当前位置: 首页 >> 检索结果
1. Improved Cough and Cough-Specific Quality of Life in Patients Treated for Scleroderma-Related Interstitial Lung Disease: Results of Scleroderma Lung Study II.
作者: Donald P Tashkin.;Elizabeth R Volkmann.;Chi-Hong Tseng.;Michael D Roth.;Dinesh Khanna.;Daniel E Furst.;Philip J Clements.;Arthur Theodore.;Suzanne Kafaja.;Grace Hyun Kim.;Jonathan Goldin.;Edgar Ariolla.;Robert M Elashoff.
来源: Chest. 2017年151卷4期813-820页
Cough is a common symptom of scleroderma-related interstitial lung disease (SSc-ILD), but its relationship to other characteristics of SSc-ILD, impact on cough-specific quality of life (QoL), and response to therapy for SSc-ILD have not been well studied.
2. Postoperative Oxygen Therapy in Patients With OSA: A Randomized Controlled Trial.
作者: Pu Liao.;Jean Wong.;Mandeep Singh.;David T Wong.;Sazzadul Islam.;Maged Andrawes.;Colin M Shapiro.;David P White.;Frances Chung.
来源: Chest. 2017年151卷3期597-611页
Surgical patients with OSA are at increased risk for perioperative complications. Postoperative supplemental oxygen is commonly used, but it may contribute to respiratory depression in patients with OSA receiving opioids. The objective of the study is to investigate the effect of postoperative supplemental oxygen on arterial oxygen saturation (Sao2), sleep respiratory events, and CO2 level in patients with untreated OSA.
3. Short-term Effects of Supplemental Oxygen on 6-Min Walk Test Outcomes in Patients With COPD: A Randomized, Placebo-Controlled, Single-blind, Crossover Trial.
作者: Inga Jarosch.;Rainer Gloeckl.;Eva Damm.;Anna-Lena Schwedhelm.;David Buhrow.;Andreas Jerrentrup.;Martijn A Spruit.;Klaus Kenn.
来源: Chest. 2017年151卷4期795-803页
The acute effect of supplemental oxygen during exercise has been shown to differ largely among patients with COPD. It is unknown what factors influence oxygen response.
4. Efficacy and Safety of Glycopyrrolate/Formoterol Metered Dose Inhaler Formulated Using Co-Suspension Delivery Technology in Patients With COPD.
作者: Fernando J Martinez.;Klaus F Rabe.;Gary T Ferguson.;Leonardo M Fabbri.;Stephen Rennard.;Gregory J Feldman.;Sanjay Sethi.;Selwyn Spangenthal.;Gregory M Gottschlich.;Roberto Rodriguez-Roisin.;Samir Arora.;Thomas M Siler.;Shahid Siddiqui.;Patrick Darken.;Tracy Fischer.;Andrea Maes.;Michael Golden.;Chad Orevillo.;Colin Reisner.
来源: Chest. 2017年151卷2期340-357页
Long-acting muscarinic antagonist (LAMA)/long-acting β2-agonist (LABA) combinations are a treatment option for patients with COPD who continue to have symptoms despite treatment with a LAMA or a LABA alone. The Efficacy and Safety of PT003, PT005, and PT001 in Subjects with Moderate-to-Very Severe COPD (PINNACLE-1) (NCT01854645) and the Multi-Center Study to Assess the Efficacy and Safety of PT003, PT005, and PT001 in Subjects with Moderate-to-Very Severe COPD (PINNACLE-2) (NCT01854658) trials investigated the efficacy and safety of a novel glycopyrrolate [GP]/formoterol [FF] 18/9.6-μg (GFF) metered dose inhaler (MDI) formulated using the Co-Suspension Delivery Technology in patients with moderate-to-very severe COPD.
5. A Randomized Trial of the Amikacin Fosfomycin Inhalation System for the Adjunctive Therapy of Gram-Negative Ventilator-Associated Pneumonia: IASIS Trial.
