A Fergusson.
来源: Ann Intern Med. 2023年176卷7期949-960页
Clinical practice guidelines recommend indefinite anticoagulation for a first unprovoked venous thromboembolism (VTE).
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