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2081. Impairment of spermatogenesis and sperm motility by the high-fat diet-induced dysbiosis of gut microbes.
作者: Ning Ding.;Xin Zhang.;Xue Di Zhang.;Jun Jing.;Shan Shan Liu.;Yun Ping Mu.;Li Li Peng.;Yun Jing Yan.;Geng Miao Xiao.;Xin Yun Bi.;Hao Chen.;Fang Hong Li.;Bing Yao.;Allan Z Zhao.
来源: Gut. 2020年69卷9期1608-1619页
High-fat diet (HFD)-induced metabolic disorders can lead to impaired sperm production. We aim to investigate if HFD-induced gut microbiota dysbiosis can functionally influence spermatogenesis and sperm motility.
2082. Intrahepatic bacterial metataxonomic signature in non-alcoholic fatty liver disease.
作者: Silvia Sookoian.;Adrian Salatino.;Gustavo Osvaldo Castaño.;Maria Silvia Landa.;Cinthia Fijalkowky.;Martin Garaycoechea.;Carlos Jose Pirola.
来源: Gut. 2020年69卷8期1483-1491页
We aimed to characterise the liver tissue bacterial metataxonomic signature in two independent cohorts of patients with biopsy-proven non-alcoholic fatty liver disease (NAFLD) diagnosis, as differences in the host phenotypic features-from moderate to severe obesity-may be associated with significant changes in the microbial DNA profile.
2083. Adherence to a Mediterranean diet is associated with a lower risk of later-onset Crohn's disease: results from two large prospective cohort studies.
作者: Hamed Khalili.;Niclas Håkansson.;Simon S Chan.;Ye Chen.;Paul Lochhead.;Jonas F Ludvigsson.;Andrew T Chan.;Andrew R Hart.;Ola Olén.;Alicja Wolk.
来源: Gut. 2020年69卷9期1637-1644页
To examine the relationship between Mediterranean diet and risk of later-onset Crohn's disease (CD) or ulcerative colitis (UC).
2084. Gut dysbiosis induces the development of pre-eclampsia through bacterial translocation.
作者: Xia Chen.;Pan Li.;Mian Liu.;Huimin Zheng.;Yan He.;Mu-Xuan Chen.;Wenli Tang.;Xiaojing Yue.;Yongxin Huang.;Lingling Zhuang.;Zhijian Wang.;Mei Zhong.;Guibao Ke.;Haoyue Hu.;Yinglin Feng.;Yun Chen.;Yanhong Yu.;Hongwei Zhou.;Liping Huang.
来源: Gut. 2020年69卷3期513-522页
Pre-eclampsia (PE) is one of the malignant metabolic diseases that complicate pregnancy. Gut dysbiosis has been identified for causing metabolic diseases, but the role of gut microbiome in the pathogenesis of PE remains unknown.
2085. Recent advances in alcohol-related liver disease (ALD): summary of a Gut round table meeting.
作者: Matias A Avila.;Jean-François Dufour.;Alexander L Gerbes.;Fabien Zoulim.;Ramon Bataller.;Patrizia Burra.;Helena Cortez-Pinto.;Bin Gao.;Ian Gilmore.;Philippe Mathurin.;Christophe Moreno.;Vladimir Poznyak.;Bernd Schnabl.;Gyongyi Szabo.;Maja Thiele.;Mark R Thursz.
来源: Gut. 2020年69卷4期764-780页
Alcohol-related liver disease (ALD), which includes a range of disorders of different severity and is one of the most prevalent types of liver disease worldwide, has recently regained increased attention. Among other reasons, the realisation that any alcohol intake, regardless of type of beverage represents a health risk, and the new therapeutic strategies tested in recently published or undergoing clinical trials spur scientific interest in this area.In April 2019, Gut convened a round table panel of experts during the European Association for the Study of the Liver International Liver Congress in Vienna to discuss critical and up-to-date issues and clinical trial data regarding ALD, its epidemiology, diagnosis, management, pathomechanisms, possible future treatments and prevention. This paper summarises the discussion and its conclusions.
2089. Intestinal ultrasound for monitoring therapeutic response in patients with ulcerative colitis: results from the TRUST&UC study.
作者: Christian Maaser.;Frauke Petersen.;Ulf Helwig.;Imma Fischer.;Alexander Roessler.;Stefan Rath.;Dorothee Lang.;Torsten Kucharzik.; .; .
来源: Gut. 2020年69卷9期1629-1636页
Prospective evaluation of intestinal ultrasound (IUS) for disease monitoring of patients with ulcerative colitis (UC) in routine medical practice.
2090. Effect of Helicobacter pylori on gastrointestinal microbiota: a population-based study in Linqu, a high-risk area of gastric cancer.