作者: Marin H Kollef.;Jean-Damien Ricard.;Damien Roux.;Bruno Francois.;Eleni Ischaki.;Zsolt Rozgonyi.;Thierry Boulain.;Zsolt Ivanyi.;Gál János.;Denis Garot.;Firas Koura.;Epaminondas Zakynthinos.;George Dimopoulos.;Antonio Torres.;Wayne Danker.;A Bruce Montgomery.
来源: Chest. 2017年151卷6期1239-1246页
Clinical failures in ventilator-associated pneumonia (VAP) caused by gram-negative bacteria are common and associated with substantial morbidity, mortality, and resource utilization.
6. Efficacy of Clarithromycin-Naproxen-Oseltamivir Combination in the Treatment of Patients Hospitalized for Influenza A(H3N2) Infection: An Open-label Randomized, Controlled, Phase IIb/III Trial.
作者: Ivan F N Hung.;Kelvin K W To.;Jasper F W Chan.;Vincent C C Cheng.;Kevin S H Liu.;Anthony Tam.;Tuen-Ching Chan.;Anna Jinxia Zhang.;Patrick Li.;Tin-Lun Wong.;Ricky Zhang.;Michael K S Cheung.;William Leung.;Johnson Y N Lau.;Manson Fok.;Honglin Chen.;Kwok-Hung Chan.;Kwok-Yung Yuen.
来源: Chest. 2017年151卷5期1069-1080页
Influenza causes excessive hospitalizations and deaths. The study assessed the efficacy and safety of a clarithromycin-naproxen-oseltamivir combination for treatment of serious influenza.
7. Stylet Use Does Not Improve Diagnostic Outcomes in Endobronchial Ultrasonographic Transbronchial Needle Aspiration: A Randomized Clinical Trial.
作者: Eric L Scholten.;Roy Semaan.;Peter Illei.;Christopher Mallow.;Sixto Arias.;David Feller-Kopman.;Karen Oakjones-Burgess.;Bernice Frimpong.;Ricardo O Amador.;Hans Lee.;Lonny Yarmus.
来源: Chest. 2017年151卷3期636-642页
Endobronchial ultrasonographically guided transbronchial needle aspiration (EBUS-TBNA) of thoracic structures is a commonly performed tissue sampling technique. The use of an inner-stylet in the EBUS needle has never been rigorously evaluated and may be unnecessary.
8. Macitentan Improves Health-Related Quality of Life for Patients With Pulmonary Arterial Hypertension: Results From the Randomized Controlled SERAPHIN Trial.
作者: Sanjay Mehta.;Bhagavatula Kutumba Srinivasa Sastry.;Rogério Souza.;Adam Torbicki.;Hossein-Ardeschir Ghofrani.;Richard N Channick.;Marion Delcroix.;Tomás Pulido.;Gérald Simonneau.;John Wlodarczyk.;Lewis J Rubin.;Pavel Jansa.;Elke Hunsche.;Nazzareno Galiè.;Loïc Perchenet.;Olivier Sitbon.
来源: Chest. 2017年151卷1期106-118页
Pulmonary arterial hypertension (PAH) leads to reduced health-related quality of life (HRQoL). The objectives of this analysis were to evaluate the effect of macitentan on HRQoL in patients with PAH in the Study with an Endothelin Receptor Antagonist in Pulmonary Arterial Hypertension to Improve Clinical Outcome (SERAPHIN) study. The association between baseline HRQoL and long-term outcomes was also investigated.
9. The COPD Assessment Test: Can It Discriminate Across COPD Subpopulations?
作者: Nisha Gupta.;Lancelot Pinto.;Andrea Benedetti.;Pei Zhi Li.;Wan C Tan.;Shawn D Aaron.;Kenneth R Chapman.;J Mark FitzGerald.;Paul Hernandez.;Darcy D Marciniuk.;François Maltais.;Denis E O'Donnell.;Don Sin.;Brandie L Walker.;Jean Bourbeau.; .
来源: Chest. 2016年150卷5期1069-1079页
The COPD Assessment Test (CAT) is a valid disease-specific questionnaire measuring health status. However, knowledge concerning its use regarding patient and disease characteristics remains limited. Our main objective was to assess the degree to which the CAT score varies and can discriminate between specific patient population groups.
