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1. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Risk Score in Young Adults Predicts Coronary Artery and Abdominal Aorta Calcium in Middle Age: The CARDIA Study.
作者: Samuel S Gidding.;Jamal S Rana.;Christopher Prendergast.;Henry McGill.;J Jeffery Carr.;Kiang Liu.;Laura A Colangelo.;Catherine M Loria.;Joao Lima.;James G Terry.;Jared P Reis.;C Alex McMahan.
来源: Circulation. 2016年133卷2期139-46页
We explored whether, the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) coronary and abdominal risk scores measured at 18 to 30 years of age and changes in these scores would more strongly predict coronary artery calcium (CAC) and abdominal aortic calcium (AAC) assessed 25 years later, than scores measured 25 years later.
2. A Call to Reduce the Use of Bridging Anticoagulation.
作者: Adam J Rose.;Arthur L Allen.;Tracy Minichello.
来源: Circ Cardiovasc Qual Outcomes. 2016年9卷1期64-7页
Because of the recent publication of several important studies, there has been a major change in how we think about perioperative management of anticoagulation. Because of these changes, existing consensus guidelines are suddenly out of date and can no longer be used as is, particularly the 2012 American College of Chest Physicians Antithrombotic Guidelines, version 9. We estimate that well over 90% of patients receiving warfarin therapy should not receive bridging anticoagulation during periprocedural interruptions of therapy, except under unusual circumstances and with appropriate justification. Accumulating evidence also suggests that bridging is not indicated among patients receiving direct-acting oral anticoagulant therapy. The large number of patients potentially affected represents an important safety concern and requires an immediate change in practice.
3. Geriatric Conditions in Patients Undergoing Defibrillator Implantation for Prevention of Sudden Cardiac Death: Prevalence and Impact on Mortality.
作者: Ariel R Green.;Bruce Leff.;Yongfei Wang.;Erica S Spatz.;Frederick A Masoudi.;Pamela N Peterson.;Stacie L Daugherty.;Daniel D Matlock.
来源: Circ Cardiovasc Qual Outcomes. 2016年9卷1期23-30页
Geriatric conditions may influence outcomes among patients receiving implantable cardioverter-defibrillators (ICDs). We sought to determine the prevalence of frailty and dementia among older adults receiving primary prevention ICDs and to determine the impact of multimorbidity on mortality within 1 year of ICD implantation.
4. Prediction of All-Cause Mortality Based on the Direct Measurement of Intrathoracic Impedance.
作者: Michael R Zile.;Vinod Sharma.;James W Johnson.;Eduardo N Warman.;Catalin F Baicu.;Tom D Bennett.
来源: Circ Heart Fail. 2016年9卷1期e002543页
Intrathoracic impedance-derived OptiVol fluid index calculated using implanted devices has been shown to predict mortality; direct measurements of impedance have not been examined. We hypothesized that baseline measured impedance predicts all-cause mortality; changes in measured impedance result in a change in the predicted mortality; and the prognostic value of measured impedance is additive to the calculated OptiVol fluid index.
5. Mortality Associated With Heart Failure After Myocardial Infarction: A Contemporary Community Perspective.
作者: Yariv Gerber.;Susan A Weston.;Maurice Enriquez-Sarano.;Cecilia Berardi.;Alanna M Chamberlain.;Sheila M Manemann.;Ruoxiang Jiang.;Shannon M Dunlay.;Véronique L Roger.
来源: Circ Heart Fail. 2016年9卷1期e002460页
Contemporary data are lacking on the prognostic importance of heart failure (HF) after myocardial infarction (MI). We evaluated the prognostic impact of HF post MI according to preserved/reduced ejection fraction and the timing of its occurrence.
6. Cardiovascular Health Status and Incidence of Heart Failure in the Framingham Offspring Study.
作者: Matthew Nayor.;Danielle M Enserro.;Ramachandran S Vasan.;Vanessa Xanthakis.
来源: Circ Heart Fail. 2016年9卷1期e002416页
The American Heart Association Cardiovascular Health (CVH) score is inversely associated with cardiovascular disease, but its relations to cardiac remodeling traits and heart failure (HF) incidence have not been examined.
7. Influence of Titration of Neurohormonal Antagonists and Blood Pressure Reduction on Renal Function and Decongestion in Decompensated Heart Failure.
作者: Alexander J Kula.;Jennifer S Hanberg.;F Perry Wilson.;Meredith A Brisco.;Lavanya Bellumkonda.;Daniel Jacoby.;Steven G Coca.;Chirag R Parikh.;W H Wilson Tang.;Jeffrey M Testani.
来源: Circ Heart Fail. 2016年9卷1期e002333页
Reduction in systolic blood pressure (SBP reduction) during the treatment of acute decompensated heart failure is strongly and independently associated with worsening renal function. Our objective was to determine whether SBP reduction or titration of oral neurohormonal antagonists during acute decompensated heart failure treatment negatively influences diuresis and decongestion.
