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481. A preventive care strategy to reduce moderate or severe acute kidney injury after major surgery (BigpAK-2); a multinational, randomised clinical trial.
作者: Alexander Zarbock.;Marlies Ostermann.;Lui Forni.;Christian Bode.;Lennart Wild.;Christian Putensen.;Diego Parise Roux.;Elena Elías Martín.;Christian Arndt.;Tim Rahmel.;Silvia de Rosa.;Céline Monard.;Antoine G Schneider.;Adam Glass.;Mona Jung-König.;Stefano Romagnoli.;James Gossage.;Nuttha Lumlertgul.;Jan Gerrit Haaker.;Javier Ripollés-Melchor.;Savino Spadaro.;Antonio Siniscalchi.;Emmanuel Futier.;Lucie Aupetitgendre.;Irene Romero Bhathal.;Raquel García Álvarez.;Alice Bernard.;Peter Rosenberger.;Carola Wempe.;Mahan Sadjadi.;Melanie Meersch.;Karen Fischhuber.;Rinaldo Bellomo.;John A Kellum.;Thilo von Groote.; .
来源: Lancet. 2025年406卷10521期2782-2791页
Acute kidney injury (AKI) is a common and important complication of major surgery, yet recommended preventive care is rarely administered. We used urinary biomarkers to identify patients at high risk of AKI and implemented a preventive care strategy to reduce AKI within 72 h after major surgery.
482. Hyperemesis gravidarum.
作者: Melanie Nana.;Rebecca Painter.;Catherine Williamson.;Catherine Nelson-Piercy.
来源: Lancet. 2026年407卷10523期78-89页
Hyperemesis gravidarum describes nausea and vomiting in pregnancy severe enough to cause weight loss, dehydration, electrolyte imbalance, and nutritional deficiencies. The condition can render women so physically and mentally unwell that they are at increased risk of terminating a wanted pregnancy and experiencing suicidal ideation. Concerns regarding prescribing in pregnancy and inaccurate assumptions that the condition is self-limiting result in women being dismissed and having difficulty accessing appropriate care. Over the past decade, a wealth of literature has been published that gives new insights into the causes of hyperemesis gravidarum, the safety of antiemetic therapy, and short-term and long-term consequences for women with the condition and their children. This Review summarises the findings of this literature with the aim of informing decisions about the care of these women and future research priorities.
496. Translational social medicine for global health: introducing Cases in Global Social Medicine.
作者: Seth M Holmes.;Mayssa Rekhis.;Scott D Stonington.;Mirko Pasquini.;Luke Messac.;Eugene Raikhel.;Junko Kitanaka.;Valéria Macedo.;Paola Sesia.;Carlos Piñones Rivera.;Tinashe Goronga.;Salmaan Keshavjee.;Benson A Mulemi.;Margareta Matache.;Michael Marmot.
来源: Lancet. 2025年406卷10517期2306-2307页 500. Efficacy and safety of allogeneic CD19 CAR NK-cell therapy in systemic lupus erythematosus: a case series in China.
作者: Jie Gao.;Mengtao Li.;Ming Sun.;Yiyi Yu.;Ruina Kong.;Xia Xu.;Suxuan Liu.;Qian Chen.;Xiaofang Li.;Yang Wu.;Enshun Xu.;Jianmin Yang.;Dongbao Zhao.
来源: Lancet. 2026年406卷10522期2968-2979页
Lately, autologous CD19-targeting chimeric antigen receptor (CAR) T cells have shown excellent efficacy in treatment of autoimmune diseases, but with great safety concerns, such as infections. In this study, we aimed to evaluate the safety, tolerability, and efficacy of allogeneic CD19 CAR natural killer (NK)-cell therapy in patients with relapsed or refractory systemic lupus erythematosus (SLE).
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