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1. Effects of ultrasonic rapid processing method on the protein, DNA, and RNA in paraffin-embedded tissues.
作者: Xiaohong Li.;Jiadi Luo.;Qingchun Liang.;Zhongyi Tong.
来源: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2025年50卷4期664-674页
The traditional processing method for paraffin-embedded tissues is time-consuming, while the ultrasonic rapid processing method has a short processing time. However, its effects on tissue proteins, DNA, and RNA remain unclear. This study aims to evaluate the effects of the ultrasonic rapid processing method on proteins, DNA, and RNA in paraffin-embedded tissues through hematoxylin and eosin (HE) staining, immunohistochemical staining, and molecular pathological detection.
2. Deep learning algorithm for pathological grading of renal cell carcinoma based on multi-phase enhanced CT.
作者: Haozhong Chen.;Jun Liu.;Kai Deng.;Xilong Mei.;Dehong Peng.;Enhua Xiao.
来源: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2025年50卷4期651-663页
Renal cell carcinoma (RCC) is a malignant renal tumor that poses a significant threat to patient health. Accurate preoperative pathological grading plays a crucial role in determining the appropriate treatment for this disease. Currently, deep learning technology has become an important method for pathological grading of RCC. However, existing methods primarily rely on single-phase computed tomography (CT) imaging for analysis and prediction, which has limitations such as missing small lesions, one-sided evaluation, and local focusing issues. Therefore, this study proposes a multi-modal deep learning algorithm that integrates multi-phase enhanced CT images with clinical variable data, aiming to provide a basis for predicting the pathological grading of RCC.
3. [Robot-assisted laparoscopic inferior vena cava segmental resection for renal tumor with tumor thrombus invading the vascular wall].
作者: S Liu.;Z Liu.;Y Guan.;G Wang.;X Tian.;H Zhang.;L Liu.;L Ma.;S Zhang.
来源: Beijing Da Xue Xue Bao Yi Xue Ban. 2025年57卷4期796-802页
To evaluate the safety and oncological outcomes of robot-assisted laparoscopic inferior vena cava (IVC) segmental resection in renal tumor with IVC tumor thrombus (IVCTT).
4. [A retrospective matching study of partial nephrectomy and radical nephrectomy for pathological T3a stage renal cell carcinoma].
作者: Z Zhou.;L Ge.;F Zhang.;S Deng.;Y Yan.;H Zhang.;G Wang.;L Liu.;Y Huang.;S Zhang.
来源: Beijing Da Xue Xue Bao Yi Xue Ban. 2025年57卷4期704-710页
To evaluate the long-term oncological outcomes of partial nephrectomy (PN) in patients with renal cell carcinoma (RCC) who were clinically staged as clinical T1 (cT1) preoperatively but upstaged to pathological T3a (pT3a) after surgery.
5. [A preoperative prediction model for pelvic lymph node metastasis in prostate cancer: Integrating clinical characteristics and multiparametric MRI].
作者: Z Wang.;S Yu.;H Zheng.;J Tao.;Y Fan.;X Zhang.
来源: Beijing Da Xue Xue Bao Yi Xue Ban. 2025年57卷4期684-691页
To analyze the clinical features associated with pelvic lymph node metastasis (PLNM) in prostate cancer and to construct a preoperative prediction model for PLNM, thereby reducing unnecessary extended pelvic lymph node dissection (ePLND).
6. [Clinicopathological features and survival analysis of TFE3-rearranged renal cell carcinoma with venous tumor thrombus].
作者: Z Zhang.;M Lu.;Y Sun.;J Dong.;X Hou.;C Xiao.;G Wang.;X Tian.;L Ma.;H Zhang.;S Zhang.
来源: Beijing Da Xue Xue Bao Yi Xue Ban. 2025年57卷4期650-661页
To review the clinicopathological features of TFE3-rearranged renal cell carcinoma (TFE3-RCC) with venous tumor thrombus (VT) (TFE3-VT), to explore treatment strategies and to prognostic characteristics, and to provide diagnostic and therapeutic references for TFE3-VT patients.
7. [Clinicopathological and prognostic differences between clear cell and non-clear cell renal cell carcinoma with venous tumor thrombus].
作者: B Guo.;M Lu.;G Wang.;H Zhang.;L Liu.;X Hou.;L Zhao.;X Tian.;S Zhang.
