1143. Causal attribution of human papillomavirus genotypes to invasive cervical cancer worldwide: a systematic analysis of the global literature.
作者: Feixue Wei.;Damien Georges.;Irene Man.;Iacopo Baussano.;Gary M Clifford.
来源: Lancet. 2024年404卷10451期435-444页
Understanding the proportion of invasive cervical cancer (ICC) caused by different human papillomavirus (HPV) genotypes can inform primary (ie, vaccination) and secondary (ie, screening) prevention efforts that target specific HPV genotypes. However, using the global literature to estimate population attributable fractions (AFs) requires a methodological framework to address HPV genotype-specific causality from aggregated data. We aimed to estimate the proportion of ICC caused by different HPV genotypes at the global, regional, and national level.
1155. A manifesto on improving cancer care in conflict-impacted populations.
作者: Tedros Adhanom Ghebreyesus.;Dina Mired.;Richard Sullivan.;Alexandra Mueller.;Andreas Charalambous.;Arman Kacharian.;Christos Tsagkaris.;Enrique Soto-Perez-de-Celis.;Henrik Grigoryan.;Julie Gralow.;Andre Ilbawi.;Khaled Ghanem.;Layth Mula-Hussain.;Bente Mikkelsen.;Mulugeta Yimer.;Nazik Hammad.;Stella Arakelyan.;Tezer Kutluk.;Zeena Salman.;Mark Lawler.;Gevorg Tamamyan.;Maria V Babak.;Jemma Arakelyan.
来源: Lancet. 2024年404卷10451期427页 1160. Safety and efficacy of subcutaneous iscalimab (CFZ533) in two distinct populations of patients with Sjögren's disease (TWINSS): week 24 results of a randomised, double-blind, placebo-controlled, phase 2b dose-ranging study.
作者: Benjamin A Fisher.;Xavier Mariette.;Athena Papas.;Thomas Grader-Beck.;Hendrika Bootsma.;Wan-Fai Ng.;P L A van Daele.;Stephanie Finzel.;Ghaith Noaiseh.;Sergio Elgueta.;Josef Hermann.;Sara S McCoy.;Esen Akpek.;Arthur Bookman.;Monika Sopala.;Michela Montecchi-Palmer.;Wen-Lin Luo.;Cornelia Scheurer.;Wolfgang Hueber.; .
来源: Lancet. 2024年404卷10452期540-553页
Sjögren's disease is a chronic autoimmune disease with an unmet need for targeted therapies. The aim of the TWINSS study is to evaluate the safety and efficacy of iscalimab, a monoclonal antibody against CD40, in patients with active Sjögren's disease.
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