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101. National Retrospective Cohort Study Assessing Association of Hospital Transfer-In Prevalence With Hospital Outcomes.
作者: Nathan Mesfin.;Nicholas E Ingraham.;Benjamin Langworthy.;R Adams Dudley.;Kathryn M Pendleton.
来源: Chest. 2026年
Transferred patients are clinically complex, with high mortality risk and longer length of stay. Although interhospital transfers are common, it is unclear if hospitals with higher rates of transfer-in patients have worse risk-adjusted performance metrics because of their patient case mix.
102. Menopause Is Associated With Lower Lung Function in Women With and Without HIV.
作者: Rebecca A Abelman.;Fan Xia.;M Bradley Drummond.;Mirjam-Colette Kempf.;Maria L Alcaide.;Lauren F Collins.;Amanda Blair Spence.;Brandilyn A Peters.;Deborah Gustafson.;Ken M Kunisaki.;Richard J Wang.;Phyllis C Tien.;Laurence Huang.
来源: Chest. 2026年
Menopause accelerates lung function decline in women without HIV, but whether menopause modifies lung function in women with HIV (WWH) is unknown.
103. Phylogenomic and Clinical Perspectives of an East Asia-Specific Cluster of Mycobacterium massiliense.
作者: Dong Hyun Kim.;Seonghye Jung.;Sangkwon Jung.;Joong-Yub Kim.;Jake Whang.;Yong Jin Gil.;Jae-Joon Yim.;Nakwon Kwak.;Bum-Joon Kim.
来源: Chest. 2026年
Mycobacterium abscessus subspecies massiliense (MAM) can form genetically related clusters through continuous within-host adaptations.
104. A Contemporary Approach to Diagnosis and Treatment of Right Heart Thrombus Associated With Pulmonary Embolism.
作者: Yuri Matusov.;Suhail Dohad.;Dominick Megna.;Mona Ranade.;Maidah Yaqoob.;Janine R E Vintch.
来源: Chest. 2026年
Right heart thrombus (RHT) in the setting of pulmonary embolism (PE) is a uniquely high-risk event. RHT management has not been rigorously studied in clinical trials and is not part of risk stratification schemas for PE. However, it is a major risk factor for clinical deterioration and mortality. There are no guidelines for RHT management, and most practice is based on case series and anecdote. Historically, RHT has been managed with surgical embolectomy or systemic thrombolysis; however, there is now increasing experience with catheter-based mechanical thrombectomy. Furthermore, a subset of patients with RHT can be treated with anticoagulation monotherapy. In this article, the authors use existing evidence for diagnostic tools and outcomes data to provide a practical framework for approaching RHT in the setting of PE.
105. Initial Combination of Macitentan With Riociguat in the Treatment of Pulmonary Arterial Hypertension.
作者: Michele D'Alto.;Silvia Papa.;Laura Scelsi.;Rosalinda Madonna.;Francesca Renon.;Giuseppe Paciocco.;Michele Correale.;Gavino Casu.;Edoardo Bonsante.;Stefano Ghio.;Emanuele Romeo.;Roberto Badagliacca.;Robert Naeije.
来源: Chest. 2026年 106. Prognostic Significance of Mild Exacerbations or 1 Moderate Exacerbation in COPD: A Prospective Community-Based Cohort Study.
作者: Fan Wu.;Qi Wan.;Heshen Tian.;Youlan Zheng.;Ningning Zhao.;Zhishan Deng.;Kunning Zhou.;Gaoying Tang.;Lifei Lu.;Cuiqiong Dai.;Xiaohui Wu.;Suyin Huang.;Junfeng Lin.;Fangyan Wu.;Guannan Cai.;Xianliang Zeng.;Jincong Gan.;Huixian Lin.;Erkang Yi.;Zhifeng Gao.;Changli Yang.;Shengtang Chen.;Yongqing Huang.;Shuqing Yu.;Yumin Zhou.;Pixin Ran.; .
来源: Chest. 2026年
The association between frequent COPD exacerbations and poor respiratory health outcomes is well established, but the associations of only mild exacerbations and only 1 moderate exacerbation with prognosis remain controversial, especially among community participants with COPD.
