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2161. Integrated paired-end enhancer profiling and whole-genome sequencing reveals recurrent CCNE1 and IGF2 enhancer hijacking in primary gastric adenocarcinoma.
作者: Wen Fong Ooi.;Amrita M Nargund.;Kevin Junliang Lim.;Shenli Zhang.;Manjie Xing.;Amit Mandoli.;Jing Quan Lim.;Shamaine Wei Ting Ho.;Yu Guo.;Xiaosai Yao.;Suling Joyce Lin.;Tannistha Nandi.;Chang Xu.;Xuewen Ong.;Minghui Lee.;Angie Lay-Keng Tan.;Yue Ning Lam.;Jing Xian Teo.;Atsushi Kaneda.;Kevin P White.;Weng Khong Lim.;Steven G Rozen.;Bin Tean Teh.;Shang Li.;Anders J Skanderup.;Patrick Tan.
来源: Gut. 2020年69卷6期1039-1052页
Genomic structural variations (SVs) causing rewiring of cis-regulatory elements remain largely unexplored in gastric cancer (GC). To identify SVs affecting enhancer elements in GC (enhancer-based SVs), we integrated epigenomic enhancer profiles revealed by paired-end H3K27ac ChIP-sequencing from primary GCs with tumour whole-genome sequencing (WGS) data (PeNChIP-seq/WGS).
2163. Real-time use of artificial intelligence in the evaluation of cancer in Barrett's oesophagus.
作者: Alanna Ebigbo.;Robert Mendel.;Andreas Probst.;Johannes Manzeneder.;Friederike Prinz.;Luis A de Souza.;Joao Papa.;Christoph Palm.;Helmut Messmann.
来源: Gut. 2020年69卷4期615-616页 2165. Quantitative fluorescence endoscopy: an innovative endoscopy approach to evaluate neoadjuvant treatment response in locally advanced rectal cancer.
作者: Jolien J J Tjalma.;Marjory Koller.;Matthijs D Linssen.;Elmire Hartmans.;Steven J de Jongh.;Annelies Jorritsma-Smit.;Arend Karrenbeld.;Elisabeth G de Vries.;Jan H Kleibeuker.;Jan Pieter Pennings.;Klaas Havenga.;Patrick Hjh Hemmer.;Geke Ap Hospers.;Boudewijn van Etten.;Vasilis Ntziachristos.;Gooitzen M van Dam.;Dominic J Robinson.;Wouter B Nagengast.
来源: Gut. 2020年69卷3期406-410页 2166. Rilpivirine attenuates liver fibrosis through selective STAT1-mediated apoptosis in hepatic stellate cells.
作者: Alberto Martí-Rodrigo.;Fernando Alegre.;Ángela B Moragrega.;Francisco García-García.;Pablo Martí-Rodrigo.;Anabel Fernández-Iglesias.;Jordi Gracia-Sancho.;Nadezda Apostolova.;Juan V Esplugues.;Ana Blas-García.
来源: Gut. 2020年69卷5期920-932页
Liver fibrosis constitutes a major health problem worldwide due to its rapidly increasing prevalence and the lack of specific and effective treatments. Growing evidence suggests that signalling through cytokine-activated Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathways regulates liver fibrosis and regeneration. Rilpivirine (RPV) is a widely used anti-HIV drug not reported to produce hepatotoxicity. We aimed to describe the potential hepatoprotective effects of RPV in different models of chronic liver injury, focusing on JAK-STAT signalling regulation.
2168. CDK12 inhibition mediates DNA damage and is synergistic with sorafenib treatment in hepatocellular carcinoma.
作者: Cun Wang.;Hui Wang.;Cor Lieftink.;Aimee du Chatinier.;Dongmei Gao.;Guangzhi Jin.;Haojie Jin.;Roderick L Beijersbergen.;Wenxin Qin.;René Bernards.
