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764. Genetic sequencing analysis of monkeypox virus clade I in Republic of the Congo: a cross-sectional, descriptive study.
作者: Claude Kwe Yinda.;Félix Koukouikila-Koussounda.;Pembe Issamou Mayengue.;Reiche Golmard Elenga.;Benjamin Greene.;Missiani Ochwoto.;Ghislain Dzeret Indolo.;Yanne Vanessa Thiécesse Mavoungou.;Dachel Aymard Eyenet Boussam.;Bani Reize Vishnou Ampiri.;Chastel Claujens Mapanguy Mfoutou.;Yvanhe Deho Kianguebeni Mbouala.;Francine Ntoumi.;Jean-Médard Kankou.;Vincent J Munster.;Fabien Roch Niama.
来源: Lancet. 2024年404卷10465期1815-1822页
Monkeypox virus clade I is endemic in several central African countries and characterised by an increase in disease severity and mortality. Since October, 2023, a large-scale mpox outbreak has emerged in DR Congo, and in March, 2024, the first individuals with mpox were reported outside the endemic areas in Republic of the Congo. We aimed to provide insight into the epidemic by sequencing samples obtained from individuals with mpox in Republic of the Congo.
765. To keep health as a unifying force, we must put resources into tackling health misinformation and disinformation.
作者: Jessamy Bagenal.;Sian Crucefix.;Chloe Wilson.;Tim Dehnel.;Hugh Thomas.;Pierre Nauleau.;Claire Lenahan.;Ursula Hofer.
来源: Lancet. 2024年404卷10465期1792-1794页 766. Cadonilimab plus platinum-based chemotherapy with or without bevacizumab as first-line treatment for persistent, recurrent, or metastatic cervical cancer (COMPASSION-16): a randomised, double-blind, placebo-controlled phase 3 trial in China.
作者: Xiaohua Wu.;Yang Sun.;Hongying Yang.;Jing Wang.;Hanmei Lou.;Dan Li.;Ke Wang.;Hui Zhang.;Tao Wu.;Yuzhi Li.;Chunyan Wang.;Guiling Li.;Yifeng Wang.;Dapeng Li.;Ying Tang.;Mei Pan.;Hongyi Cai.;Weihu Wang.;Bing Yang.;Hua Qian.;Qiuhong Tian.;Desheng Yao.;Ying Cheng.;Bing Wei.;Xiumin Li.;Tao Wang.;Min Hao.;Xiaohong Wang.;Tiejun Wang.;Juntao Ran.;Hong Zhu.;Lijing Zhu.;Xianling Liu.;Yunxia Li.;Lihong Chen.;Qingshan Li.;Xiaojian Yan.;Fei Wang.;Hongbing Cai.;Yunyan Zhang.;Zhiqing Liang.;Funan Liu.;Yi Huang.;Bairong Xia.;Pengpeng Qu.;Genhai Zhu.;Youguo Chen.;Kun Song.;Meili Sun.;Zhengzheng Chen.;Qiang Zhou.;Lina Hu.;Guzhalinuer Abulizi.;Hongyan Guo.;Sihai Liao.;Yijing Ye.;Ping Yan.;Qiu Tang.;Guoping Sun.;Ting Liu.;Dongmei Lu.;Mingxiu Hu.;Zhongmin M Wang.;Baiyong Li.;Michelle Xia.
来源: Lancet. 2024年404卷10463期1668-1676页
Cadonilimab is a bispecific antibody targeting PD-1 and CTLA-4, which has shown substantial clinical benefits in advanced cervical cancer. In the COMPASSION-16 trial, we aimed to evaluate the addition of cadonilimab to first-line standard chemotherapy in persistent, recurrent, or metastatic cervical cancer.
