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1142. Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity.
作者: W Timothy Garvey.;Matthias Blüher.;Cynthia Karenina Osorto Contreras.;Melanie J Davies.;Eva Winning Lehmann.;Kirsi H Pietiläinen.;Domenica Rubino.;Paolo Sbraccia.;Thomas Wadden.;Niels Zeuthen.;John P H Wilding.; .
来源: N Engl J Med. 2025年393卷7期635-647页
Semaglutide at a dose of 2.4 mg has established weight-loss and cardiovascular benefits, and cagrilintide at a dose of 2.4 mg has shown promising results in early-phase trials; the efficacy of the combination (known as CagriSema) on weight loss in persons with either overweight and coexisting conditions or obesity is unknown.
1143. Cagrilintide-Semaglutide in Adults with Overweight or Obesity and Type 2 Diabetes.
作者: Melanie J Davies.;Harpreet S Bajaj.;Christa Broholm.;Astrid Eliasen.;W Timothy Garvey.;Carel W le Roux.;Ildiko Lingvay.;Christian Bøge Lyndgaard.;Julio Rosenstock.;Sue D Pedersen.; .
来源: N Engl J Med. 2025年393卷7期648-659页
Cagrilintide and semaglutide have each been shown to induce weight loss as monotherapies. Data are needed on the coadministration of cagrilintide and semaglutide (called CagriSema) for weight management in adults with type 2 diabetes, including those in a subgroup who are undergoing continuous glucose monitoring.
1145. Stem Cell-Derived, Fully Differentiated Islets for Type 1 Diabetes.
作者: Trevor W Reichman.;James F Markmann.;Jon Odorico.;Piotr Witkowski.;John J Fung.;Martin Wijkstrom.;Fouad Kandeel.;Eelco J P de Koning.;Anne L Peters.;Chantal Mathieu.;Leslie S Kean.;Bote G Bruinsma.;Chenkun Wang.;Molly Mascia.;Bastiano Sanna.;Gautham Marigowda.;Felicia Pagliuca.;Doug Melton.;Camillo Ricordi.;Michael R Rickels.; .
来源: N Engl J Med. 2025年393卷9期858-868页
Zimislecel is an allogeneic stem cell-derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed.
1146. Neoadjuvant and Adjuvant Pembrolizumab in Locally Advanced Head and Neck Cancer.
作者: Ravindra Uppaluri.;Robert I Haddad.;Yungan Tao.;Christophe Le Tourneau.;Nancy Y Lee.;William Westra.;Rebecca Chernock.;Makoto Tahara.;Kevin J Harrington.;Arkadiy L Klochikhin.;Irene Braña.;Gustavo Vasconcelos Alves.;Brett G M Hughes.;Marc Oliva.;Iane Pinto Figueiredo Lima.;Tsutomu Ueda.;Tomasz Rutkowski.;Ursula Schroeder.;Paul-Stefan Mauz.;Thorsten Fuereder.;Simon Laban.;Nobuhiko Oridate.;Aron Popovtzer.;Nicolas Mach.;Yevhen Korobko.;Diogo Alpuim Costa.;Anupama Hooda-Nehra.;Cristina P Rodriguez.;R Bryan Bell.;Cole Manschot.;Kimberly Benjamin.;Burak Gumuscu.;Douglas Adkins.; .
来源: N Engl J Med. 2025年393卷1期37-50页
The benefit of the addition of perioperative pembrolizumab to standard care with surgery and adjuvant therapy for patients with locally advanced head and neck squamous-cell carcinoma (HNSCC) is unclear.
1157. Three Cases of Vertical Transmission of Clade Ib Mpox Virus.
作者: Emmanuel Hasivirwe Vakaniaki.;Nono-Raymond Swar Kuispond.;Yuichiro Hirata.;Eugene Bangwen.;Isabel Brosius.;Eddy Kinganda-Lusamaki.;Seiya Ozono.;Harutaka Katano.;Laurent Gabanga Ndunge.;Noella Mulopo-Mukanya.;Jean-Claude Tshomba.;Elise De Vos.;Christophe Van Dijck.;Papy Munganga.;Guy Mukari.;Yves Mujula.;Divin Mazambi Mambo.;Steeven Bilembo Kitwanda.;Nadine Maliyamungu-Bubala.;Léandre Mutimbwa-Mambo.;Ian Crozier.;Lori E Dodd.;Olivier Tshiani-Mbaya.;Bienvenu Massamba Lebwaze.;Espoir Bwenge Malembaka.;Isaac Barhishindi.;Susanne Krasemann.;Robert Colebunders.;Patrick D M C Katoto.;Sheila Makiala-Mandanda.;Jason Kindrachuk.;Anne W Rimoin.;Jean-Jacques Muyembe-Tamfum.;Daniel Mukadi-Bamuleka.;Tony Wawina-Bokalanga.;Sabin Sabiti Nundu.;Tadaki Suzuki.;Raphaël Bulakali Chirimwami.;Laurens Liesenborghs.;Placide Mbala-Kingebeni.
来源: N Engl J Med. 2025年392卷23期2385-2387页 |