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275. Surgical fixation versus non-surgical care for children with a displaced medial epicondyle fracture of the elbow (the SCIENCE study): a multicentre, randomised controlled, superiority trial and economic evaluation.
作者: Daniel C Perry.;Juul Achten.;Alex Zimmermann.;Rebecca Kandiyali.;Duncan Appelbe.;James G Wright.;David Ferguson.;Kemble Wang.;Nichola Wilson.;Amy Moscrop.;James Mason.;Daphne Kounali.;Matthew L Costa.; .
来源: Lancet. 2026年407卷10528期577-586页
Displaced medial epicondyle fractures are among the most controversial injuries in children, with increasing trends towards surgical fixation despite little supporting evidence. Approximately half of affected children undergo surgical fixation, while others receive non-surgical care. The SCIENCE trial aimed to determine whether surgical fixation to restore the position of the bone provides superior functional outcomes and is cost-effective compared with non-surgical care.
276. Leprosy.
作者: Nelson Iván Agudelo Higuita.;Charlotte Avanzi.;Andrés F Henao-Martínez.;Tanvi P Honap.;Neema Bendera.;Carlos Franco-Paredes.;Rie R Yotsu.;Mendrika Rakotoarisaona.;Natarajan Manimozhi.;John S Spencer.
来源: Lancet. 2026年407卷10530期805-819页
Leprosy, also known as Hansen's disease, is a curable granulomatous condition caused by Mycobacterium leprae or Mycobacterium lepromatosis, disproportionately affecting impoverished communities across the globe. The bacteria's tropism for dermal histiocytes, endothelial cells, and Schwann cells causes neuronal and dermal damage that often results in disability, permanent disfigurement, stigma, and social exclusion. Despite important achievements in the understanding of the disease, its elimination has been hampered by the scarcity of sensitive diagnostic tools, suboptimal integration and implementation of coordinated and financially stable preventive interventions, persistent stigmatisation, and failure to efficiently and sustainably address the socioeconomic and demographic factors associated with an increased risk of leprosy. In this Seminar, we provide an update on key public health and clinical aspects of the disease.
277. The Lancet Commission on a citizen-centred health system for India.
作者: Vikram Patel.;Anuska Kalita.;Kheya Melo Furtado.;Nachiket Mor.;Shubhangi Bhadada.;Sandra Albert.;Hasna Ashraf.;Satchit Balsari.;Indu Bhushan.;Vijay Chandru.;Mirai Chatterjee.;Sarika Chaturvedi.;Raghu Dharmaraju.;Atul Gupta.;Kiran Mazumdar-Shaw.;Gautam I Menon.;Arnab Mukherji.;Poonam Muttreja.;Anjali Nambiar.;Thelma Narayan.;Bhushan Patwardhan.;Tejasvi Ravi.;Sharad Sharma.;Devi Shetty.;Sudheer Kumar Shukla.;S V Subramanian.;Leila Varkey.;Sandhya Venkateswaran.;Siddhesh Zadey.;Tarun Khanna.
来源: Lancet. 2026年407卷10526期388-468页 |