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162. High-definition endoscopy with digital chromoendoscopy for histologic prediction of distal colorectal polyps.
作者: Timo Rath.;Gian E Tontini.;Andreas Nägel.;Michael Vieth.;Steffen Zopf.;Claudia Günther.;Arthur Hoffman.;Markus F Neurath.;Helmut Neumann.
来源: BMC Gastroenterol. 2015年15卷145页
Distal diminutive colorectal polyps are common and accurate endoscopic prediction of hyperplastic or adenomatous polyp histology could reduce procedural time, costs and potential risks associated with the resection. Within this study we assessed whether digital chromoendoscopy can accurately predict the histology of distal diminutive colorectal polyps according to the ASGE PIVI statement.
163. Evaluation of the role of HLA-DR antigens in Japanese type 1 autoimmune hepatitis.
作者: Yohei Furumoto.;Toru Asano.;Tomonori Sugita.;Hiroshi Abe.;Yoshimichi Chuganji.;Kazuhiko Fujiki.;Akihiko Sakata.;Yoshio Aizawa.
来源: BMC Gastroenterol. 2015年15卷144页
The role of HLA-DR antigens in the clinicopathological features of autoimmune hepatitis (AIH) is not clearly understood. We examined the implications of HLA-DR antigens in Japanese AIH, including the effect of HLA-DR4 on the age and pattern of AIH onset, clinicopathological features, and treatment efficacy.
164. Gastric cancer diagnosed after Helicobacter pylori eradication in diabetes mellitus patients.
作者: Kosuke Sakitani.;Yoshihiro Hirata.;Nobumi Suzuki.;Satoki Shichijo.;Ayako Yanai.;Takako Serizawa.;Kei Sakamoto.;Masao Akanuma.;Shin Maeda.;Yutaka Yamaji.;Yasuhiko Iwamoto.;Shoji Kawazu.;Kazuhiko Koike.
来源: BMC Gastroenterol. 2015年15卷143页
Helicobacter pylori infection is the most important risk factor for gastric cancer, for which eradication therapy is commonly performed. However, gastric cancer is sometimes discovered after successful eradication of H. pylori. Much evidence indicates that diabetes mellitus (DM) is a risk factor for gastric cancer. The incidence and characteristics of gastric cancer diagnosed after H. pylori eradication in DM patients remain to be determined.
165. Does the Tokyo guidelines predict the extent of gallbladder inflammation in patients with acute cholecystitis? A single center retrospective analysis.
The Tokyo guidelines provide criteria for the diagnosis and classification of acute cholecystitis in three severity grades. However, no data exists on the predictive value of these guidelines. The aim of this study was to analyze the accuracy of the Tokyo guidelines as a predicting parameter for the severity of acute cholecystitis in patients undergoing laparoscopic cholecystectomy.
167. Hepatic Arterial Infusion of Low-Density Lipoprotein Docosahexaenoic Acid Nanoparticles Selectively Disrupts Redox Balance in Hepatoma Cells and Reduces Growth of Orthotopic Liver Tumors in Rats.
作者: Xiaodong Wen.;Lacy Reynolds.;Rohit S Mulik.;Soo Young Kim.;Tim Van Treuren.;Liem H Nguyen.;Hao Zhu.;Ian R Corbin.
来源: Gastroenterology. 2016年150卷2期488-98页
Dietary intake of the natural omega-3 fatty acid docosahexaenoic acid (DHA) has been implicated in protecting patients with viral hepatitis B or C from developing hepatocellular carcinoma (HCC). Little is known about the effects of DHA on established solid tumors. Here we describe a low-density lipoprotein-based nanoparticle that acts as a transporter for unesterified DHA (LDL-DHA) and demonstrates selective cytotoxicity toward HCC cells. We investigated the ability of LDL-DHA to reduce growth of orthotopic hepatomas in rats.
168. Statins Are Associated With a Decreased Risk of Decompensation and Death in Veterans With Hepatitis C-Related Compensated Cirrhosis.
Statins decrease portal pressure in patients with cirrhosis and increase survival times of patients who have bled from varices. However, statins can be hepatotoxic. It is important to determine whether long-term statin use will be beneficial or detrimental for patients with cirrhosis because physicians are reluctant to prescribe statins to patients with liver disease. We investigated the effects of statins on decompensation and survival times in patients with compensated cirrhosis.
169. Differences in Alimentary Glucose Absorption and Intestinal Disposal of Blood Glucose After Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy.
作者: Jean-Baptiste Cavin.;Anne Couvelard.;Rachida Lebtahi.;Robert Ducroc.;Konstantinos Arapis.;Eglantine Voitellier.;Françoise Cluzeaud.;Laura Gillard.;Muriel Hourseau.;Nidaa Mikail.;Lara Ribeiro-Parenti.;Nathalie Kapel.;Jean-Pierre Marmuse.;André Bado.;Maude Le Gall.
来源: Gastroenterology. 2016年150卷2期454-64.e9页
Bariatric procedures, such as Roux-en-Y gastric bypass (RYGB) or vertical sleeve gastrectomy (VSG), are the most effective approaches to resolve type 2 diabetes in obese individuals. Alimentary glucose absorption and intestinal disposal of blood glucose have not been directly compared between individuals or animals that underwent RYGB vs VSG. We evaluated in rats and humans how the gut epithelium adapts after surgery and the consequences on alimentary glucose absorption and intestinal disposal of blood glucose.
