1262. Assessing the efficacy and tolerability of PET-guided BrECADD versus eBEACOPP in advanced-stage, classical Hodgkin lymphoma (HD21): a randomised, multicentre, parallel, open-label, phase 3 trial.
作者: Peter Borchmann.;Justin Ferdinandus.;Gundolf Schneider.;Alden Moccia.;Richard Greil.;Mark Hertzberg.;Valdete Schaub.;Andreas Hüttmann.;Felix Keil.;Judith Dierlamm.;Mathias Hänel.;Urban Novak.;Julia Meissner.;Andreas Zimmermann.;Stephan Mathas.;Josée M Zijlstra.;Alexander Fosså.;Andreas Viardot.;Bernd Hertenstein.;Sonja Martin.;Pratyush Giri.;Sebastian Scholl.;Max S Topp.;Wolfram Jung.;Vladan Vucinic.;Hans-Joachim Beck.;Andrea Kerkhoff.;Benjamin Unger.;Andreas Rank.;Roland Schroers.;Christian Meyer Zum Büschenfelde.;Maike de Wit.;Karolin Trautmann-Grill.;Peter Kamper.;Daniel Molin.;Stefanie Kreissl.;Helen Kaul.;Bastian von Tresckow.;Sven Borchmann.;Karolin Behringer.;Michael Fuchs.;Andreas Rosenwald.;Wolfram Klapper.;Hans-Theodor Eich.;Christian Baues.;Athanasios Zomas.;Michael Hallek.;Markus Dietlein.;Carsten Kobe.;Volker Diehl.; .; .; .; .; .
来源: Lancet. 2024年404卷10450期341-352页
Intensified systemic chemotherapy has the highest primary cure rate for advanced-stage, classical Hodgkin lymphoma but this comes with a cost of severe and potentially life long, persisting toxicities. With the new regimen of brentuximab vedotin, etoposide, cyclophosphamide, doxorubicin, dacarbazine, and dexamethasone (BrECADD), we aimed to improve the risk-to-benefit ratio of treatment of advanced-stage, classical Hodgkin lymphoma guided by PET after two cycles.
1263. Non-communicable diseases: can implementation research change the game for policy and practice?
作者: Kumanan Rasanathan.;Phyllis Dako-Gyeke.;Wanrudee Isaranuwatchai.;Yodi Mahendradhata.;Morven Roberts.;Giulia Loffreda.;Sarah Rylance.;Bente Mikkelsen.
来源: Lancet. 2024年404卷10466期1908-1910页 1264. Behavioural and sleep issues after initiation of elexacaftor-tezacaftor-ivacaftor in preschool-age children with cystic fibrosis.
作者: I Sermet-Gaudelus.;Sihem Benaboud.;Stéphanie Bui.;Tiphaine Bihouée.;Sophie Gautier.; .
来源: Lancet. 2024年404卷10448期117-120页 1266. Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk with and without diabetes or previous stroke: an open-label, blinded-outcome, randomised trial.
作者: Jiamin Liu.;Yan Li.;Jinzhuo Ge.;Xiaofang Yan.;Haibo Zhang.;Xin Zheng.;Jiapeng Lu.;Xi Li.;Yan Gao.;Lubi Lei.;Jing Liu.;Jing Li.; .
来源: Lancet. 2024年404卷10449期245-255页
Uncertainty exists about whether lowering systolic blood pressure to less than 120 mm Hg is superior to that of less than 140 mm Hg, particularly in patients with diabetes and patients with previous stroke.
1271. Multi-system involvement-including purpura fulminans-as an adverse effects of immune checkpoint inhibitor therapy for clear cell renal cell carcinoma.
作者: Chloé Wirbel.;Anne Laure Breton.;Léa Donzier.;Sophie Tartas.;Pierre Curings.;Caroline Pariset.;Emilie Berthoux.
来源: Lancet. 2024年403卷10446期2818-2819页 |