772. Global health 2050: the path to halving premature death by mid-century.
作者: Dean T Jamison.;Lawrence H Summers.;Angela Y Chang.;Omar Karlsson.;Wenhui Mao.;Ole F Norheim.;Osondu Ogbuoji.;Marco Schäferhoff.;David Watkins.;Olusoji Adeyi.;George Alleyne.;Ala Alwan.;Shuchi Anand.;Ruth Belachew.;Seth F Berkley.;Stefano M Bertozzi.;Sarah Bolongaita.;Donald Bundy.;Flavia Bustreo.;Marcia C Castro.;Simiao Chen.;Victoria Y Fan.;Ayodamope Fawole.;Richard Feachem.;Lia Gebremedhin.;Jayati Ghosh.;Sue J Goldie.;Eduardo Gonzalez-Pier.;Yan Guo.;Sanjeev Gupta.;Prabhat Jha.;Felicia Marie Knaul.;Margaret E Kruk.;Christoph Kurowski.;Gordon G Liu.;Saeda Makimoto.;Awad Mataria.;Rachel Nugent.;Hitoshi Oshitani.;Ariel Pablos-Mendez.;Richard Peto.;Neelam Sekhri Feachem.;Srinath Reddy.;Nisreen Salti.;Helen Saxenian.;Justina Seyi-Olajide.;Agnes Soucat.;Stéphane Verguet.;Armand Zimmerman.;Gavin Yamey.
来源: Lancet. 2024年404卷10462期1561-1614页 773. Induction chemotherapy followed by standard chemoradiotherapy versus standard chemoradiotherapy alone in patients with locally advanced cervical cancer (GCIG INTERLACE): an international, multicentre, randomised phase 3 trial.
作者: Mary McCormack.;Gemma Eminowicz.;Dolores Gallardo.;Patricia Diez.;Laura Farrelly.;Christopher Kent.;Emma Hudson.;Miguel Panades.;Tony Mathew.;Anjana Anand.;Mojca Persic.;Jennifer Forrest.;Rajanee Bhana.;Nicholas Reed.;Anne Drake.;Madhavi Adusumalli.;Asima Mukhopadhyay.;Margaret King.;Karen Whitmarsh.;John McGrane.;Nicoletta Colombo.;Choi Mak.;Ranajit Mandal.;Rahul Roy Chowdhury.;Gabriela Alamilla-Garcia.;Adriana Chávez-Blanco.;Hilary Stobart.;Amanda Feeney.;Simran Vaja.;Anne-Marie Hacker.;Allan Hackshaw.;Jonathan Andrew Ledermann.; .
来源: Lancet. 2024年404卷10462期1525-1535页
Locally advanced cervical cancer is treated with chemoradiotherapy (standard of care), but many patients still relapse and die from metastatic disease. We investigated chemoradiotherapy with or without induction chemotherapy to determine whether induction chemotherapy improves both progression-free survival and overall survival.
774. Investing in the future of global health.
作者: Austen Davis.;Samira Asma.;Mark Blecher.;Christoph Benn.;Satoshi Ezoe.;Helga Fogstad.;Gargee Gosh.;Gabriel Leung.;Serena Ng.;Justice Nonvignon.;Olive Shisana.;Viroj Tangcharoensathien.;Juan Pablo Uribe.;John-Arne Røttingen.
来源: Lancet. 2024年404卷10462期1500-1503页 780. Efficacy of a culturally adapted, cognitive behavioural therapy-based intervention for postnatal depression in British south Asian women (ROSHNI-2): a multicentre, randomised controlled trial.
作者: Nusrat Husain.;Farah Lunat.;Karina Lovell.;Jahanara Miah.;Carolyn A Chew-Graham.;Penny Bee.;Ahmed Waqas.;Matthias Pierce.;Deepali Sharma.;Najia Atif.;Saadia Aseem.;Kamaldeep Bhui.;Peter Bower.;Traolach Brugha.;Nasim Chaudhry.;Akbar Ullah.;Linda Davies.;Nadeem Gire.;Joe Kai.;Jillian Morrison.;Naeem Mohmed.;Shanaya Rathod.;Najma Siddiqi.;Siham Sikander.;Waquas Waheed.;Ilyas Mirza.;Christopher Williams.;Nosheen Zaidi.;Richard Emsley.;Atif Rahman.;Richard Morriss.
来源: Lancet. 2024年404卷10461期1430-1443页
Postnatal depression necessitates timely and effective interventions to mitigate adverse maternal and child outcomes in the short term and over the life course. British south Asian women with depression are often underserved and undertreated due to stigma, language barriers, and cultural barriers. This trial aimed to test the clinical efficacy of a culturally adapted, group cognitive behavioural therapy (CBT)-based intervention, the Positive Health Programme (PHP), delivered by non-specialist health workers for postnatal depression in British south Asian women.
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