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5. Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy.
作者: Christine E Brown.;Darya Alizadeh.;Renate Starr.;Lihong Weng.;Jamie R Wagner.;Araceli Naranjo.;Julie R Ostberg.;M Suzette Blanchard.;Julie Kilpatrick.;Jennifer Simpson.;Anita Kurien.;Saul J Priceman.;Xiuli Wang.;Todd L Harshbarger.;Massimo D'Apuzzo.;Julie A Ressler.;Michael C Jensen.;Michael E Barish.;Mike Chen.;Jana Portnow.;Stephen J Forman.;Behnam Badie.
来源: N Engl J Med. 2016年375卷26期2561-9页
A patient with recurrent multifocal glioblastoma received chimeric antigen receptor (CAR)-engineered T cells targeting the tumor-associated antigen interleukin-13 receptor alpha 2 (IL13Rα2). Multiple infusions of CAR T cells were administered over 220 days through two intracranial delivery routes - infusions into the resected tumor cavity followed by infusions into the ventricular system. Intracranial infusions of IL13Rα2-targeted CAR T cells were not associated with any toxic effects of grade 3 or higher. After CAR T-cell treatment, regression of all intracranial and spinal tumors was observed, along with corresponding increases in levels of cytokines and immune cells in the cerebrospinal fluid. This clinical response continued for 7.5 months after the initiation of CAR T-cell therapy. (Funded by Gateway for Cancer Research and others; ClinicalTrials.gov number, NCT02208362 .).
6. Fish Oil-Derived Fatty Acids in Pregnancy and Wheeze and Asthma in Offspring.
作者: Hans Bisgaard.;Jakob Stokholm.;Bo L Chawes.;Nadja H Vissing.;Elin Bjarnadóttir.;Ann-Marie M Schoos.;Helene M Wolsk.;Tine M Pedersen.;Rebecca K Vinding.;Sunna Thorsteinsdóttir.;Nilofar V Følsgaard.;Nadia R Fink.;Jonathan Thorsen.;Anders G Pedersen.;Johannes Waage.;Morten A Rasmussen.;Ken D Stark.;Sjurdur F Olsen.;Klaus Bønnelykke.
来源: N Engl J Med. 2016年375卷26期2530-9页
Reduced intake of n-3 long-chain polyunsaturated fatty acids (LCPUFAs) may be a contributing factor to the increasing prevalence of wheezing disorders. We assessed the effect of supplementation with n-3 LCPUFAs in pregnant women on the risk of persistent wheeze and asthma in their offspring.
8. Activity of Selumetinib in Neurofibromatosis Type 1-Related Plexiform Neurofibromas.
作者: Eva Dombi.;Andrea Baldwin.;Leigh J Marcus.;Michael J Fisher.;Brian Weiss.;AeRang Kim.;Patricia Whitcomb.;Staci Martin.;Lindsey E Aschbacher-Smith.;Tilat A Rizvi.;Jianqiang Wu.;Rachel Ershler.;Pamela Wolters.;Janet Therrien.;John Glod.;Jean B Belasco.;Elizabeth Schorry.;Alessandra Brofferio.;Amy J Starosta.;Andrea Gillespie.;Austin L Doyle.;Nancy Ratner.;Brigitte C Widemann.
来源: N Engl J Med. 2016年375卷26期2550-2560页
Effective medical therapies are lacking for the treatment of neurofibromatosis type 1-related plexiform neurofibromas, which are characterized by elevated RAS-mitogen-activated protein kinase (MAPK) signaling.
12. Hypothermia for Neuroprotection in Convulsive Status Epilepticus.
作者: Stephane Legriel.;Virginie Lemiale.;Maleka Schenck.;Jonathan Chelly.;Virginie Laurent.;Fabrice Daviaud.;Mohamed Srairi.;Aicha Hamdi.;Guillaume Geri.;Thomas Rossignol.;Julia Hilly-Ginoux.;Julie Boisramé-Helms.;Benjamin Louart.;Isabelle Malissin.;Nicolas Mongardon.;Benjamin Planquette.;Marina Thirion.;Sybille Merceron.;Emmanuel Canet.;Fernando Pico.;Yves-Roger Tran-Dinh.;Jean-Pierre Bedos.;Elie Azoulay.;Matthieu Resche-Rigon.;Alain Cariou.; .
来源: N Engl J Med. 2016年375卷25期2457-2467页
Convulsive status epilepticus often results in permanent neurologic impairment. We evaluated the effect of induced hypothermia on neurologic outcomes in patients with convulsive status epilepticus.
13. Shortened Antimicrobial Treatment for Acute Otitis Media in Young Children.
作者: Alejandro Hoberman.;Jack L Paradise.;Howard E Rockette.;Diana H Kearney.;Sonika Bhatnagar.;Timothy R Shope.;Judith M Martin.;Marcia Kurs-Lasky.;Susan J Copelli.;D Kathleen Colborn.;Stan L Block.;John J Labella.;Thomas G Lynch.;Norman L Cohen.;MaryAnn Haralam.;Marcia A Pope.;Jennifer P Nagg.;Michael D Green.;Nader Shaikh.
来源: N Engl J Med. 2016年375卷25期2446-2456页
Limiting the duration of antimicrobial treatment constitutes a potential strategy to reduce the risk of antimicrobial resistance among children with acute otitis media.
15. Interim Buprenorphine vs. Waiting List for Opioid Dependence.
作者: Stacey C Sigmon.;Taylor A Ochalek.;Andrew C Meyer.;Bryce Hruska.;Sarah H Heil.;Gary J Badger.;Gail Rose.;John R Brooklyn.;Robert P Schwartz.;Brent A Moore.;Stephen T Higgins.
来源: N Engl J Med. 2016年375卷25期2504-2505页 20. Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis.
作者: Xavier Montalban.;Stephen L Hauser.;Ludwig Kappos.;Douglas L Arnold.;Amit Bar-Or.;Giancarlo Comi.;Jérôme de Seze.;Gavin Giovannoni.;Hans-Peter Hartung.;Bernhard Hemmer.;Fred Lublin.;Kottil W Rammohan.;Krzysztof Selmaj.;Anthony Traboulsee.;Annette Sauter.;Donna Masterman.;Paulo Fontoura.;Shibeshih Belachew.;Hideki Garren.;Nicole Mairon.;Peter Chin.;Jerry S Wolinsky.; .
来源: N Engl J Med. 2017年376卷3期209-220页
An evolving understanding of the immunopathogenesis of multiple sclerosis suggests that depleting B cells could be useful for treatment. We studied ocrelizumab, a humanized monoclonal antibody that selectively depletes CD20-expressing B cells, in the primary progressive form of the disease.
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