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共有 32146 条符合本次的查询结果, 用时 2.1797782 秒

141. A Double-Blind Placebo-Controlled Study of the Effects of Olprinone, a Specific Phosphodiesterase III Inhibitor, for Preventing Postoperative Atrial Fibrillation in Patients Undergoing Pulmonary Resection for Lung Cancer.

作者: Takashi Nojiri.;Kazuhiro Yamamoto.;Hajime Maeda.;Yukiyasu Takeuchi.;Naoko Ose.;Yoshiyuki Susaki.;Masayoshi Inoue.;Meinoshin Okumura.
来源: Chest. 2015年148卷5期1285-1292页
We previously reported that patients with elevated preoperative B-type natriuretic peptide (BNP) levels have an increased risk for postoperative atrial fibrillation following lung cancer surgery. The present study evaluated whether the specific phosphodiesterase III inhibitor olprinone can reduce the incidence of postoperative atrial fibrillation in patients with elevated BNP levels undergoing pulmonary resection for lung cancer.

142. Pulseless Oximetry: A Preliminary Evaluation.

作者: Thomas K Aldrich.;Pragya Gupta.;Sean P Stoy.;Anthony Carlese.;Daniel J Goldstein.
来源: Chest. 2015年148卷6期1484-1488页
Pulse oximetry fails when pulsations are weak or absent, common in patients with continuous flow left ventricular assist devices (LVADs). We developed a method to measure arterial oxygenation (Sao2) noninvasively in pulseless patients with LVADs.

143. Advances in molecular biology of lung disease: aiming for precision therapy in non-small cell lung cancer.

作者: Claire Rooney.;Tariq Sethi.
来源: Chest. 2015年148卷4期1063-1072页
Lung cancer is the principal cause of cancer-related mortality in the developed world, accounting for almost one-quarter of all cancer deaths. Traditional treatment algorithms have largely relied on histologic subtype and have comprised pragmatic chemotherapy regimens with limited efficacy. However, because our understanding of the molecular basis of disease in non-small cell lung cancer (NSCLC) has improved exponentially, it has become apparent that NSCLC can be radically subdivided, or molecularly characterized, based on recurrent driver mutations occurring in specific oncogenes. We know that the presence of such mutations leads to constitutive activation of aberrant signaling proteins that initiate, progress, and sustain tumorigenesis. This persistence of the malignant phenotype is referred to as "oncogene addiction." On this basis, a paradigm shift in treatment approach has occurred. Rational, targeted therapies have been developed, the first being tyrosine kinase inhibitors (TKIs), which entered the clinical arena > 10 years ago. These were tremendously successful, significantly affecting the natural history of NSCLC and improving patient outcomes. However, the benefits of these drugs are somewhat limited by the emergence of adaptive resistance mechanisms, and efforts to tackle this phenomenon are ongoing. A better understanding of all types of oncogene-driven NSCLC and the occurrence of TKI resistance will help us to further develop second- and third-generation small molecule inhibitors and will expand our range of precision therapies for this disease.

144. Sleep-Related Breathing Disorders and the Chiari 1 Malformation.

作者: Roberta M Leu.
来源: Chest. 2015年148卷5期1346-1352页
The Chiari 1 malformation is characterized by > 5-mm herniation of the cerebellar tonsils through the foramen magnum. Consequent compression of the brain stem and nearby neuronal structures involved in respiratory control and maintenance of pharyngeal wall muscle tone may result in respiratory changes during sleep. These changes include respiratory failure and arrest, as well as sleep-related breathing disorders (ie, OSA and central sleep apnea). Although data have accrued on the significance of sleep-related breathing disorders in patients with the Chiari 1 malformation, many management questions remain unanswered. This article reviews the available literature on prevalence and management of sleep-related breathing disorders in patients with the Chiari 1 malformation.

145. Hepatopulmonary syndrome is a frequent cause of dyspnea in the short telomere disorders.

作者: Amany I Gorgy.;Naudia L Jonassaint.;Susan E Stanley.;Ayman Koteish.;Amy E DeZern.;Jolan E Walter.;Sabrina C Sopha.;James P Hamilton.;Julie Hoover-Fong.;Allen R Chen.;Robert A Anders.;Ihab R Kamel.;Mary Armanios.
来源: Chest. 2015年148卷4期1019-1026页
Telomere syndromes have their most common manifestation in idiopathic pulmonary fibrosis and emphysema. The short telomere defect in these patients may manifest systemically as bone marrow failure and liver disease. We sought to understand the causes of dyspnea in telomerase and telomere gene mutation carriers who have no parenchymal lung disease.

146. Randomized Trial of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration With and Without Rapid On-site Evaluation for Lung Cancer Genotyping.

作者: Rocco Trisolini.;Alessandra Cancellieri.;Carmine Tinelli.;Dario de Biase.;Ilaria Valentini.;Gianpiero Casadei.;Daniela Paioli.;Franco Ferrari.;Giovanni Gordini.;Marco Patelli.;Giovanni Tallini.
来源: Chest. 2015年148卷6期1430-1437页
Experts and scientific society guidelines recommend that rapid on-site evaluation (ROSE) be used with endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) to optimize lung cancer genotyping, but no comparative trial has been carried out to confirm and quantify its usefulness.

