Multidrug resistance (MDR) is the main cause of chemotherapeutic failure in lung cancer, and vinorelbine (NVB) is one of the most efficient drugs that threaten non-small cell lung cancer (NSCLC). The current study aims to establish tumor xenografts and investigate the molecular mechanisms involved in the resistance of NVB in lung adenocarcinoma.

To observe the time-dapendcrt expression of TLR4 and TNF-α of N9 microglia exposured to normobaric hyperoxia after preconditioning with lipopolysaccharide in vitro and to explore the role of hyperoxia on the pro-flammation response of microglia and mechanism.

EPCs were cultured in high-glucose-medium to induce oxidative stress. Concentration of malonaldehyde (MDA) and nitrogen monoxidum (NO) in culture medium were measured. The function of EPCs and protein expression of GPx-1 and eNOS were determined. Antioxidant alpha lipoic acid (ALA) was used as an intervention factor to explore the mechanism by which glucose induces the damage of EPCs.

To study the effect of GABA transporter (GAT-1) on the analgesic action of oxysophoridine (OSR) in the central nervous system of mice.

To explore the effect of ketamine on adrenal pheochromocytoma (PC12) cell proliferation inhibition and induction of apoptosis and its mechanism.

The characteristics of the induction of laccase in Trametes gallica under different initial cultural pH, incubation time by different inducers were discussed, as well as the effects of temperature, pH and time on laccase degradation of six dyes and four organophosphors. The results showed that RB-bright blue, ABTS and o-toluidine affected the production of laccase at different levels, and ABTS was the best inductive agent in our test conditions, whose optimal initial pH and incubation time were 4.0 and 13 days, respectively. The appropriate reaction temperature of the laccase produced was 38 degrees C, and it got a good stability, for it could retain 78.6% of the enzyme activity after 20 min holding at 40 degrees C. Mediated by ABTS, the optimal temperature for laccase to degrade the six types of neutral dyes could be divided into two cases, that was 30 degrees C (neutral black, neutral bordeaux, neutral pink, methyl orange) and 60 degrees C (neutral dark yellow, cresol red), the optimal pH were 6.0 (neutral black), 2.0 (neutral bordeaux, neutral pink) and 4.0 (methyl orange, neutral dark yellow, cresol red), respectively, while the optimal times separately were 6 h (methyl orange, neutral dark yellow, cresol red), 12 h (neutral pink) and 24 h (neutral bordeaux). And using the same inductive agent, the best temperature for laccase to degrade dimethoate, chlorpyrifos, trichlorfon and parathion-pyridazine was 25 degrees C, the suitable time was 9 h, and the optimal pH was 10.0 for dimethoate, chlorpyrifos and parathion-pyridazine, and 8.0 for trichlorfon.

To investigate the expression of Toll-like receptor 4 (TLR4) in the liver tissue of rats with bile duct ligation (BDL)-induced hepatic fibrosis and evaluate the inhibitory effects of perindopril and losartan on TLR4 expression.

To study the effect of genistein on the expression of heme oxygenase-1 (HO-1) in rats with pulmonary arterial hypertension (PAH) induced by monocrotaline (MCT).

To observe the effects of Astragalus polysaccharides (APS) on the BG, insulin and C-peptide in serum, ultrastructure and Fas expression of pancreatic beta-cells in diabetes mellitus (DM) rats.

To study the effect of drug serum of prepared Radix Polygoni Multiflori on rat osteoblast (Ob) and its mechanism.

To explore the effect and mechanism of berberine on diabetic nephropathy in experimental rats.

To evaluate the effects of Bevacizumab on the tumor growth, proliferation and apoptosis of gastric cancer xenograft, and the impacts on the VEGF and Sp1 expression.

To investigate the role of ATP-binding cassette transporter G1 (ABCG1) in endothelial dysfunction induced by high glucose.

To investigate the effect of extract of ginkgo biloba leaf (EGb) during the formation of HBV-related hepatocellular carcinoma (HCC).

To investigate the mechanism of loss of human esophageal cancer-related gene 4 (ECRG4) expression in esophageal squamous cell carcinoma (ESCC.)

Utilizing a gene reporter technique to study the effects of Andrographitis Herba on human CXCR4 and CCR5 promoters.

To study the molecular mechanism of tetramethylpyrazine to induce human promyelocytic HL-60 leukemia cells differentiation.

To investigate the effect of interleukin-17 (IL-17) on the expression of monocyte chemoattractant protein-1(MCP-1) in the primary cultured cardiac myocytes.

To explore the effects of 1, 25(OH)(2);D(3); on parathyroid hormone (PTH) induced transdifferentiation and TGF-β(1); expression in cultured human renal tubular epithelial cells.

Taking the floral buds of 10 years old field-cultivated and 3 years old potted nectarine (Prunus persica var. nectarine cv. Shuguang) as test materials, and by the method of real-time quantitative PCR, this paper studied the expressions of the AQPs genes deltaTIP1 and PIP1; 1 during dormancy and dormancy-release (September 15, 2009-January 15, 2010) and the transcriptional levels of the genes under low temperature stress. Within the period of dormancy and dormancy-release, the transcriptional level of PIP1; 1 presented a persistent increasing trend, and the high level expression of PIP1; 1 in January could be related to the efflux of water through cytoplasma membrane and vacuolar membrane, which protected the bud cells from ice crystal injuries. The contents of soluble sugar, soluble protein, and proline in the bud cells all peaked in January, which prevented the excessive water loss from the cells. After 2 weeks of low temperature treatment, the PIP1; 1 had a high level expression, indicating that it was a cold-induced gene. The transcriptional level of deltaTIP1 fluctuated during dormancy, and increased significantly during dormancy-release, which might be induced by the dormancy-release signals in buds and the resumption of plant activity. After 2 weeks of low temperature treatment, the expression level of deltaTIP1 had no increase, indicating that deltaTIP1 was not a cold-induced gene.