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321. Location of endoscopic retrograde cholangiopancreatography impacts fluoroscopy time: a multi-institutional retrospective study at tertiary academic centers.
作者: Daniel Marino.;Kanhai Farrakhan.;Ethan Pearlstein.;Joao Filipe Monteiro.;Sohum Patwa.;Mouhand Mohamed.;Rei Mitsuyama.;Savan Kothadia.;Aastha Chokshi.;Harlan Rich.;Akwi Asombang.
来源: BMC Gastroenterol. 2025年25卷1期243页
Endoscopic retrograde cholangiopancreatography (ERCP) is important in the management of pancreatobiliary diseases and requires fluoroscopy resulting in radiation exposure to those involved. ERCP is performed in different hospital settings such as the endoscopy unit (EU), radiology suite (RS), and operating room (OR) depending on numerous factors. Our study examines the differences in duration of fluoroscopy time (FT) as a surrogate for radiation dosages between multiple unique settings.
322. Therapeutic Targeting of Oncogene-induced Transcription-Replication Conflicts in Pancreatic Ductal Adenocarcinoma.
作者: Shanna J Smith.;Fan Meng.;Robert G Lingeman.;Caroline M Li.;Min Li.;Galyah Boneh.;Toni T Seppälä.;Thuy Phan.;Haiqing Li.;Richard A Burkhart.;Vishwas Parekh.;Syed Rahmanuddin.;Laleh G Melstrom.;Robert J Hickey.;Vincent Chung.;Yilun Liu.;Linda H Malkas.;Mustafa Raoof.
来源: Gastroenterology. 2025年
Transcription-replication conflicts (TRCs) are a key source of replication stress in cancer, with pancreatic ductal adenocarcinoma (PDAC) showing uniquely high levels. This study investigated the mechanism, oncogene dependency, subtype specificity, and preclinical activity of the TRC-targeting molecule AOH1996 in PDAC models. Initial clinical evidence of AOH1996 activity in patients with PDAC is also provided.
323. Preventive Effect of Helicobacter pylori Treatment on Gastric Cancer Incidence and Mortality: A Korean Population Study.
Helicobacter pylori (H pylori) infection is a major risk factor for gastric cancer (GC); however, whether H pylori eradication (HPE) benefits the older population remains unclear. We compared GC incidence and mortality between H pylori-treated individuals and the general population, stratified by age.
324. Clinical practice guidelines for the diagnosis of constipation-predominant irritable bowel syndrome and functional constipation in adults: a scoping review.
作者: Jingyuan Luo.;Wing Lam Wendy To.;Qianqian Xu.;Jialing Zhang.;Yanfang Ma.;Sen Chow.;Danny J Yu.;Chun-Su Yuan.;Zhaoxiang Bian.
来源: BMC Gastroenterol. 2025年25卷1期234页
Constipation-predominant irritable bowel syndrome (IBS-C) and functional constipation (FC) are prevalent disorders with overlapping and fluctuating symptoms, which pose challenges for accurate diagnosis. This study aimed to assess the consistency of diagnostic criteria for IBS-C and FC in adults across clinical practice guidelines (CPGs).
325. An artificial intelligence model utilizing endoscopic ultrasonography for differentiating small and micro gastric stromal tumors from gastric leiomyomas.
作者: Ruifeng Duan.;Liwei Duan.;Xin Chen.;Min Liu.;Xiangyi Song.;Lijuan Wei.
来源: BMC Gastroenterol. 2025年25卷1期237页
Gastric stromal tumors (GSTs) and gastric leiomyomas (GLs) represent the primary subtypes of gastric submucosal tumors (SMTs) characterized by distinct biological characteristics and treatment modalities. The accurate differentiation between GSTs and GLs poses a significant clinical challenge. Recent advancements in artificial intelligence (AI) leveraging endoscopic ultrasonography (EUS) have demonstrated promising results in the categorization of larger-diameter SMTs (> 2.0 cm). However, the diagnostic capacity of AI models for micro-diameter SMTs (< 1.0 cm) remains uncertain due to limited imaging features. This study seeks to develop a specialized diagnostic model utilizing EUS images to differentiate small and micro GSTs from GLs effectively.
326. The fasting plasma glucose to high-density lipoprotein cholesterol ratio: a novel index for identifying NAFLD.
作者: Changhui Yu.;Shiming He.;Nan Peng.;Maobin Kuang.;Xin Huang.;Chao Wang.;Guotai Sheng.;Wei Wang.;Guobo Xie.;Yang Zou.
