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161. Sofosbuvir and Velpatasvir for HCV in Patients with Decompensated Cirrhosis.
作者: Michael P Curry.;Jacqueline G O'Leary.;Natalie Bzowej.;Andrew J Muir.;Kevin M Korenblat.;Jonathan M Fenkel.;K Rajender Reddy.;Eric Lawitz.;Steven L Flamm.;Thomas Schiano.;Lewis Teperman.;Robert Fontana.;Eugene Schiff.;Michael Fried.;Brian Doehle.;Di An.;John McNally.;Anu Osinusi.;Diana M Brainard.;John G McHutchison.;Robert S Brown.;Michael Charlton.; .
来源: N Engl J Med. 2015年373卷27期2618-28页
As the population that is infected with the hepatitis C virus (HCV) ages, the number of patients with decompensated cirrhosis is expected to increase.
162. Images in Clinical Medicine. Central Retinal-Vein Occlusion.
A 43-year-old man presented with sudden painless loss of vision in his left eye. Funduscopic examination revealed hyperemia and swelling of the optic nerve, macular edema, diffuse intraretinal hemorrhages, and dilated and tortuous retinal veins.
164. Acquired Resistance to Bedaquiline and Delamanid in Therapy for Tuberculosis.
作者: Guido V Bloemberg.;Peter M Keller.;David Stucki.;Andrej Trauner.;Sonia Borrell.;Tsogyal Latshang.;Mireia Coscolla.;Thomas Rothe.;Rico Hömke.;Claudia Ritter.;Julia Feldmann.;Bettina Schulthess.;Sebastien Gagneux.;Erik C Böttger.
来源: N Engl J Med. 2015年373卷20期1986-8页
Treatment of multidrug-resistant Mycobacterium tuberculosis is a challenge. This letter describes the emergence of resistance to new therapies, bedaquiline and delamanid.
165. Biallelic NTHL1 Mutations in a Woman with Multiple Primary Tumors.
作者: Barbara Rivera.;Ester Castellsagué.;Ismaël Bah.;Léon C van Kempen.;William D Foulkes.
来源: N Engl J Med. 2015年373卷20期1985-6页
A patient is described with multiple cancers and compound heterozygous mutations in NTHL1, a recently described polyposis gene. The involvement of a second causative mutation is reported.
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