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1. Efficacy of pancreatic enzyme replacement therapy in chronic pancreatitis: systematic review and meta-analysis.
作者: Daniel de la Iglesia-García.;Wei Huang.;Peter Szatmary.;Iria Baston-Rey.;Jaime Gonzalez-Lopez.;Guillermo Prada-Ramallal.;Rajarshi Mukherjee.;Quentin M Nunes.;J Enrique Domínguez-Muñoz.;Robert Sutton.; .
来源: Gut. 2017年66卷8期1354-1355页
The benefits of pancreatic enzyme replacement therapy (PERT) in chronic pancreatitis (CP) are inadequately defined. We have undertaken a systematic review and meta-analysis of randomised controlled trials of PERT to determine the efficacy of PERT in exocrine pancreatic insufficiency (EPI) from CP.
2. Systematic review of bariatric surgery liver biopsies clarifies the natural history of liver disease in patients with severe obesity.
作者: Pierre Bedossa.;Joan Tordjman.;Judith Aron-Wisnewsky.;Christine Poitou.;Jean-Michel Oppert.;Adriana Torcivia.;Jean-Luc Bouillot.;Valerie Paradis.;Vlad Ratziu.;Karine Clément.
来源: Gut. 2017年66卷9期1688-1696页
Non-alcoholic fatty liver disease (NAFLD) is a frequent complication of morbid obesity, but its severity varies greatly and thus there is a strong need to better define its natural history in these patients.
3. Recent advances in clinical practice: a systematic review of isolated colonic Crohn's disease: the third IBD?
The genetics of isolated colonic Crohn's disease place it approximately midway between Crohn's disease with small intestinal involvement and UC, making a case for considering it as a separate condition. We have therefore systematically reviewed its epidemiology, pathophysiology and treatment. Key findings include a higher incidence in females (65%) and older average age at presentation than Crohn's disease at other sites, a mucosa-associated microbiota between that found in ileal Crohn's disease and UC, no response to mesalazine, but possibly better response to antitumour necrosis factor than Crohn's disease at other sites. Diagnostic distinction from UC is often difficult and also needs to exclude other conditions including ischaemic colitis, segmental colitis associated with diverticular disease and tuberculosis. Future studies, particularly clinical trials, but also historical cohorts, should assess isolated colonic Crohn's disease separately.
4. Disease activity indices in coeliac disease: systematic review and recommendations for clinical trials.
作者: Pieter Hindryckx.;Barrett G Levesque.;Tom Holvoet.;Serina Durand.;Ceen-Ming Tang.;Claire Parker.;Reena Khanna.;Lisa M Shackelton.;Geert D'Haens.;William J Sandborn.;Brian G Feagan.;Benjamin Lebwohl.;Daniel A Leffler.;Vipul Jairath.
来源: Gut. 2018年67卷1期61-69页
Although several pharmacological agents have emerged as potential adjunctive therapies to a gluten-free diet for coeliac disease, there is currently no widely accepted measure of disease activity used in clinical trials. We conducted a systematic review of coeliac disease activity indices to evaluate their operating properties and potential as outcome measures in registration trials.
5. First-line Helicobacter pylori eradication therapies in countries with high and low clarithromycin resistance: a systematic review and network meta-analysis.
作者: Yee Hui Yeo.;Sz-Iuan Shiu.;Hsiu J Ho.;Biyao Zou.;Jaw-Town Lin.;Ming-Shiang Wu.;Jyh-Ming Liou.;Chun-Ying Wu.; .
来源: Gut. 2018年67卷1期20-27页
To determine the optimal regimen of different first-line Helicobacter pylori eradication therapies according to the clarithromycin resistance rate.
6. Comparison of efficacy of pharmacological treatments for chronic idiopathic constipation: a systematic review and network meta-analysis.
作者: Alfred D Nelson.;Michael Camilleri.;Sakkarin Chirapongsathorn.;Priya Vijayvargiya.;Nelson Valentin.;Andrea Shin.;Patricia J Erwin.;Zhen Wang.;M Hassan Murad.
来源: Gut. 2017年66卷9期1611-1622页
To compare efficacy of pharmacotherapies for chronic idiopathic constipation (CIC) based on comparisons to placebo using Bayesian network meta-analysis.
7. The prognostic value of TP53 mutations in oesophageal adenocarcinoma: a systematic review and meta-analysis.
作者: Oliver M Fisher.;Sarah J Lord.;Dan Falkenback.;Nicholas J Clemons.;Guy D Eslick.;Reginald V Lord.
来源: Gut. 2017年66卷3期399-410页
To clarify the prognostic role of tumour protein 53 (TP53) mutations in patients with oesophageal adenocarcinoma (OAC) as there is a need for biomarkers that assist in guiding management for patients with OAC.
8. Efficacy of psychotropic drugs in functional dyspepsia: systematic review and meta-analysis.
作者: Alexander C Ford.;Pavit Luthra.;Jan Tack.;Guy E Boeckxstaens.;Paul Moayyedi.;Nicholas J Talley.
来源: Gut. 2017年66卷3期411-420页
Functional dyspepsia (FD) is a chronic gastroduodenal disorder. Individuals with FD demonstrate visceral hypersensitivity, abnormal central pain processing, and low mood, but it is unclear whether psychotropic drugs are an effective treatment for the condition. We performed a systematic review and meta-analysis of randomised controlled trials (RCTs).
9. Dual role of Helicobacter and Campylobacter species in IBD: a systematic review and meta-analysis.
作者: Natalia Castaño-Rodríguez.;Nadeem O Kaakoush.;Way Seah Lee.;Hazel M Mitchell.
