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101. A Contemporary Approach to Diagnosis and Treatment of Right Heart Thrombus Associated With Pulmonary Embolism.
作者: Yuri Matusov.;Suhail Dohad.;Dominick Megna.;Mona Ranade.;Maidah Yaqoob.;Janine R E Vintch.
来源: Chest. 2026年
Right heart thrombus (RHT) in the setting of pulmonary embolism (PE) is a uniquely high-risk event. RHT management has not been rigorously studied in clinical trials and is not part of risk stratification schemas for PE. However, it is a major risk factor for clinical deterioration and mortality. There are no guidelines for RHT management, and most practice is based on case series and anecdote. Historically, RHT has been managed with surgical embolectomy or systemic thrombolysis; however, there is now increasing experience with catheter-based mechanical thrombectomy. Furthermore, a subset of patients with RHT can be treated with anticoagulation monotherapy. In this article, the authors use existing evidence for diagnostic tools and outcomes data to provide a practical framework for approaching RHT in the setting of PE.
102. Initial Combination of Macitentan With Riociguat in the Treatment of Pulmonary Arterial Hypertension.
作者: Michele D'Alto.;Silvia Papa.;Laura Scelsi.;Rosalinda Madonna.;Francesca Renon.;Giuseppe Paciocco.;Michele Correale.;Gavino Casu.;Edoardo Bonsante.;Stefano Ghio.;Emanuele Romeo.;Roberto Badagliacca.;Robert Naeije.
来源: Chest. 2026年 103. Prognostic Significance of Mild Exacerbations or 1 Moderate Exacerbation in COPD: A Prospective Community-Based Cohort Study.
作者: Fan Wu.;Qi Wan.;Heshen Tian.;Youlan Zheng.;Ningning Zhao.;Zhishan Deng.;Kunning Zhou.;Gaoying Tang.;Lifei Lu.;Cuiqiong Dai.;Xiaohui Wu.;Suyin Huang.;Junfeng Lin.;Fangyan Wu.;Guannan Cai.;Xianliang Zeng.;Jincong Gan.;Huixian Lin.;Erkang Yi.;Zhifeng Gao.;Changli Yang.;Shengtang Chen.;Yongqing Huang.;Shuqing Yu.;Yumin Zhou.;Pixin Ran.; .
来源: Chest. 2026年
The association between frequent COPD exacerbations and poor respiratory health outcomes is well established, but the associations of only mild exacerbations and only 1 moderate exacerbation with prognosis remain controversial, especially among community participants with COPD.
104. Patient Perceptions of Quality of Shared Decision-Making for Lung Cancer Screening in Telehealth vs In-Person Discussions.
作者: Stephanie A Robinson.;Sara Shusterman.;Anna M Barker.;Gemmae M Fix.;Renda Soylemez Wiener.
来源: Chest. 2026年
Guidelines recommend shared decision-making (SDM) about lung cancer screening (LCS) to ensure that choices about LCS are informed and consistent with patient goals. Telehealth may increase access to SDM, but its quality compared with in-person delivery remains unclear.
105. Dupilumab Reduces Mucus Radiodensity and New Plug Formation in Asthma.
作者: Ekamdeep Sandhu.;Nandhitha Ragunayakam.;Anusha A Mappanasingam.;Yonni Friedlander.;Carmen Venegas Garrido.;Melanie Kjarsgaard.;Ashutosh Thakar.;Nisarg Radadia.;Manali Mukherjee.;Parameswaran Nair.;Sarah Svenningsen.
来源: Chest. 2026年
Dupilumab, an IL-4 and IL-13 antagonist, reduces the burden of mucus plugs visualized by CT imaging in asthma.
106. Impact of Antifibrotic Adherence and Dosing on Risk of Mortality and Hospitalization in Idiopathic Pulmonary Fibrosis: A Nested Case-Control Study.
作者: Huiping Xu.;Erin Meier.;Mamta S Chhabria.;Alison M DeDent.;Siu L Hui.;Zuoyi Zhang.;Ryan D Boente.
来源: Chest. 2026年
Antifibrotics, including nintedanib and pirfenidone, are effective in slowing the decline of lung function for patients with idiopathic pulmonary fibrosis (IPF). However, their adoption rates are remarkably low, and substantial proportions of patients undergo dose reduction or treatment discontinuation because of the high incidence of adverse events.
