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2521. Incidence of faecal occult blood test interval cancers in population-based colorectal cancer screening: a systematic review and meta-analysis.
作者: Els Wieten.;Eline H Schreuders.;Esmée J Grobbee.;Daan Nieboer.;Wichor M Bramer.;Iris Lansdorp-Vogelaar.;Marco J Bruno.;Ernst J Kuipers.;Manon C W Spaander.
来源: Gut. 2019年68卷5期873-881页
Faecal immunochemical tests (FITs) are replacing guaiac faecal occult blood tests (gFOBTs) for colorectal cancer (CRC) screening. Incidence of interval colorectal cancer (iCRC) following a negative stool test result is not yet known. We aimed to compare incidence of iCRC following a negative FIT or gFOBT.
2522. Incidence, morbidity and mortality of patients with achalasia in England: findings from a study of nationwide hospital and primary care data.
作者: Philip R Harvey.;Tom Thomas.;Joht S Chandan.;Jemma Mytton.;Ben Coupland.;Neeraj Bhala.;Felicity Evison.;Prashant Patel.;Krishnarajah Nirantharakumar.;Nigel J Trudgill.
来源: Gut. 2019年68卷5期790-795页
Achalasia is an uncommon condition characterised by failed lower oesophageal sphincter relaxation. Data regarding its incidence, prevalence, disease associations and long-term outcomes are very limited.
2524. Major microbiota dysbiosis in severe obesity: fate after bariatric surgery.
作者: Judith Aron-Wisnewsky.;Edi Prifti.;Eugeni Belda.;Farid Ichou.;Brandon D Kayser.;Maria Carlota Dao.;Eric O Verger.;Lyamine Hedjazi.;Jean-Luc Bouillot.;Jean-Marc Chevallier.;Nicolas Pons.;Emmanuelle Le Chatelier.;Florence Levenez.;Stanislav Dusko Ehrlich.;Joel Dore.;Jean-Daniel Zucker.;Karine Clément.
来源: Gut. 2019年68卷1期70-82页
Decreased gut microbial gene richness (MGR) and compositional changes are associated with adverse metabolism in overweight or moderate obesity, but lack characterisation in severe obesity. Bariatric surgery (BS) improves metabolism and inflammation in severe obesity and is associated with gut microbiota modifications. Here, we characterised severe obesity-associated dysbiosis (ie, MGR, microbiota composition and functional characteristics) and assessed whether BS would rescue these changes.
2526. Subtypes of Barrett's oesophagus and oesophageal adenocarcinoma based on genome-wide methylation analysis.
作者: Ming Yu.;Sean K Maden.;Matthew Stachler.;Andrew M Kaz.;Jessica Ayers.;Yuna Guo.;Kelly T Carter.;Amber Willbanks.;Tai J Heinzerling.;Rachele M O'Leary.;Xinsen Xu.;Adam Bass.;Apoorva K Chandar.;Amitabh Chak.;Robin Elliott.;Joseph E Willis.;Sanford D Markowitz.;William M Grady.
来源: Gut. 2019年68卷3期389-399页
To identify and characterise DNA methylation subtypes in oesophageal adenocarcinoma (EAC) and its precursor Barrett's oesophagus (BE).
2528. Surveillance of premalignant gastric lesions: a multicentre prospective cohort study from low incidence regions.
作者: Wouter J den Hollander.;I Lisanne Holster.;Caroline M den Hoed.;Lisette G Capelle.;Tjon J Tang.;Marie-Paule Anten.;Ingrid Prytz-Berset.;Ellen M Witteman.;Frank Ter Borg.;Gijsbert den Hartog.;Marco J Bruno.;Maikel Petrus Peppelenbosch.;Wilco Lesterhuis.;Michael Doukas.;Ernst J Kuipers.;Manon C W Spaander.
来源: Gut. 2019年68卷4期585-593页
International guidelines recommend endoscopic surveillance of premalignant gastric lesions. However, the diagnostic yield and preventive effect require further study. We therefore aimed to assess the incidence of neoplastic progression and to assess the ability of various tests to identify patients most at risk for progression.
2530. Effect of anticoagulants and NSAIDs on accuracy of faecal immunochemical tests (FITs) in colorectal cancer screening: a systematic review and meta-analysis.
作者: Stella A V Nieuwenburg.;Fanny E R Vuik.;Marieke J H A Kruip.;Ernst J Kuipers.;Manon C W Spaander.
来源: Gut. 2019年68卷5期866-872页
Most colorectal cancer (CRC) screening programmes are nowadays based on faecal immunochemical testing (FIT). Eligible subjects often use oral anticoagulants (OACs) or non-steroidal anti-inflammatory drugs (NSAIDs), which could possibly stimulate bleeding from both benign and premalignant lesions in the colon. The aim of this meta-analysis was to study the effect of OACs and NSAIDs use on FIT performance.
2532. Gut microbiota metabolites, amino acid metabolites and improvements in insulin sensitivity and glucose metabolism: the POUNDS Lost trial.
作者: Yoriko Heianza.;Dianjianyi Sun.;Xiang Li.;Joseph A DiDonato.;George A Bray.;Frank M Sacks.;Lu Qi.