来源: BMC Gastroenterol. 2025年25卷1期236页
Previous research has indicated that the fasting plasma glucose to high-density lipoprotein cholesterol ratio (FHR) is a novel biomarker for assessing cardiovascular disease prognosis. The objective of this study is to investigate the potential relationship of FHR with non-alcoholic fatty liver disease (NAFLD).
327. Single-cell transcriptomic analysis reveals prognosis-related stromal signatures that potentiate stratification of patients with extrahepatic cholangiocarcinoma.
作者: Chen Ni.;Rulin Hua.;Yuanyuan Yang.;Jialu Liang.;Wentao Liu.;Linlin Wang.;Xiaohan Yao.;Anqi Li.;Long Yu.;Ruo Feng.;Dekang Lv.;Zhihai Qin.;Wenlong Zhai.
来源: BMC Gastroenterol. 2025年25卷1期235页
Extrahepatic cholangiocarcinoma (eCCA) is a rare but refractory cancer with dense desmoplasia. Prognosis-associated stromal cells in eCCA remain poorly characterized. Here, we profiled the tumor cellular composition and identified prognosis-related stromal signatures by single-cell RNA sequencing (scRNA-seq) in eCCA. ECCA patients were further stratified into different categories based on identified stromal signatures.
328. Metabolic Dysfunction-Associated Steatohepatitis Adipose Tissue Macrophages Secrete Extracellular Vesicles That Activate Liver Fibrosis in Obese Male Mice.
作者: Theresa V Rohm.;Felipe Castellani Gomes Dos Reis.;Karina Cunha E Rocha.;Roi Isaac.;Sean Strayer.;Cairo Murphy.;Gautam Bandyopadhyay.;Hong Gao.;Souradipta Ganguly.;Tram Nguyen.;Jinyue Wang.;John E Youhanna.;David Pack.;Xiao Liu.;Hyun Young Kim.;Ishtiaq Jeelani.;Debanjan Dhar.;Tatiana Kisseleva.;Wei Ying.;Jerrold M Olefsky.
来源: Gastroenterology. 2025年
Given the need for effective interventions in metabolic dysfunction-associated steatohepatitis (MASH), understanding the role of adipose tissue macrophage (ATM)-derived small extracellular vesicles (sEVs) is important. We aimed to evaluate the contribution of MASH-ATM-sEVs to the development of liver fibrosis in obese male mice.
329. Tumor Necrosis Factor-Like Ligand 1A/Death Receptor 3 Signaling Regulates the Generation of Pathogenic T Helper 9 Cells in Experimental Crohn's Disease.
作者: Paola Menghini.;Ludovica F Buttó.;Adrian Gomez-Nguyen.;Natalia Aladyshkina.;Kristine-Ann Buela.;Abdullah Osme.;Ricky Chan.;Hannah L Wargo.;Stefania De Santis.;Giorgos Bamias.;Theresa Pizarro.;Fabio Cominelli.
来源: Gastroenterology. 2025年
Death receptor 3 (DR3) and its ligand, tumor necrosis factor-like ligand 1A (TL1A), regulate the balance between effector and regulatory T cells in inflammatory bowel disease (IBD). Although interleukin 9 (IL9)-secreting T helper 9 (Th9) cells are linked to ulcerative colitis, their role in Crohn's disease (CD) is unclear. We investigated the role of DR3 signaling in Th9 cell differentiation in mouse models of CD-like ileitis and colitis.
330. KRASG12D Cells Override Homeostatic Cell Elimination Mechanisms in Adult Pancreas Via Wnt5a and Cell Dormancy.
作者: Beatriz Salvador-Barbero.;Markella Alatsatianos.;Jennifer P Morton.;Owen J Sansom.;Catherine Hogan.
来源: Gastroenterology. 2025年
The adult pancreas protects against cancer by actively expelling genetically mutated cells. Pancreatic cancer starts with cells carrying KRAS mutations; however, it is not clear how some KRAS mutant cells override cell elimination mechanisms to survive in tissues.
331. Efficacy and safety of PPAR agonists in primary biliary cholangitis: a systematic review and meta-analysis of Randomized Controlled Trials.
