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141. Older age is associated with more MRI-detected inflammation in hand and foot joints.
作者: Wouter P Nieuwenhuis.;Lukas Mangnus.;Hanna W van Steenbergen.;Elize C Newsum.;Tom W J Huizinga.;Monique Reijnierse.;Annette H M van der Helm-van Mil.
来源: Rheumatology (Oxford). 2016年55卷12期2212-2219页
Although MRI is recommended for diagnostic use in detecting joint inflammation, its value in clinical practice has not been settled. Older symptom-free persons show more MRI-detected inflammation in their hands and feet. Within arthritis patients, a similar effect could be present (a general age effect). The association of age with MRI inflammation could also be enhanced by disease (disease-dependent age effect). Because both effects could have diagnostic consequences, we evaluated the association between age-at-onset and MRI-detected inflammation in early arthritis and RA.
146. Cortical bone density and thickness alterations by high-resolution peripheral quantitative computed tomography: association with vertebral fractures in primary Sjögren's syndrome.
作者: Sandra G Pasoto.;Kristopherson L Augusto.;Jackeline C Alvarenga.;Liliam Takayama.;Ricardo M Oliveira.;Eloisa Bonfa.;Rosa M R Pereira.
来源: Rheumatology (Oxford). 2016年55卷12期2200-2211页
To evaluate volumetric BMD (vBMD), microarchitecture and strength and vertebral fractures (VFs) in primary SS (pSS).
147. The influence of obesity on response to tumour necrosis factor-α inhibitors in psoriatic arthritis: results from the DANBIO and ICEBIO registries.
作者: Pil Højgaard.;Bente Glintborg.;Lars Erik Kristensen.;Bjorn Gudbjornsson.;Thorvardur Jon Love.;Lene Dreyer.
来源: Rheumatology (Oxford). 2016年55卷12期2191-2199页
To investigate the impact of obesity on response to the first TNF-α inhibitor (TNFI) treatment course in patients with PsA followed in routine care.
148. Improvement in insulin resistance is greater when infliximab is added to methotrexate during intensive treatment of early rheumatoid arthritis-results from the IDEA study.
作者: Lesley-Anne Bissell.;Elizabeth M A Hensor.;Lukasz Kozera.;Sarah L Mackie.;Agata N Burska.;Jacqueline L Nam.;Helen Keen.;Edith Villeneuve.;Helena Donica.;Maya H Buch.;Philip G Conaghan.;Jacqueline Andrews.;Paul Emery.;Ann W Morgan.
来源: Rheumatology (Oxford). 2016年55卷12期2181-2190页
To determine the change in established biomarkers of cardiovascular (CV) risk, namely, total cholesterol/high-density lipoprotein cholesterol ratio (TC/HDL-C), N-terminal pro-brain natriuretic peptide (NT-proBNP) and insulin resistance (IR) in patients with early RA treated with two different treat-to-target strategies.
149. A population study of the reported incidence of native joint septic arthritis in the United Kingdom between 1998 and 2013.
作者: Andrew I Rutherford.;Sujith Subesinghe.;Tehmina Bharucha.;Fowzia Ibrahim.;Alexander Kleymann.;James B Galloway.
来源: Rheumatology (Oxford). 2016年55卷12期2176-2180页
Septic arthritis is a life-threatening condition with mortality rates of 10-15%. Previous studies in other countries have shown the incidence of septic arthritis may be changing. Our aim was investigate the incidence and pattern of native joint septic arthritis in the UK.
150. Magnetic resonance imaging-detected inflammation is associated with functional disability in early arthritis-results of a cross-sectional study.
作者: Leonie E Burgers.;Wouter P Nieuwenhuis.;Hanna W van Steenbergen.;Elize C Newsum.;Tom W J Huizinga.;Monique Reijnierse.;Saskia le Cessie.;Annette H M van der Helm-van Mil.
来源: Rheumatology (Oxford). 2016年55卷12期2167-2175页
MRI sensitively detects inflammation, but the clinical relevance of MRI-detected inflammation is undetermined in early arthritis. Therefore, the aim of this cross-sectional study was to investigate the association between MRI-detected inflammation of hands and feet and functional disability in early arthritis.