来源: Gut. 2019年68卷2期263-270页
Alterations in gut microbiota have been linked to host insulin resistance, diabetes and impaired amino acid metabolism. We investigated whether changes in gut microbiota-dependent metabolite of trimethylamine N-oxide (TMAO) and its nutrient precursors (choline and L-carnitine) were associated with improvements in glucose metabolism and diabetes-related amino acids in a weight-loss diet intervention.
2533. Association between delayed gastric emptying and upper gastrointestinal symptoms: a systematic review and meta-analysis.
作者: Priya Vijayvargiya.;Sina Jameie-Oskooei.;Michael Camilleri.;Victor Chedid.;Patricia J Erwin.;Mohammad Hassan Murad.
来源: Gut. 2019年68卷5期804-813页
The relationship between delayed gastric emptying and upper GI symptoms (UGI Sx) is controversial.
2534. Functional abdominal pain and discomfort (IBS) is not associated with faecal microbiota composition in the general population.
作者: Fabian Frost.;Tim Kacprowski.;Malte Christoph Rühlemann.;Andre Franke.;Femke-Anouska Heinsen.;Uwe Völker.;Henry Völzke.;Ali A Aghdassi.;Julia Mayerle.;Frank U Weiss.;Georg Homuth.;Markus M Lerch.
来源: Gut. 2019年68卷6期1131-1133页 2536. Non-superiority of lumen-apposing metal stents over plastic stents for drainage of walled-off necrosis in a randomised trial.
作者: Ji Young Bang.;Udayakumar Navaneethan.;Muhammad K Hasan.;Bryce Sutton.;Robert Hawes.;Shyam Varadarajulu.
来源: Gut. 2019年68卷7期1200-1209页
Although lumen-apposing metal stents (LAMS) are increasingly used for drainage of walled-off necrosis (WON), their advantage over plastic stents is unclear. We compared efficacy of LAMS and plastic stents for WON drainage.
2537. Expansion of IL-23 receptor bearing TNFR2+ T cells is associated with molecular resistance to anti-TNF therapy in Crohn's disease.
作者: Heike Schmitt.;Ulrike Billmeier.;Walburga Dieterich.;Timo Rath.;Sophia Sonnewald.;Stephen Reid.;Simon Hirschmann.;Kai Hildner.;Maximilian J Waldner.;Jonas Mudter.;Arndt Hartmann.;Robert Grützmann.;Clemens Neufert.;Tino Münster.;Markus F Neurath.;Raja Atreya.
来源: Gut. 2019年68卷5期814-828页
Anti-tumour necrosis factor (TNF) antibodies are successfully used for treatment of Crohn's disease. Nevertheless, approximately 40% of patients display failure to anti-TNF therapy. Here, we characterised molecular mechanisms that are associated with endoscopic resistance to anti-TNF therapy.
2538. Effect of Huaier granule on recurrence after curative resection of HCC: a multicentre, randomised clinical trial.
作者: Qian Chen.;Chang Shu.;Arian D Laurence.;Yan Chen.;Bao-Gang Peng.;Zuo-Jun Zhen.;Jian-Qiang Cai.;Yi-Tao Ding.;Le-Qun Li.;Yu-Bao Zhang.;Qi-Chang Zheng.;Ge-Liang Xu.;Bo Li.;Wei-Ping Zhou.;Shou-Wang Cai.;Xi-Yan Wang.;Hao Wen.;Xin-Yu Peng.;Xue-Wen Zhang.;Chao-Liu Dai.;Ping Bie.;Bao-Cai Xing.;Zhi-Ren Fu.;Lian-Xin Liu.;Yi Mu.;Ling Zhang.;Qi-Shun Zhang.;Bin Jiang.;Hai-Xin Qian.;Yi-Jun Wang.;Jing-Feng Liu.;Xi-Hu Qin.;Qiang Li.;Ping Yin.;Zhi-Wei Zhang.;Xiao-Ping Chen.
来源: Gut. 2018年67卷11期2006-2016页
There is little evidence that adjuvant therapy after radical surgical resection of hepatocellular carcinoma (HCC) improves recurrence-free survival (RFS) or overall survival (OS). We conducted a multicentre, randomised, controlled, phase IV trial evaluating the benefit of an aqueous extract of Trametes robinophila Murr (Huaier granule) to address this unmet need.
2540. Prophylactic angiographic embolisation after endoscopic control of bleeding to high-risk peptic ulcers: a randomised controlled trial.
作者: James Y W Lau.;Rapat Pittayanon.;Ka-Tak Wong.;Nutcha Pinjaroen.;Philip Wai Yan Chiu.;Rungsun Rerknimitr.;Ingrid Lisanne Holster.;Ernst J Kuipers.;Kai-Chun Wu.;Kim W L Au.;Francis K L Chan.;Joseph J Y Sung.
来源: Gut. 2019年68卷5期796-803页
In the management of patients with bleeding peptic ulcers, recurrent bleeding is associated with high mortality. We investigated if added angiographic embolisation after endoscopic haemostasis to high-risk ulcers could reduce recurrent bleeding.
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