10. Long-term Anticoagulation With Rivaroxaban for Preventing Recurrent VTE: A Benefit-Risk Analysis of EINSTEIN-Extension.
作者: Philip S Wells.;Martin H Prins.;Bennett Levitan.;Jan Beyer-Westendorf.;Timothy A Brighton.;Henri Bounameaux.;Alexander T Cohen.;Bruce L Davidson.;Paolo Prandoni.;Gary E Raskob.;Zhong Yuan.;Eva G Katz.;Martin Gebel.;Anthonie W A Lensing.
来源: Chest. 2016年150卷5期1059-1068页
Short-term anticoagulant treatment for acute DVT or pulmonary embolism (PE) effectively reduces the risk of recurrent disease during the first 6 to 12 months of therapy. Continued anticoagulation often is not instituted because of the perception among physicians that the risk of major bleeding will outweigh the risk of new venous thrombotic episodes.
11. Single-Breath Washout Tests to Assess Small Airway Disease in COPD.
作者: Lucas Boeck.;Anna Gensmer.;Sylvia Nyilas.;Bram Stieltjes.;Thomas J Re.;Michael Tamm.;Philipp Latzin.;Daiana Stolz.
来源: Chest. 2016年150卷5期1091-1100页
Current functional assessments do not allow a reliable assessment of small airways, which are a major site of disease in COPD. Single-breath washout (SBW) tests are feasible and reproducible methods for evaluating small airway disease. Their relevance in COPD remains unknown.
12. Acute Effects of Nasal CPAP in Patients With Hypertrophic Cardiomyopathy.
作者: Flávia B Nerbass.;Vera M C Salemi.;Rodrigo P Pedrosa.;Natanael de P Portilho.;Julio C A Ferreira-Filho.;Henrique T Moriya.;Murillo O Antunes.;Edmundo Arteaga-Fernández.;Luciano F Drager.;Geraldo Lorenzi-Filho.
来源: Chest. 2016年150卷5期1050-1058页
Hypertrophic cardiomyopathy (HCM) is a common genetic disease that may cause left ventricular outflow tract (LVOT) obstruction, heart failure, and sudden death. Recent studies have shown a high prevalence of OSA among patients with HCM. Because the hemodynamics in patients with LVOT obstruction are unstable and depend on the loading conditions of the heart, we evaluated the acute effects of CPAP on hemodynamics and cardiac performance in patients with HCM.
13. Oral Low-dose Theophylline on Top of Inhaled Fluticasone-Salmeterol Does Not Reduce Exacerbations in Patients With Severe COPD: A Pilot Clinical Trial.
作者: Borja G Cosío.;Hanaa Shafiek.;Amanda Iglesias.;Aina Yanez.;Rocío Córdova.;Alexandre Palou.;Robert Rodriguez-Roisin.;Germán Peces-Barba.;Sergi Pascual.;Joaquim Gea.;Oriol Sibila.;Peter J Barnes.;Alvar Agusti.
来源: Chest. 2016年150卷1期123-30页
COPD is characterized by chronic inflammation. In vitro and ex vivo observations suggest that this inflammatory response is partially resistant to the effect of corticosteroids and that low-dose theophylline can restore this response via enhancement of histone deacetylase (HDAC) activity. Whether this occurs in vivo and what its potential clinical consequences are is unclear.
14. Reslizumab for Inadequately Controlled Asthma With Elevated Blood Eosinophil Levels: A Randomized Phase 3 Study.
作者: Leif Bjermer.;Catherine Lemiere.;Jorge Maspero.;Sivan Weiss.;James Zangrilli.;Matthew Germinaro.
来源: Chest. 2016年150卷4期789-798页
This phase 3 study further characterizes the efficacy and safety of reslizumab (a humanized anti-IL-5 monoclonal antibody) in patients aged 12 to 75 years with asthma inadequately controlled by at least a medium-dose inhaled corticosteroid and with a blood eosinophil count ≥ 400 cells/μL.
