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501. Understanding the malignant potential of gastric metaplasia of the oesophagus and its relevance to Barrett's oesophagus surveillance: individual-level data analysis.
作者: Emily L Black.;Emma Ococks.;Ginny Devonshire.;Alvin Wei Tian Ng.;Maria O'Donovan.;Shalini Malhotra.;Monika Tripathi.;Ahmad Miremadi.;Adam Freeman.;Hannah Coles.; .;Rebecca C Fitzgerald.
来源: Gut. 2024年73卷5期729-740页
Whether gastric metaplasia (GM) of the oesophagus should be considered as Barrett's oesophagus (BO) is controversial. Given concern intestinal metaplasia (IM) may be missed due to sampling, the UK guidelines include GM as a type of BO. Here, we investigated whether the risk of misdiagnosis and the malignant potential of GM warrant its place in the UK surveillance.
514. Chimeric antigen receptors of HBV envelope proteins inhibit hepatitis B surface antigen secretion.
作者: Yang Wang.;Qiqi Li.;Cheng Li.;Cong Wang.;Shijie Wang.;Wenjie Yuan.;Demin Yu.;Ke Zhang.;Bisheng Shi.;Xiaomei Chen.;Tiantian Liu.;Zhenghong Yuan.;Shuping Tong.;Michael Nassal.;Yu-Mei Wen.;Yong-Xiang Wang.
来源: Gut. 2024年73卷4期668-681页
Chronic hepatitis B (CHB) caused by HBV infection greatly increases the risk of liver cirrhosis and hepatocellular carcinoma. Hepatitis B surface antigen (HBsAg) plays critical roles in the pathogenesis of CHB. HBsAg loss is the key indicator for cure of CHB, but is rarely achieved by current approved anti-HBV drugs. Therefore, novel anti-HBV strategies are urgently needed to achieve sustained HBsAg loss.
516. Spatial transcriptomics reveals a low extent of transcriptionally active hepatitis B virus integration in patients with HBsAg loss.
作者: Xiaoqi Yu.;Qiming Gong.;Demin Yu.;Yongyan Chen.;Ying Jing.;Fabien Zoulim.;Xinxin Zhang.
来源: Gut. 2024年73卷5期797-809页
Hepatitis B virus (HBV) can integrate into the chromosomes of infected hepatocytes, contributing to the production of hepatitis B surface antigen (HBsAg) and to hepatocarcinogenesis. In this study, we aimed to explore whether transcriptionally active HBV integration events spread throughout the liver tissue in different phases of chronic HBV infection, especially in patients with HBsAg loss.
517. Gut virome in inflammatory bowel disease and beyond.
作者: Hein Min Tun.;Ye Peng.;Luca Massimino.;Zhen Ye Sin.;Tommaso Lorenzo Parigi.;Amanda Facoetti.;Shaila Rahman.;Silvio Danese.;Federica Ungaro.
来源: Gut. 2024年73卷2期350-360页
The gut virome is a dense community of viruses inhabiting the gastrointestinal tract and an integral part of the microbiota. The virome coexists with the other components of the microbiota and with the host in a dynamic equilibrium, serving as a key contributor to the maintenance of intestinal homeostasis and functions. However, this equilibrium can be interrupted in certain pathological states, including inflammatory bowel disease, causing dysbiosis that may participate in disease pathogenesis. Nevertheless, whether virome dysbiosis is a causal or bystander event requires further clarification.
518. Novel insights into causal effects of serum lipids and lipid-modifying targets on cholelithiasis.
作者: Lanlan Chen.;Wei Qiu.;Xiaodong Sun.;Menghan Gao.;Yuexuan Zhao.;Mingyue Li.;Zhongqi Fan.;Guoyue Lv.
来源: Gut. 2024年73卷3期521-532页
Different serum lipids and lipid-modifying targets should affect the risk of cholelithiasis differently, however, whether such effects are causal is still controversial and we aimed to answer this question.
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