170. Activity of SHIP, Which Prevents Expression of Interleukin 1β, Is Reduced in Patients With Crohn's Disease.
作者: Eyler N Ngoh.;Shelley B Weisser.;Young Lo.;Lisa K Kozicky.;Roger Jen.;Hayley K Brugger.;Susan C Menzies.;Keith W McLarren.;Dominika Nackiewicz.;Nico van Rooijen.;Kevan Jacobson.;Jan A Ehses.;Stuart E Turvey.;Laura M Sly.
来源: Gastroenterology. 2016年150卷2期465-76页
Crohn's disease (CD) is associated with a dysregulated immune response to commensal micro-organisms in the intestine. Mice deficient in inositol polyphosphate 5'-phosphatase D (INPP5D, also known as SHIP) develop intestinal inflammation resembling that of patients with CD. SHIP is a negative regulator of PI3Kp110α activity. We investigated mechanisms of intestinal inflammation in Inpp5d(-/-) mice (SHIP-null mice), and SHIP levels and activity in intestinal tissues of subjects with CD.
171. Prevalence of inflammatory bowel disease among coeliac disease patients in a Hungarian coeliac centre.
作者: Dorottya Kocsis.;Zsuzsanna Tóth.;Ágnes A Csontos.;Pál Miheller.;Péter Pák.;László Herszényi.;Miklós Tóth.;Zsolt Tulassay.;Márk Juhász.
来源: BMC Gastroenterol. 2015年15卷141页
Celiac disease, Crohn disease and ulcerative colitis are inflammatory disorders of the gastrointestinal tract with some common genetic, immunological and environmental factors involved in their pathogenesis. Several research shown that patients with celiac disease have increased risk of developing inflammatory bowel disease when compared with that of the general population. The aim of this study is to determine the prevalence of inflammatory bowel disease in our celiac patient cohort over a 15-year-long study period.
175. Urine neutrophil gelatinase-associated lipocalin: a diagnostic and prognostic marker for acute kidney injury (AKI) in hospitalized cirrhotic patients with AKI-prone conditions.
作者: Sombat Treeprasertsuk.;Amornpun Wongkarnjana.;Veeravich Jaruvongvanich.;Sasipim Sallapant.;Khajohn Tiranathanagul.;Piyawat Komolmit.;Pisit Tangkijvanich.
来源: BMC Gastroenterol. 2015年15卷140页
Acute kidney injury (AKI) is known to increase mortality in hospitalized cirrhotic patients; therefore early identification is utmost significance. There are only a few studies evaluating the cut-off level of urine neutrophil gelatinase-associated lipocalin (uNGAL) for diagnosing AKI and its prognostic value in cirrhotic patients. We aimed to determine the accuracy of uNGAL as a biomarker for early identification of AKI and to determine the cut-off level of uNGAL for diagnosing AKI in hospitalized cirrhotic patients; and (2) to explore the association of 30-day liver-related mortality with uNGAL level.
176. Trans-anal irrigation therapy to treat adult chronic functional constipation: systematic review and meta-analysis.
作者: Christopher D Emmett.;Helen J Close.;Yan Yiannakou.;James M Mason.
来源: BMC Gastroenterol. 2015年15卷139页
Trans-anal irrigation (TAI) is used widely to treat bowel dysfunction, although evidence for its use in adult chronic functional constipation remains unclear. Long-term outcome data are lacking, and the effectiveness of therapy in this patient group is not definitively known.
177. Systematic review of the impact of feed protein type and degree of hydrolysis on gastric emptying in children.
作者: Rosan Meyer.;Ru-Xin Melanie Foong.;Nikhil Thapar.;Stamatiki Kritas.;Neil Shah.
来源: BMC Gastroenterol. 2015年15卷137页
The choice of infant formula is thought to play an important role on gastric emptying (GE) in a variety of gastrointestinal disorders. It is known that many ingredients impact on GE, including the type of protein and level of hydrolysis. In clinical practice, feeds are often recommended due to putative improved GE related to the type of protein and level of hydrolysis, however whether this is scientifically justified still needs to be established. A systematic review comparing the impact of protein type and hydrolysis on GE in children was therefore performed.
178. Long-term follow-up of non-operated patients with symptomatic gallbladder stones: a retrospective study evaluating the role of Hepatobiliary scanning.
作者: Keun Soo Ahn.;Ho-Seong Han.;Jai Young Cho.;Yoo-Seok Yoon.;Chulhan Kim.;Won Woo Lee.
来源: BMC Gastroenterol. 2015年15卷136页
To assess hepatobiliary (HB) scans for predicting recurrent symptoms in nonoperated patients with mild or vague symptomatic gallstones.
179. Cap-assisted hemoclip application with forward-viewing endoscope for hemorrhage induced by endoscopic sphincterotomy: a prospective case series study.
Endoscopic sphincterotomy (ES) is a therapeutic technique developed as an advanced application of endoscopic retrograde cholangiopancreatography (ERCP). An important adverse event associated with this procedure is hemorrhage, which may sometimes be uncontrollable. We sought to examine whether cap-assisted hemoclip application is effective in controlling ES-induced hemorrhage.
180. Excessive intraoperative blood loss independently predicts recurrence of hepatocellular carcinoma after liver transplantation.
作者: Bing Liu.;Fei Teng.;Hong Fu.;Wen-Yuan Guo.;Xiao-Min Shi.;Zhi-Jia Ni.;Xiao-Gang Gao.;Jun Ma.;Zhi-Ren Fu.;Guo-Shan Ding.
来源: BMC Gastroenterol. 2015年15卷138页
Several studies have investigated the effect of intraoperative blood loss (IBL) on recurrence of tumors. However, the independent effect of IBL on oncological outcome after liver transplantation (LT) for hepatocellular carcinoma (HCC) is unclear.
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