作者: Yang Guo.;Yang Zhang.;Markus Gerhard.;Juan-Juan Gao.;Raquel Mejias-Luque.;Lian Zhang.;Michael Vieth.;Jun-Ling Ma.;Monther Bajbouj.;Stepan Suchanek.;Wei-Dong Liu.;Kurt Ulm.;Michael Quante.;Zhe-Xuan Li.;Tong Zhou.;Roland Schmid.;Meinhard Classen.;Wen-Qing Li.;Wei-Cheng You.;Kai-Feng Pan.
来源: Gut. 2020年69卷9期1598-1607页
Gastrointestinal microbiota may be involved in Helicobacter pylori-associated gastric cancer development. The aim of this study was to explore the possible microbial mechanisms in gastric carcinogenesis and potential dysbiosis arising from H. pylori infection.
2091. Histopathologist features predictive of diagnostic concordance at expert level among a large international sample of pathologists diagnosing Barrett's dysplasia using digital pathology.
作者: Myrtle J van der Wel.;Helen G Coleman.;Jacques J G H M Bergman.;Marnix Jansen.;Sybren L Meijer.; .
来源: Gut. 2020年69卷5期811-822页
Guidelines mandate expert pathology review of Barrett's oesophagus (BO) biopsies that reveal dysplasia, but there are no evidence-based standards to corroborate expert reviewer status. We investigated BO concordance rates and pathologist features predictive of diagnostic discordance.
2092. Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study.
作者: Magdy El-Salhy.;Jan Gunnar Hatlebakk.;Odd Helge Gilja.;Anja Bråthen Kristoffersen.;Trygve Hausken.
来源: Gut. 2020年69卷5期859-867页
Faecal microbiota transplantation (FMT) from healthy donors to patients with irritable bowel syndrome (IBS) has been attempted in two previous double-blind, placebo-controlled studies. While one of those studies found improvement of the IBS symptoms, the other found no effect. The present study was conducted to clarify these contradictory findings.
2097. Number needed to treat with ursodeoxycholic acid therapy to prevent liver transplantation or death in primary biliary cholangitis.
作者: Maren H Harms.;Rozanne C de Veer.;Willem J Lammers.;Christophe Corpechot.;Douglas Thorburn.;Harry L A Janssen.;Keith D Lindor.;Palak J Trivedi.;Gideon M Hirschfield.;Albert Pares.;Annarosa Floreani.;Marlyn J Mayo.;Pietro Invernizzi.;Pier Maria Battezzati.;Frederik Nevens.;Cyriel Y Ponsioen.;Andrew L Mason.;Kris V Kowdley.;Bettina E Hansen.;Henk R van Buuren.;Adriaan J van der Meer.
来源: Gut. 2020年69卷8期1502-1509页
The clinical benefit of ursodeoxycholic acid (UDCA) in primary biliary cholangitis (PBC) has never been reported in absolute measures. The aim of this study was to assess the number needed to treat (NNT) with UDCA to prevent liver transplantation (LT) or death among patients with PBC.
2099. Long-term prognosis of ulcerative colitis and its temporal changes between 1986 and 2015 in a population-based cohort in the Songpa-Kangdong district of Seoul, Korea.
作者: Jae Myung Cha.;Sang Hyoung Park.;Kyoung Hoon Rhee.;Sung Noh Hong.;Young-Ho Kim.;Seung In Seo.;Kyung Ho Kim.;Seung Kyu Jeong.;Ji Hyun Lee.;Sun Yong Park.;Hyunju Park.;Joo Sung Kim.;Jong Pil Im.;Hyuk Yoon.;Sung Hoon Kim.;Jisun Jang.;Jeong Hwan Kim.;Seong O Suh.;Young Kyun Kim.;Byong Duk Ye.;Suk-Kyun Yang.
来源: Gut. 2020年69卷8期1432-1440页
No population-based study has evaluated the natural course of UC over three decades in non-Caucasians. We aimed to assess the long-term natural course of Korean patients with UC in a population-based cohort.
2100. USF1 defect drives p53 degradation during Helicobacter pylori infection and accelerates gastric carcinogenesis.
作者: Lionel Costa.;Sébastien Corre.;Valérie Michel.;Krysten Le Luel.;Julien Fernandes.;Jason Ziveri.;Gregory Jouvion.;Anne Danckaert.;Nicolas Mouchet.;David Da Silva Barreira.;Javier Torres.;Margarita Camorlinga.;Mario Milco D'Elios.;Laurence Fiette.;Hilde De Reuse.;Marie-Dominique Galibert.;Eliette Touati.
来源: Gut. 2020年69卷9期1582-1591页
Helicobacter pylori (Hp) is a major risk factor for gastric cancer (GC). Hp promotes DNA damage and proteasomal degradation of p53, the guardian of genome stability. Hp reduces the expression of the transcription factor USF1 shown to stabilise p53 in response to genotoxic stress. We investigated whether Hp-mediated USF1 deregulation impacts p53-response and consequently genetic instability. We also explored in vivo the role of USF1 in gastric carcinogenesis.
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