作者: Behrad Saeedian.;Nastaran Babajani.;Tannaz Bagheri.;Fatemeh Ojaghi Shirmard.;Seyed Morteza Pourfaraji.
来源: BMC Gastroenterol. 2025年25卷1期230页
Primary biliary cholangitis (PBC) is a chronic, progressive autoimmune liver disease. Some patients with PBC do not adequately respond to Ursodeoxycholic acid (UDCA) as a first-line treatment, putting them at an increased risk of disease progression. Peroxisome Proliferator-Activated Receptor (PPAR) agonists are emerging as promising therapeutic options for PBC. We aim to investigate the efficacy and safety of PPAR agonists in treating PBC patients.
332. High sensitivity C-reactive protein implicates heterogeneous metabolic phenotypes and severity in metabolic dysfunction associated-steatotic liver disease.
作者: Hao Wang.;Junzhao Ye.;Youpeng Chen.;Yanhong Sun.;Xiaorong Gong.;Hong Deng.;Zhiyong Dong.;Lishu Xu.;Xin Li.;Bihui Zhong.
来源: BMC Gastroenterol. 2025年25卷1期231页
Whether include high-sensitivity C-reactive protein (Hs-CRP) in diagnostic flow remains debatable during the updated definition to metabolic dysfunction-associated steatotic liver disease (MASLD) despite systemic inflammation contributes to the disease development and progression. We aimed to identify values of hs-CRP compared to other inflammatory markers derived from routine blood tests in MASLD.
333. Risk factors for enteral feeding intolerance in critically ill patients: an updated systematic review and meta-analysis.
This meta-analysis aimed to evaluate the factors influencing enteral nutrition feeding intolerance in critically ill patients.
334. Burden of gastrointestinal cancers in Asia, 1990-2019.
Gastrointestinal (GI) cancers are a major cause of morbidity and mortality worldwide. However, there has been no comprehensive assessment of GI cancers in Asia.
335. Large Language Model-Supported Systematic Reviews to Augment Clinical Guideline Development: An American Gastroenterological Association Pilot.
作者: Sunny Chung.;Bahar Saberzadeh-Ardestani.;Gaurav Nigam.;Yuhong Yuan.;Siddharth Singh.;Dennis Shung.
来源: Gastroenterology. 2025年 336. Association between fibrosis-4 index (FIB-4) and gallstones: an analysis of the NHANES 2017-2020 cross-sectional study.
作者: Huqiang Dong.;Zufa Zhang.;Chang Fu.;Mixue Guo.;Haifeng Zhang.;Xintian Cai.;Hongping Cheng.
来源: BMC Gastroenterol. 2025年25卷1期229页
Gallstones are a common digestive disorder, yet the association between the fibrosis-4 index (FIB-4) and gallstone formation remains poorly understood. This study explores the link between FIB-4 levels and gallstone prevalence among US adults.
337. Iceball growth 3D simulation model based on finite element method for hepatic cryoablation planning.
作者: Shengwei Li.;Yumeng Zhang.;Fanyu Zhou.;Sheng Xu.;Yufeng Wang.;Lin Cheng.;Zhixin Bie.;Bin Li.;Xiao-Guang Li.
来源: BMC Gastroenterol. 2025年25卷1期227页
Cryoablation simulation based on Finite Element Method (FEM) can facilitate preoperative planning for liver tumors. However, it has limited application in clinical practice due to its time-consuming process and improvable accuracy. We aimed to propose a FEM-based simulation model for rapid and accurate prediction of the iceball size during the hepatic cryofreezing cycle.
338. Triglyceride-glucose index and triglyceride-to-high-density lipoprotein cholesterol ratio in predicting severity of acute pancreatitis: a cross-sectional clinical study.
The aim of this study is to investigate the correlation of triglyceride-glucose (TyG) index and triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio with acute pancreatitis (AP), and to compare the predictive value of the two indexes for severe AP (SAP).
339. Long transparent cap-assisted clip closure technique: a new choice for gastrointestinal defect closure.
作者: Nan Dai.;Changqing Guo.;Shanshan Zhu.;Saif Ullah.;Jingwen Zhang.;Ping Liu.;Fangbin Zhang.;Xinguang Cao.
来源: BMC Gastroenterol. 2025年25卷1期228页
To evaluate the safety and effectiveness of the novel long transparent cap-assisted clip closure technique in closing gastrointestinal defects.
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