来源: Beijing Da Xue Xue Bao Yi Xue Ban. 2025年57卷4期644-649页
To compare the clinicopathological characteristics and prognostic outcomes between patients with clear cell renal cell carcinoma (ccRCC) and non-clear cell renal cell carcinoma (nccRCC) accompanied by venous tumor thrombus.
8. [High expression of ELFN1 is a prognostic biomarker and promotes proliferation and metastasis of colorectal cancer cells].
作者: Kang Wang.;Haibin Li.;Jing Yu.;Yuan Meng.;Hongli Zhang.
来源: Nan Fang Yi Ke Da Xue Xue Bao. 2025年45卷7期1543-1553页
To explore the correlation of ELFN1 expression level with prognosis of colorectal cancer and its regulatory role in colorectal cancer cell proliferation and metastasis.
9. [High PRELID1 expression promotes epithelial-mesenchymal transition in gastric cancer cells and is associated with poor prognosis].
作者: Xuan Wu.;Jiamin Fang.;Weiwei Han.;Lin Chen.;Jing Sun.;Qili Jin.
来源: Nan Fang Yi Ke Da Xue Xue Bao. 2025年45卷7期1535-1542页
To investigate the correlation of PRELID1 with gastric cancer (GC) progression, prognosis, and epithelial-mesenchymal transition (EMT) and the underlying mechanisms.
10. [Pirfenidone inhibits bladder cancer xenograft growth in mice by regulating regulatory T cells].
作者: Hongbo Zhang.;Mengyu Yan.;Jiandong Zhang.;Peiwang Sun.;Rui Wang.;Yuanyuan Guo.
来源: Nan Fang Yi Ke Da Xue Xue Bao. 2025年45卷7期1513-1518页
To investigate the inhibitory effect of pirfenidone (PFD) on growth of bladder cancer xenograft and its regulatory effect on Treg cells in tumor-bearing mice.
11. [LncRNA SNHG15 promotes proliferation, migration and invasion of lung adenocarcinoma cells by regulating COX6B1 through sponge adsorption of miR-30b-3p].
作者: Xiuying Gong.;Shunfu Hou.;Miaomiao Zhao.;Xiaona Wang.;Zhihan Zhang.;Qinghua Liu.;Chonggao Yin.;Hongli Li.
来源: Nan Fang Yi Ke Da Xue Xue Bao. 2025年45卷7期1498-1505页
To explore the molecular mechanism by which lncRNA SNHG15 regulates proliferation, invasion and migration of lung adenocarcinoma cells.
12. [Overexpression of multimerin-2 promotes cutaneous melanoma cell invasion and migration and is associated with poor prognosis].
作者: Jinlong Pang.;Xinli Zhao.;Zhen Zhang.;Haojie Wang.;Xingqi Zhou.;Yumei Yang.;Shanshan Li.;Xiaoqiang Chang.;Feng Li.;Xian Li.
来源: Nan Fang Yi Ke Da Xue Xue Bao. 2025年45卷7期1479-1489页
To investigate the inhibitory effect of multimerin-2 (MMRN2) overexpression on growth and metastasis of cutaneous melanoma cells.
13. [Therapeutic mechanism of hederagenin, an active component in Guizhi Fuling Pellets, against cervical cancer in nude mice].
作者: Yinfu Zhu.;Yiran Li.;Yi Wang.;Yinger Huang.;Kunxiang Gong.;Wenbo Hao.;Lingling Sun.
来源: Nan Fang Yi Ke Da Xue Xue Bao. 2025年45卷7期1423-1433页
To explore the therapeutic mechanism of Guizhi Fuling (GZFL) Pellets against cervical cancer.
14. [Shuangshu Decoction inhibits growth of gastric cancer cell xenografts by promoting cell ferroptosis via the P53/SLC7A11/GPX4 axis].
作者: Xinyuan Chen.;Chengting Wu.;Ruidi Li.;Xueqin Pan.;Yaodan Zhang.;Junyu Tao.;Caizhi Lin.
来源: Nan Fang Yi Ke Da Xue Xue Bao. 2025年45卷7期1363-1371页
To explore the mechanism of Shuangshu Decoction (SSD) for inhibiting growth of gastric cancer xenografts in nude mice.
15. [Interpretation of important issues of the secondary clinical practice guideline on management of primary malignant bone tumors by the Japanese Orthopaedic Association].