107. Meconium Aspiration Syndrome and the Association With Preschool Asthma.
Meconium aspiration syndrome (MAS) is an acute neonatal respiratory disorder resulting from aspiration of meconium-stained amniotic fluid, leading to airway obstruction, inflammation, and hypoxemia. Although its perinatal presentation is well described, its long-term association with asthma remains unknown.
108. Effects of Antifungal Treatment in COVID-19-Associated Pulmonary Aspergillosis: A European Multicenter Cohort Study.
作者: Florian Reizine.;Simon Feys.;Danila Seidel.;Matteo Mauget.;Stefan Hatzl.;Arnaud Gacouin.;Yoann Launey.;Jannes Heylen.;Jean-Marc Tadié.;Pierre Fillâtre.;Matthias Verbesselt.;Philipp Koehler.;Marie-Elisabeth Bougnoux.;Eric Dannaoui.;Jean-Ralph Zahar.;Hélène Guegan.;Florence Robert-Gangneux.; .;Joost Wauters.;Oliver A Cornely.;Martin Hoenigl.;Jean-Pierre Gangneux.
来源: Chest. 2026年
The management of COVID-19-associated invasive aspergillosis (CAPA) is still debated while cases continue to occur, and more and more frequently in vulnerable populations, stressing the importance of obtaining data on the treatment of this disease. Only small cohort studies and case reports have yet discussed this essential issue, and the data obtained are insufficient to make conclusions with confidence.
117. A 2-Month-Old Boy With Respiratory Distress, Thrombocytopenia, and an Aggressive Mediastinal Mass.
A 2-month-old male infant with symptoms of dyspnea and progressive thrombocytopenia was referred to our tertiary care center. Physical examination at the referring hospital revealed tachypnea, head-nodding respiration, and poor appetite. Laboratory tests revealed severe thrombocytopenia (platelet count, 11 × 109/L), anemia (hemoglobin, 73 g/L), and coagulopathy (thrombin time, 33.9 s; fibrinogen: 0.25 g/L; D-dimer: 55.13 mg/L). Echocardiography revealed pericardial effusion and decreased ventricular function. He was initially diagnosed at the referring hospital with "severe pneumonia and thrombocytopenia" and received empirical treatment with antibiotics and platelet and red cell transfusions but showed limited clinical improvement.
118. A 71-Year-Old Woman With Dyspnea and Hypoxemia After Liver Metastases Cryoablation.
作者: Jose M Martinez Manzano.;Ravi V Gottumukkala.;Miguel J Divo.;Anuradha Ramaswamy.
来源: Chest. 2026年169卷4期e129-e134页
A 71-year-old woman with a medical history of metastatic non-small cell lung cancer treated with left-side pneumonectomy 10 years ago, stereotactic body radiation therapy of a single right lung metastasis 7 years ago, and targeted therapy with sotorasib for the last 6 years (+KRAS G12C tumor), obesity (BMI of 33), and OSA on nocturnal CPAP, presents to the pulmonary office with dyspnea.
119. A 71-Year-Old Man With Neck Pain, Ptosis, and Complex Cystic Superior Mediastinal Lesion.
作者: Khadija Sulaiman Al Adawi.;Tiffany Ni.;Negar Ahmadi.;Nicole L K Pun.;Binita Riya Chacko.
来源: Chest. 2026年169卷4期e123-e127页
A 71-year-old man sought treatment at the emergency department with a 3-week history of posterior neck pain, generalized weakness, and new-onset right-sided ptosis. He described the neck pain as sharp (6 out of 10) and nonradiating, with a sensation of neck "dropping" that required intermittent manual repositioning and support with a neck brace. Pertinent positive findings included increased fatigue, dizziness, loss of balance, and excessive sleep. Pertinent negative findings included recent trauma, travel, sick contacts, chest pain, shortness of breath, nausea, vomiting, abdominal pain, altered bowel or urinary habits, headache, and fever. His past medical history included dyslipidemia, nephrolithiasis, and benign prostatic hyperplasia. He reported that he does not smoke or consume alcohol and has no occupational exposure risks.
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