151. High mobility group box 1 skews macrophage polarization and negatively influences phagocytosis of apoptotic cells.
作者: Fleur Schaper.;Karina de Leeuw.;Gerda Horst.;Hendrika Bootsma.;Pieter C Limburg.;Peter Heeringa.;Marc Bijl.;Johanna Westra.
来源: Rheumatology (Oxford). 2016年55卷12期2260-2270页
Decreased phagocytosis of apoptotic cells plays an important role in the pathogenesis of SLE. This can lead to secondary necrosis and release of nuclear proteins, such as high mobility group box 1 (HMGB1). We hypothesized that increased HMGB1 levels, as present in SLE, skew macrophage differentiation towards M1-like phenotypes and thereby diminish uptake of apoptotic cells. The aim of this study was to investigate the effect of HMGB1 on macrophage polarization and on phagocytic capacity of differentiated macrophages.
156. The prolactin receptor is expressed in rheumatoid arthritis and psoriatic arthritis synovial tissue and contributes to macrophage activation.
作者: Man Wai Tang.;Kris A Reedquist.;Samuel Garcia.;Bea Malvar Fernandez.;Veronica Codullo.;Elsa Vieira-Sousa.;Vincent Goffin.;Anne Q Reuwer.;Marcel T Twickler.;Daniëlle M Gerlag.;Paul-Peter Tak.
来源: Rheumatology (Oxford). 2016年55卷12期2248-2259页
Prolactin (PRL) is a lactation-inducing hormone with immunomodulatory properties and is found at elevated levels in the serum of patients with RA and other rheumatic diseases. The PRL receptor (PRLR) has been shown to be expressed by macrophages in atherosclerotic plaques. The aim of this study was to examine PRLR expression by synovial macrophages and its role in the regulation of macrophage activation.
157. Validity and sensitivity to change of the semi-quantitative OMERACT ultrasound scoring system for tenosynovitis in patients with rheumatoid arthritis.
作者: Mads Ammitzbøll-Danielsen.;Mikkel Østergaard.;Esperanza Naredo.;Lene Terslev.
来源: Rheumatology (Oxford). 2016年55卷12期2156-2166页
The aim was to evaluate the metric properties of the semi-quantitative OMERACT US scoring system vs a novel quantitative US scoring system for tenosynovitis, by testing its intra- and inter-reader reliability, sensitivity to change and comparison with clinical tenosynovitis scoring in a 6-month follow-up study.
158. Elevated serum levels of free interleukin-18 in adult-onset Still's disease.
作者: Charlotte Girard.;Jürgen Rech.;Michael Brown.;Danièle Allali.;Pascale Roux-Lombard.;François Spertini.;Eduardo J Schiffrin.;Georg Schett.;Bernhard Manger.;Sylvette Bas.;Greg Del Val.;Cem Gabay.
来源: Rheumatology (Oxford). 2016年55卷12期2237-2247页
IL-18 is a pro-inflammatory cytokine of the IL-1 family that is naturally inhibited by IL-18 binding protein (IL-18BP). High levels of IL-18 have been described in the serum of adult-onset Still's disease (AOSD) patients, but only total IL-18 levels (including inactive IL-18 bound to IL-18BP) have been measured. With a specific immunoassay, we aimed to measure free IL-18 serum levels in AOSD patients and other rheumatic diseases.
160. Calcinosis is associated with digital ischaemia in systemic sclerosis-a longitudinal study.
作者: Murray Baron.;Janet Pope.;David Robinson.;Niall Jones.;Nader Khalidi.;Peter Docherty.;Elzbieta Kaminska.;Ariel Masetto.;Evelyn Sutton.;Jean-Pierre Mathieu.;Sophie Ligier.;Tamara Grodzicky.;Sharon LeClercq.;Carter Thorne.;Geneviève Gyger.;Douglas Smith.;Paul R Fortin.;Maggie Larché.;Maysan Abu-Hakima.;Tatiana S Rodriguez-Reyna.;Antonio R Cabral-Castaneda.;Marvin J Fritzler.;Mianbo Wang.;Marie Hudson.
来源: Rheumatology (Oxford). 2016年55卷12期2148-2155页
To determine if ischaemia is a causal factor in the development of calcinosis in SSc.
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