Primary malignant bone tumors are extremely rare. Osteosarcoma, chondrosarcoma, Ewing's sarcoma, and myeloma are the most common malignancy in bone. Osteosarcoma and Ewing's sarcoma are common in children and adolescents, and the tumors are high lethality due to the high rate of pulmonary metastasis. While chondrosarcoma, myeloma, and chordoma are more common in middle aged and elderly people. Japanese Orthopaedic Association (JOA) published the secondary clinical practice guideline on the management of primary malignant bone tumors. We put an emphasis on explanation some important issue of this guideline for help Chinese musculoskeletal tumor professionals in clinical practice.
16. [Research Progress and Challenges of Oligometastasis in Non-small Cell Lung Cancer].
Oligometastasis represents a transitional state between early localized disease and widespread metastasis, characterized by limited tumor burden and distinct tumor biological behavior. Due to the relatively restricted number of metastatic lesions and involved organs, aggressive systemic therapy combined with local consolidative therapy offers potential for cure. With rapid advancements in molecular targeted therapies and immunotherapy, comprehensive management of oligometastatic non-small cell lung cancer (NSCLC) has gained increasing attention. This review summarizes the definition of NSCLC oligometastasis, recent therapeutic progress, and existing challenges, aiming to provide insights for clinical diagnosis and treatment strategies.
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17. [Clinical Characteristics, MAML2 Gene Rearrangement and Prognosis of Pulmonary Mucoepidermoid Carcinoma].
作者: Jianrong Bai.;Meng Yan.;Lingchuan Guo.;Zhe Lei.;Weishuo Liu.;Zigui Zou.;Jiao Li.;Yushuang Zheng.
来源: Zhongguo Fei Ai Za Zhi. 2025年28卷6期441-449页
Primary pulmonary mucoepidermoid carcinoma (PMEC) is an exceedingly rare malignancy originating from bronchial submucosal glands, accounting for <0.2% of lung cancers. Histologically characterized by a triphasic composition of mucinous, epidermoid, and intermediate cells, PMEC is classified into low-grade (favorable prognosis) and high-grade (aggressive behavior) subtypes. This study aimed to investigate the clinicopathological characteristics and prognostic indicators of PMEC.
18. [Analysis of Efficacy and Safety of Neoadjuvant Immunochemotherapy in Patients with Stage IB-IIIB Non-small Cell Lung Cancer].
作者: Zihao Li.;Xin Wang.;Yulong Wang.;Zhuoer Cui.;Xin Wang.;Xiao Li.;Guanchao Jiang.;Xun Wang.
来源: Zhongguo Fei Ai Za Zhi. 2025年28卷6期415-426页
Neoadjuvant immunochemotherapy has emerged as an indispensable therapeutic modality for non-small cell lung cancer (NSCLC). However, its clinical application experience remains limited, and the associations between various clinical factors and treatment benefits remain undefined. This study aims to evaluate the efficacy and safety of neoadjuvant immunochemotherapy in patients with stage IB-IIIB NSCLC in a real-world setting, analyze survival outcomes among subgroups with diverse clinical characteristics, and identify potential clinical predictive factors for pathological response.
19. Application and mechanisms of targeting BRD4 in osteosarcoma.
作者: Ding Chen.;Jiaming Tian.;Yihe Dong.;Zi Li.;Jun Huang.
来源: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2025年50卷3期416-429页
Metastasis is the primary cause of death in osteosarcoma, and current clinical treatments remain limited. BRD4, a key epigenetic regulator, has shown therapeutic promise in various cancers through its inhibition. However, the mechanistic role of BRD4 in osteosarcoma remains poorly understood. This study aims to elucidate the molecular mechanisms by which BRD4 regulate osteosarcoma progression and to explore novel therapeutic strategies.
20. Expression of WNT10A in papillary thyroid carcinoma and its effect on cell proliferation, invasion, and metastasis.
作者: Li Yuan.;Ping Zhou.;Yongfeng Zhao.;Jiale Li.;Yan Zhang.;Wengang Liu.
来源: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2025年50卷3期402-415页
Lymph node metastasis in papillary thyroid cancer (PTC) is closely associated with tumor recurrence and patient survival. However, current technologies have limited sensitivity in detecting occult cervical lymph node metastases. Identifying accurate molecular markers for predicting PTC metastasis holds significant clinical value. This study aims to analyze WNT10A expression in PTC and its clinical significance, and to explore the role of WNT10A gene knockdown in PTC cell proliferation, invasion, and metastasis.
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