15. A Prospective, Randomized, Double-Blind Trial Comparing the Diagnostic Yield of 21- and 22-Gauge Aspiration Needles for Performing Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in Sarcoidosis.
作者: Valliappan Muthu.;Nalini Gupta.;Sahajal Dhooria.;Inderpaul Singh Sehgal.;Amanjit Bal.;Ashutosh N Aggarwal.;Digambar Behera.;Ritesh Agarwal.
来源: Chest. 2016年149卷4期1111-3页 16. Oxygen With Cold Bubble Humidification Is No Better Than Dry Oxygen in Preventing Mucus Dehydration, Decreased Mucociliary Clearance, and Decline in Pulmonary Function.
作者: Michelle Lisidati Franchini.;Rodrigo Athanazio.;Luis Fernando Amato-Lourenço.;Waldir Carreirão-Neto.;Paulo Hilario Nascimento Saldiva.;Geraldo Lorenzi-Filho.;Bruce K Rubin.;Naomi Kondo Nakagawa.
来源: Chest. 2016年150卷2期407-14页
Little is known about the effects of long-term nasal low-flow oxygen (NLFO) on mucus and symptoms and how this variable is affected by dry or cold humidified gas. The aim of this study was to investigate the effects of dry-NLFO and cold bubble humidified-NLFO on nasal mucociliary clearance (MCC), mucus properties, inflammation, and symptoms in subjects with chronic hypoxemia requiring long-term domiciliary oxygen therapy.
17. B-Type Natriuretic Peptide, Aldosterone, and Fluid Management in ARDS.
作者: Matthew W Semler.;Annis M Marney.;Todd W Rice.;Hui Nian.;Chang Yu.;Arthur P Wheeler.;Nancy J Brown.; .
来源: Chest. 2016年150卷1期102-11页
Conservative fluid management increases ventilator-free days without influencing overall mortality in acute respiratory distress syndrome. Plasma concentrations of B-type natriuretic peptide (a marker of ventricular filling) or aldosterone (a marker of effective circulating volume) may identify patients for whom fluid management impacts survival.
18. Phase 3 Study of Reslizumab in Patients With Poorly Controlled Asthma: Effects Across a Broad Range of Eosinophil Counts.
作者: Jonathan Corren.;Steven Weinstein.;Lindsay Janka.;James Zangrilli.;Margaret Garin.
来源: Chest. 2016年150卷4期799-810页
IL-5, a mediator of eosinophil activity, is an important potential treatment target in patients with uncontrolled asthma. The efficacy of reslizumab, a humanized anti-human IL-5 monoclonal antibody, has been characterized in patients with blood eosinophils ≥ 400 cells/μL. This study further characterizes the efficacy and safety of reslizumab in patients with poorly-controlled asthma, particularly those with eosinophils < 400 cells/μL.
19. Motivational Enhancement for Increasing Adherence to CPAP: A Randomized Controlled Trial.
作者: Jessie P Bakker.;Rui Wang.;Jia Weng.;Mark S Aloia.;Claudia Toth.;Michael G Morrical.;Kevin J Gleason.;Michael Rueschman.;Cynthia Dorsey.;Sanjay R Patel.;James H Ware.;Murray A Mittleman.;Susan Redline.
来源: Chest. 2016年150卷2期337-45页
Motivational enhancement (ME) shows promise as a means of increasing adherence to CPAP for OSA.
20. Effect of Continuous Positive Airway Pressure on Cardiovascular Biomarkers: The Sleep Apnea Stress Randomized Controlled Trial.
作者: Hugo L Paz Y Mar.;Stanley L Hazen.;Russell P Tracy.;Kingman P Strohl.;Dennis Auckley.;James Bena.;Lu Wang.;Harneet K Walia.;Sanjay R Patel.;Reena Mehra.
来源: Chest. 2016年150卷1期80-90页
Although existing research highlights the relationship of OSA and cardiovascular disease, the effect of OSA treatment on cardiovascular biomarkers remains unclear. We evaluated the effect of OSA treatment on oxidative stress/inflammation measures.
|