8. Is Myocarditis an Independent Risk Factor for Post-Transplant Mortality in Pediatric Heart Transplant Recipients?
作者: Jessica C Garbern.;Kimberlee Gauvreau.;Elizabeth D Blume.;Tajinder P Singh.
来源: Circ Heart Fail. 2016年9卷1期e002328页
Previous studies suggest that children with myocarditis who receive heart transplantation (HT) may be at higher risk of post-transplant mortality compared with children who are transplanted for idiopathic dilated cardiomyopathy. We hypothesized that these differences are because of more severe heart failure at HT in children with myocarditis.
9. Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure.
作者: Chelsea L Organ.;Hiroyuki Otsuka.;Shashi Bhushan.;Zeneng Wang.;Jessica Bradley.;Rishi Trivedi.;David J Polhemus.;W H Wilson Tang.;Yuping Wu.;Stanley L Hazen.;David J Lefer.
来源: Circ Heart Fail. 2016年9卷1期e002314页
Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients, is both elevated in the circulation of patients having heart failure and heralds worse overall prognosis. In animal studies, dietary choline or TMAO significantly accelerates atherosclerotic lesion development in ApoE-deficient mice, and reduction in TMAO levels inhibits atherosclerosis development in the low-density lipoprotein receptor knockout mouse.
10. Sympathoexcitation in Rats With Chronic Heart Failure Depends on Homeobox D10 and MicroRNA-7b Inhibiting GABBR1 Translation in Paraventricular Nucleus.
作者: Renjun Wang.;Qian Huang.;Rui Zhou.;Zengxiang Dong.;Yunfeng Qi.;Hua Li.;Xiaowei Wei.;Hui Wu.;Huiping Wang.;Christopher S Wilcox.;Michael Hultström.;Xiaofu Zhou.;En Yin Lai.
来源: Circ Heart Fail. 2016年9卷1期e002261页
Chronic heart failure (CHF) increases sympathoexcitation through angiotensin II (ANG II) receptors (AT1R) in the paraventricular nucleus (PVN). Recent publications indicate both γ-aminobutyric acid B-type receptor 1 (GABBR1) and microRNA-7b (miR-7b) are expressed in the PVN. We hypothesized that ANG II regulates sympathoexcitation through homeobox D10 (HoxD10), which regulates miR-7b in other tissues.
11. Psychosocial Factors and Risk of Incident Heart Failure: The Multi-Ethnic Study of Atherosclerosis.
作者: Rachel P Ogilvie.;Susan A Everson-Rose.;W T Longstreth.;Carlos J Rodriguez.;Ana V Diez-Roux.;Pamela L Lutsey.
来源: Circ Heart Fail. 2016年9卷1期e002243页
Heart failure (HF) is a major source of morbidity and mortality in the United States. Psychosocial factors have frequently been studied as risk factors for coronary heart disease but not for HF.
12. Elevated Soluble Fms-Like Tyrosine Kinase-1 and Placental-Like Growth Factor Levels Are Associated With Development and Mortality Risk in Heart Failure.
作者: Muhammad Hammadah.;Vasiliki V Georgiopoulou.;Andreas P Kalogeropoulos.;Malory Weber.;Xi Wang.;Michael A Samara.;Yuping Wu.;Javed Butler.;W H Wilson Tang.
来源: Circ Heart Fail. 2016年9卷1期e002115页
Vascular endothelial dysfunction may play an important role in the progression of heart failure (HF). We hypothesize that elevated levels of vascular markers, placental-like growth factor, and soluble Fms-like tyrosine kinase-1 (sFlt-1) are associated with adverse outcomes in patients with HF. We also assessed possible triggers of sFlt-1 elevation in animal HF models.
13. Quality of Life With Ivabradine in Patients With Angina Pectoris: The Study Assessing the Morbidity-Mortality Benefits of the If Inhibitor Ivabradine in Patients With Coronary Artery Disease Quality of Life Substudy.
作者: Michal Tendera.;Olivier Chassany.;Roberto Ferrari.;Ian Ford.;Philippe Gabriel Steg.;Jean-Claude Tardif.;Kim Fox.; .
来源: Circ Cardiovasc Qual Outcomes. 2016年9卷1期31-8页
To explore the effect of ivabradine on angina-related quality of life (QoL) in patients participating in the Study Assessing the Morbidity-Mortality Benefits of the If Inhibitor Ivabradine in Patients with Coronary Artery Disease (SIGNIFY) QoL substudy.
14. Long-Term Nationwide Follow-Up Study of Simple Congenital Heart Disease Diagnosed in Otherwise Healthy Children.
作者: Jørgen Videbæk.;Henning Bækgaard Laursen.;Morten Olsen.;Dan Eik Høfsten.;Søren Paaske Johnsen.
来源: Circulation. 2016年133卷5期474-83页
Systematic follow-up is currently not recommended for patients with simple congenital heart disease; however, only a few data exist on the long-term prognosis of simple congenital heart disease.