来源: Gut. 2017年66卷2期235-249页
To conduct a comprehensive global systematic review and meta-analysis on the association between Helicobacter pylori infection and IBD. As bacterial antigen cross-reactivity has been postulated to be involved in this association, published data on enterohepatic Helicobacter spp (EHS) and Campylobacter spp and IBD was also analysed.
10. Biomarkers for bile acid diarrhoea in functional bowel disorder with diarrhoea: a systematic review and meta-analysis.
作者: Nelson Valentin.;Michael Camilleri.;Osama Altayar.;Priya Vijayvargiya.;Andres Acosta.;Alfred D Nelson.;M Hassan Murad.
来源: Gut. 2016年65卷12期1951-1959页
There is no universally available laboratory test to diagnose bile acid diarrhoea (BAD).
11. Genetic variation and gastric cancer risk: a field synopsis and meta-analysis.
Data on genetic susceptibility to sporadic gastric carcinoma have been published at a growing pace, but to date no comprehensive overview and quantitative summary has been available.
12. Efficacy and safety of endoscopic resection of large colorectal polyps: a systematic review and meta-analysis.
作者: C Hassan.;A Repici.;P Sharma.;L Correale.;A Zullo.;M Bretthauer.;C Senore.;C Spada.;Cristina Bellisario.;P Bhandari.;D K Rex.
来源: Gut. 2016年65卷5期806-20页
To assess the efficacy and safety of endoscopic resection of large colorectal polyps.
13. Training and competence assessment in GI endoscopy: a systematic review.
作者: Vivian E Ekkelenkamp.;Arjun D Koch.;Robert A de Man.;Ernst J Kuipers.
来源: Gut. 2016年65卷4期607-15页
Training procedural skills in GI endoscopy once focused on threshold numbers. As threshold numbers poorly reflect individual competence, the focus gradually shifts towards a more individual approach. Tools to assess and document individual learning progress are being developed and incorporated in dedicated training curricula. However, there is a lack of consensus and training guidelines differ worldwide, which reflects uncertainties on optimal set-up of a training programme.
14. Global prevalence of, and risk factors for, uninvestigated dyspepsia: a meta-analysis.
Many cross-sectional surveys have reported the prevalence of uninvestigated dyspepsia, but there has been no recent systematic review of data from all studies to determine its global prevalence and risk factors.
15. Systematic review: Monotherapy with antitumour necrosis factor α agents versus combination therapy with an immunosuppressive for IBD.
作者: Parambir S Dulai.;Corey A Siegel.;Jean-Frederic Colombel.;William J Sandborn.;Laurent Peyrin-Biroulet.
来源: Gut. 2014年63卷12期1843-53页 16. A global consensus on the classification, diagnosis and multidisciplinary treatment of perianal fistulising Crohn's disease.
作者: Krisztina B Gecse.;Willem Bemelman.;Michael A Kamm.;Jaap Stoker.;Reena Khanna.;Siew C Ng.;Julián Panés.;Gert van Assche.;Zhanju Liu.;Ailsa Hart.;Barrett G Levesque.;Geert D'Haens.; .; .
来源: Gut. 2014年63卷9期1381-92页
To develop a consensus on the classification, diagnosis and multidisciplinary treatment of perianal fistulising Crohn's disease (pCD), based on best available evidence.
17. Hospital and surgeon volume in relation to long-term survival after oesophagectomy: systematic review and meta-analysis.
Centralisation of healthcare, especially for advanced cancer surgery, has been a matter of debate. Clear short-term mortality benefits have been described for oesophageal cancer surgery conducted at high-volume hospitals and by high-volume surgeons.
18. Acid-suppressive medications and risk of oesophageal adenocarcinoma in patients with Barrett's oesophagus: a systematic review and meta-analysis.
作者: Siddharth Singh.;Sushil Kumar Garg.;Preet Paul Singh.;Prasad G Iyer.;Hashem B El-Serag.
来源: Gut. 2014年63卷8期1229-37页
Acid-suppressive medications, particularly proton pump inhibitors (PPIs), may decrease the risk of oesophageal adenocarcinoma (OAC) in patients with Barrett's oesophagus (BO). We performed a systematic review with meta-analysis of studies evaluating the association between acid-suppressive medications (PPIs and histamine receptor antagonists (H2RAs)) and risk of OAC or high-grade dysplasia (BO-HGD) in patients with BO.
19. The burden of stomach cancer in indigenous populations: a systematic review and global assessment.
作者: Melina Arnold.;Suzanne P Moore.;Sven Hassler.;Lis Ellison-Loschmann.;David Forman.;Freddie Bray.
来源: Gut. 2014年63卷1期64-71页
Stomach cancer is a leading cause of cancer death, especially in developing countries. Incidence has been associated with poverty and is also reported to disproportionately affect indigenous peoples, many of whom live in poor socioeconomic circumstances and experience lower standards of health. In this comprehensive assessment, we explore the burden of stomach cancer among indigenous peoples globally.
20. Newly diagnosed diabetes mellitus after acute pancreatitis: a systematic review and meta-analysis.
作者: Stephanie L M Das.;Primal P Singh.;Anthony R J Phillips.;Rinki Murphy.;John A Windsor.;Maxim S Petrov.
来源: Gut. 2014年63卷5期818-31页
Diabetes mellitus (DM) is common in the general population and it poses a heavy burden to society in the form of long-term disability, healthcare use and costs. The pancreas is a key player in glucose homeostasis, but the occurrence of newly diagnosed DM after acute pancreatitis (AP), the most frequent disease of the pancreas, has never been assessed systematically. The aim of this study was to conduct a systematic literature review to determine the prevalence and time course of DM and related conditions after the first attack of AP as well as the impact of covariates.
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