来源: Gut. 2020年69卷4期727-736页
Hepatocellular carcinoma (HCC) is one of the most frequent malignancies and a major leading cause of cancer-related deaths worldwide. Several therapeutic options like sorafenib and regorafenib provide only modest survival benefit to patients with HCC. This study aims to identify novel druggable candidate genes for patients with HCC.
2169. Anti-TNF therapy in IBD exerts its therapeutic effect through macrophage IL-10 signalling.
作者: Pim J Koelink.;Felicia M Bloemendaal.;Bofeng Li.;Liset Westera.;Esther W M Vogels.;Manon van Roest.;Anouk K Gloudemans.;Angelique B van 't Wout.;Hannelie Korf.;Séverine Vermeire.;Anje A Te Velde.;Cyriel Y Ponsioen.;Geert Ram D'Haens.;J Sjef Verbeek.;Terrence L Geiger.;Manon E Wildenberg.;Gijs R van den Brink.
来源: Gut. 2020年69卷6期1053-1063页
Macrophage interleukin (IL)-10 signalling plays a critical role in the maintenance of a regulatory phenotype that prevents the development of IBD. We have previously found that anti-tumour necrosis factor (TNF) monoclonal antibodies act through Fcγ-receptor (FcγR) signalling to promote repolarisation of proinflammatory intestinal macrophages to a CD206+ regulatory phenotype. The role of IL-10 in anti-TNF-induced macrophage repolarisation has not been examined.
2171. British Society of Gastroenterology position statement on patient experience of GI endoscopy.
作者: Colin J Rees.;Tim M Trebble.;Christian Von Wagner.;Zoe Clapham.;Paul Hewitson.;Hugh Barr.;Simon Everett.;Helen Griffiths.;Manu Nayar.;Kofi Oppong.;Stuart Riley.;John Stebbing.;Siwan Thomas-Gibson.;Roisin Bevan.
来源: Gut. 2020年69卷9期1页 2175. Global patterns and trends in colorectal cancer incidence in young adults.
作者: Rebecca L Siegel.;Lindsey A Torre.;Isabelle Soerjomataram.;Richard B Hayes.;Freddie Bray.;Thomas K Weber.;Ahmedin Jemal.
来源: Gut. 2019年68卷12期2179-2185页
Early-onset colorectal cancer (CRC) is increasing in the USA despite rapid declines in older ages. Similar patterns are reported in Australia and Canada, but a comprehensive global analysis of contemporary data is lacking.
2178. Single-cell transcriptional analyses of spasmolytic polypeptide-expressing metaplasia arising from acute drug injury and chronic inflammation in the stomach.
作者: Kevin A Bockerstett.;Scott A Lewis.;Kyle J Wolf.;Christine N Noto.;Nicholas M Jackson.;Eric L Ford.;Tae-Hyuk Ahn.;Richard J DiPaolo.
来源: Gut. 2020年69卷6期1027-1038页
Spasmolytic polypeptide-expressing metaplasia (SPEM) is a regenerative lesion in the gastric mucosa and is a potential precursor to intestinal metaplasia/gastric adenocarcinoma in a chronic inflammatory setting. The goal of these studies was to define the transcriptional changes associated with SPEM at the individual cell level in response to acute drug injury and chronic inflammatory damage in the gastric mucosa.
2180. Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer's disease animal model.
作者: Min-Soo Kim.;Yoonhee Kim.;Hyunjung Choi.;Woojin Kim.;Sumyung Park.;Dongjoon Lee.;Dong Kyu Kim.;Haeng Jun Kim.;Hayoung Choi.;Dong-Wook Hyun.;June-Young Lee.;Eun Young Choi.;Dong-Sup Lee.;Jin-Woo Bae.;Inhee Mook-Jung.
来源: Gut. 2020年69卷2期283-294页
Cerebral amyloidosis and severe tauopathy in the brain are key pathological features of Alzheimer's disease (AD). Despite a strong influence of the intestinal microbiota on AD, the causal relationship between the gut microbiota and AD pathophysiology is still elusive.
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