15. Unplanned Inpatient and Observation Rehospitalizations After Acute Myocardial Infarction: Insights From the Treatment With Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome (TRANSLATE-ACS) Study.
作者: Connie N Hess.;Tracy Y Wang.;Lisa A McCoy.;John C Messenger.;Mark B Effron.;Marjorie E Zettler.;Timothy D Henry.;Eric D Peterson.;Gregg C Fonarow.
来源: Circulation. 2016年133卷5期493-501页
Previous studies examining early readmission after acute myocardial infarction have focused exclusively on inpatient readmissions. However, from a patient's perspective, any unplanned inpatient or observation rehospitalization after acute myocardial infarction represents a significant event; these unplanned rehospitalizations have not been well characterized.
16. Risks of Death and Stroke in Patients Undergoing Hemodialysis With New-Onset Atrial Fibrillation: A Competing-Risk Analysis of a Nationwide Cohort.
作者: Chia-Jen Shih.;Shuo-Ming Ou.;Pei-Wen Chao.;Shu-Chen Kuo.;Yi-Jung Lee.;Chih-Yu Yang.;Der-Cherng Tarng.;Chih-Ching Lin.;Po-Hsun Huang.;Szu-Yuan Li.;Yung-Tai Chen.
来源: Circulation. 2016年133卷3期265-72页
Whether oral anticoagulant use should be considered in patients undergoing hemodialysis with atrial fibrillation (AF) remains controversial because of the uncertainty regarding risk-benefit assessments. The purpose of this study was to investigate the risk of ischemic stroke in patients undergoing hemodialysis with new-onset AF, in comparison with those without arrhythmia.
17. Novel 6p21.3 Risk Haplotype Predisposes to Acute Coronary Syndrome.
作者: Juha Sinisalo.;Efthymia Vlachopoulou.;Marja Marchesani.;Johanna Nokelainen.;Mikko I Mäyränpää.;Jani Lappalainen.;Riitta Paakkanen.;Annika Wennerström.;Krista Salli.;Heikki J Niemi.;Satu Männistö.;Perttu Salo.;Juhani Junttila.;Markku Eskola.;Kjell Nikus.;T Petteri Arstila.;Markus Perola.;Heikki Huikuri.;Pekka J Karhunen.;Petri T Kovanen.;Aarno Palotie.;Aki S Havulinna.;Carla Lluis-Ganella.;Jaume Marrugat.;Roberto Elosua.;Veikko Salomaa.;Markku S Nieminen.;Marja-Liisa Lokki.
来源: Circ Cardiovasc Genet. 2016年9卷1期55-63页
The HLA-DRB1*01 allele of the human leukocyte antigen has been associated with acute coronary syndrome. Genome-wide association studies have revealed associations with human leukocyte antigen and non-human leukocyte antigen genes of 3 major histocompatibility complex gene classes but not at allelic level.
18. Interaction of Hereditary Thrombophilia and Traditional Cardiovascular Risk Factors on the Risk of Arterial Thromboembolism: Pooled Analysis of Four Family Cohort Studies.
作者: Bakhtawar K Mahmoodi.;Nic J G M Veeger.;Saskia Middeldorp.;Willem M Lijfering.;Jan-Leendert P Brouwer.;Jur Ten Berg.;Karly Hamulyák.;Karina Meijer.
来源: Circ Cardiovasc Genet. 2016年9卷1期79-85页
Hereditary thrombophilia is associated with a slightly increased risk of arterial thromboembolism (ATE). Whether hereditary thrombophilia interacts with traditional cardiovascular risk factors on the risk of ATE has yet to be established.
19. Polypharmacy and the Efficacy and Safety of Rivaroxaban Versus Warfarin in the Prevention of Stroke in Patients With Nonvalvular Atrial Fibrillation.
作者: Jonathan P Piccini.;Anne S Hellkamp.;Jeffrey B Washam.;Richard C Becker.;Günter Breithardt.;Scott D Berkowitz.;Jonathan L Halperin.;Graeme J Hankey.;Werner Hacke.;Kenneth W Mahaffey.;Christopher C Nessel.;Daniel E Singer.;Keith A A Fox.;Manesh R Patel.
来源: Circulation. 2016年133卷4期352-60页
Patients with atrial fibrillation (AF) often take multiple medications.
20. Novel Biomarker of Oxidative Stress Is Associated With Risk of Death in Patients With Coronary Artery Disease.
作者: Riyaz S Patel.;Nima Ghasemzadeh.;Danny J Eapen.;Salman Sher.;Shawn Arshad.;Yi-an Ko.;Emir Veledar.;Habib Samady.;A Maziar Zafari.;Laurence Sperling.;Viola Vaccarino.;Dean P Jones.;Arshed A Quyyumi.
来源: Circulation. 2016年133卷4期361-9页
Free radical scavengers have failed to improve patient outcomes, promoting the concept that clinically important oxidative stress may be mediated by alternative mechanisms. We sought to examine the association of emerging aminothiol markers of nonfree radical mediated oxidative stress with clinical outcomes.
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