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1872. A comparison of health expectancies over two decades in England: results of the Cognitive Function and Ageing Study I and II.
作者: Carol Jagger.;Fiona E Matthews.;Pia Wohland.;Tony Fouweather.;Blossom C M Stephan.;Louise Robinson.;Antony Arthur.;Carol Brayne.; .
来源: Lancet. 2016年387卷10020期779-86页
Whether rises in life expectancy are increases in good-quality years is of profound importance worldwide, with population ageing. We investigate how various health expectancies have changed in England between 1991 and 2011, with identical study design and methods in each decade.
1873. Effects of evidence-based strategies to reduce the socioeconomic gradient of uptake in the English NHS Bowel Cancer Screening Programme (ASCEND): four cluster-randomised controlled trials.
作者: Jane Wardle.;Christian von Wagner.;Ines Kralj-Hans.;Stephen P Halloran.;Samuel G Smith.;Lesley M McGregor.;Gemma Vart.;Rosemary Howe.;Julia Snowball.;Graham Handley.;Richard F Logan.;Sandra Rainbow.;Steve Smith.;Mary C Thomas.;Nicholas Counsell.;Steve Morris.;Stephen W Duffy.;Allan Hackshaw.;Sue Moss.;Wendy Atkin.;Rosalind Raine.
来源: Lancet. 2016年387卷10020期751-9页
Uptake in the national colorectal cancer screening programme in England varies by socioeconomic status. We assessed four interventions aimed at reducing this gradient, with the intention of improving the health benefits of screening.
1877. Ibrutinib versus temsirolimus in patients with relapsed or refractory mantle-cell lymphoma: an international, randomised, open-label, phase 3 study.
作者: Martin Dreyling.;Wojciech Jurczak.;Mats Jerkeman.;Rodrigo Santucci Silva.;Chiara Rusconi.;Marek Trneny.;Fritz Offner.;Dolores Caballero.;Cristina Joao.;Mathias Witzens-Harig.;Georg Hess.;Isabelle Bence-Bruckler.;Seok-Goo Cho.;John Bothos.;Jenna D Goldberg.;Christopher Enny.;Shana Traina.;Sriram Balasubramanian.;Nibedita Bandyopadhyay.;Steven Sun.;Jessica Vermeulen.;Aleksandra Rizo.;Simon Rule.
来源: Lancet. 2016年387卷10020期770-8页
Mantle-cell lymphoma is an aggressive B-cell lymphoma with a poor prognosis. Both ibrutinib and temsirolimus have shown single-agent activity in patients with relapsed or refractory mantle-cell lymphoma. We undertook a phase 3 study to assess the efficacy and safety of ibrutinib versus temsirolimus in relapsed or refractory mantle-cell lymphoma.
1879. Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia-TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial.
作者: Russell E Ware.;Barry R Davis.;William H Schultz.;R Clark Brown.;Banu Aygun.;Sharada Sarnaik.;Isaac Odame.;Beng Fuh.;Alex George.;William Owen.;Lori Luchtman-Jones.;Zora R Rogers.;Lee Hilliard.;Cynthia Gauger.;Connie Piccone.;Margaret T Lee.;Janet L Kwiatkowski.;Sherron Jackson.;Scott T Miller.;Carla Roberts.;Matthew M Heeney.;Theodosia A Kalfa.;Stephen Nelson.;Hamayun Imran.;Kerri Nottage.;Ofelia Alvarez.;Melissa Rhodes.;Alexis A Thompson.;Jennifer A Rothman.;Kathleen J Helton.;Donna Roberts.;Jamie Coleman.;Melanie J Bonner.;Abdullah Kutlar.;Niren Patel.;John Wood.;Linda Piller.;Peng Wei.;Judy Luden.;Nicole A Mortier.;Susan E Stuber.;Naomi L C Luban.;Alan R Cohen.;Sara Pressel.;Robert J Adams.
来源: Lancet. 2016年387卷10019期661-670页
For children with sickle cell anaemia and high transcranial doppler (TCD) flow velocities, regular blood transfusions can effectively prevent primary stroke, but must be continued indefinitely. The efficacy of hydroxycarbamide (hydroxyurea) in this setting is unknown; we performed the TWiTCH trial to compare hydroxyurea with standard transfusions.
1880. Weight change between successive pregnancies and risks of stillbirth and infant mortality: a nationwide cohort study.
Maternal overweight and obesity are risk factors for stillbirth and infant mortality. Whether temporal changes in maternal weight affect these risks is not clear. We aimed to assess whether change of BMI between first and second pregnancies affects risks of stillbirth and infant mortality in the second-born offspring.
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