107. Patient Perceptions of Quality of Shared Decision-Making for Lung Cancer Screening in Telehealth vs In-Person Discussions.
作者: Stephanie A Robinson.;Sara Shusterman.;Anna M Barker.;Gemmae M Fix.;Renda Soylemez Wiener.
来源: Chest. 2026年
Guidelines recommend shared decision-making (SDM) about lung cancer screening (LCS) to ensure that choices about LCS are informed and consistent with patient goals. Telehealth may increase access to SDM, but its quality compared with in-person delivery remains unclear.
108. Dupilumab Reduces Mucus Radiodensity and New Plug Formation in Asthma.
作者: Ekamdeep Sandhu.;Nandhitha Ragunayakam.;Anusha A Mappanasingam.;Yonni Friedlander.;Carmen Venegas Garrido.;Melanie Kjarsgaard.;Ashutosh Thakar.;Nisarg Radadia.;Manali Mukherjee.;Parameswaran Nair.;Sarah Svenningsen.
来源: Chest. 2026年
Dupilumab, an IL-4 and IL-13 antagonist, reduces the burden of mucus plugs visualized by CT imaging in asthma.
109. Impact of Antifibrotic Adherence and Dosing on Risk of Mortality and Hospitalization in Idiopathic Pulmonary Fibrosis: A Nested Case-Control Study.
作者: Huiping Xu.;Erin Meier.;Mamta S Chhabria.;Alison M DeDent.;Siu L Hui.;Zuoyi Zhang.;Ryan D Boente.
来源: Chest. 2026年
Antifibrotics, including nintedanib and pirfenidone, are effective in slowing the decline of lung function for patients with idiopathic pulmonary fibrosis (IPF). However, their adoption rates are remarkably low, and substantial proportions of patients undergo dose reduction or treatment discontinuation because of the high incidence of adverse events.
110. Meconium Aspiration Syndrome and the Association With Preschool Asthma.
Meconium aspiration syndrome (MAS) is an acute neonatal respiratory disorder resulting from aspiration of meconium-stained amniotic fluid, leading to airway obstruction, inflammation, and hypoxemia. Although its perinatal presentation is well described, its long-term association with asthma remains unknown.
111. Effects of Antifungal Treatment in COVID-19-Associated Pulmonary Aspergillosis: A European Multicenter Cohort Study.
作者: Florian Reizine.;Simon Feys.;Danila Seidel.;Matteo Mauget.;Stefan Hatzl.;Arnaud Gacouin.;Yoann Launey.;Jannes Heylen.;Jean-Marc Tadié.;Pierre Fillâtre.;Matthias Verbesselt.;Philipp Koehler.;Marie-Elisabeth Bougnoux.;Eric Dannaoui.;Jean-Ralph Zahar.;Hélène Guegan.;Florence Robert-Gangneux.; .;Joost Wauters.;Oliver A Cornely.;Martin Hoenigl.;Jean-Pierre Gangneux.
来源: Chest. 2026年
The management of COVID-19-associated invasive aspergillosis (CAPA) is still debated while cases continue to occur, and more and more frequently in vulnerable populations, stressing the importance of obtaining data on the treatment of this disease. Only small cohort studies and case reports have yet discussed this essential issue, and the data obtained are insufficient to make conclusions with confidence.
120. A 2-Month-Old Boy With Respiratory Distress, Thrombocytopenia, and an Aggressive Mediastinal Mass.
A 2-month-old male infant with symptoms of dyspnea and progressive thrombocytopenia was referred to our tertiary care center. Physical examination at the referring hospital revealed tachypnea, head-nodding respiration, and poor appetite. Laboratory tests revealed severe thrombocytopenia (platelet count, 11 × 109/L), anemia (hemoglobin, 73 g/L), and coagulopathy (thrombin time, 33.9 s; fibrinogen: 0.25 g/L; D-dimer: 55.13 mg/L). Echocardiography revealed pericardial effusion and decreased ventricular function. He was initially diagnosed at the referring hospital with "severe pneumonia and thrombocytopenia" and received empirical treatment with antibiotics and platelet and red cell transfusions but showed limited clinical improvement.
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