147. Delirium and Circadian Rhythm of Melatonin During Weaning From Mechanical Ventilation: An Ancillary Study of a Weaning Trial.

作者: Armand Mekontso Dessap.;Ferran Roche-Campo.;Jean-Marie Launay.;Anais Charles-Nelson.;Sandrine Katsahian.;Christian Brun-Buisson.;Laurent Brochard.
来源: Chest. 2015年148卷5期1231-1241页
Delirium is frequent in patients in the ICU, but its association with the outcome of weaning from mechanical ventilation has not been assessed. Circadian rhythm alteration may favor delirium. In the current study, we assessed the impact of delirium during weaning and associated alterations in the circadian rhythm of melatonin excretion.

148. A 70-Year-Old Man With Large Cervical and Mediastinal Lymphadenopathies.

作者: Shraddha Narechania.;Jason Valent.;Carol Farver.;Adriano R Tonelli.
来源: Chest. 2015年148卷1期e8-e13页
We present a case of a 70-year-old man with enlarged mediastinal and cervical lymph nodes that provided interesting radiologic and pathologic observations. The 70-year-old black man was found to have enlarged mediastinal lymph nodes. He had symptoms of atypical chest pain and generalized weakness for 2 weeks prior to the diagnosis. He denied shortness of breath, fever, chills, or night sweats. He was treated for hypertension and onychomycosis. Basic laboratory findings were within normal limits. Pulmonary function tests at the time of presentation showed FEV1, FVC, and FEV1/FVC ratio of 123% predicted, 133% predicted, and 0.7, respectively. Meanwhile, total lung capacity and carbon monoxide diffusing capacity were 103% and 107% predicted, respectively. Two weeks before he presented to our institution, the patient underwent bronchoscopy with transbronchial biopsies of the right lower lobe and endobronchial ultrasound-guided transbronchial needle aspiration of the right hilar lymph nodes.

149. A Man in His 60s With Cirrhosis, Encephalopathy, and Shock.

作者: Ariel L Shiloh.;Muhammad Adrish.
来源: Chest. 2015年148卷1期e5-e7页

150. Response.

作者: Neil C Thomson.;Charles McSharry.;Rekha Chaudhuri.
来源: Chest. 2015年148卷1期e33-e34页

151. CT Scan Segmental Airway Lumen Area.

作者: David J Ross.;Victoria J Sebbage.
来源: Chest. 2015年148卷1期e33页

152. Response.

作者: Jason Rho.;Nancy Ho.;Vinay Prasad.
来源: Chest. 2015年148卷1期e31-e32页

153. Roflumilast in COPD.

作者: Erin Worndl.;Eoin B Hunt.;Marcus P Kennedy.;Michael T Henry.;Barry J Plant.;Desmond M Murphy.
来源: Chest. 2015年148卷1期e31页

154. Response.

作者: Richard D Hurt.;Joseph G Murphy.;William F Dunn.
来源: Chest. 2015年148卷1期e30页

155. Electronic Cigarettes: The Resistance Value of the Heating Filament Could Be the Key to Lung Toxicity.

作者: Pierre Chausse.;Geraldine Naughton.;Frédéric Dutheil.
来源: Chest. 2015年148卷1期e29-e30页

156. Response.

作者: Maria Vargas.;Paolo Pelosi.;Robert M Kacmarek.;Giuseppe Servillo.
来源: Chest. 2015年148卷1期e27-e28页

157. Assessment of Ventilation During the Performance of Elective Endoscopic-Guided Percutaneous Tracheostomy: What's New 10 Years Later?

作者: Fausto Ferraro.;Pierluigi Fusco.;Daniela Di Martino.;Annarita Torino.
来源: Chest. 2015年148卷1期e26-e28页

158. A 38-Year-Old Man With Obesity, Intermittent Tachycardia, and One Episode of Syncope.

作者: Karolina K Marinescu.;Mazhar Khan.;James A Rowley.;Teferi Y Mitiku.
来源: Chest. 2015年148卷1期e22-e25页
A 38-year-old man with history of diabetes, hypertension, hyperlipidemia, and obesity was referred to the electrophysiology clinic for evaluation of infrequent palpitations and remote history of syncope. The patient described a sensation of racing of the heart, which lasted about 30 min to 1 h and occurred several times over the past year. This was associated with a sense of anxiety and shortness of breath and appeared to resolve spontaneously. The patient also experienced one episode of syncope in the past while enjoying a barbecue on a hot summer day. He did not recall if this episode was accompanied by palpitations, however, the previously mentioned symptoms prompted the consultation. Upon further questioning the patient also reported experiencing fatigue. He stated that he noted decreased energy and frequent daytime sleepiness.

159. A 22-Year-Old Nonsmoker With Diffuse Cystic Lung Disease.

作者: Kimber Foust.;Jeffrey Albores.;Gregory A Fishbein.;Scott Genshaft.;Tisha Wang.
来源: Chest. 2015年148卷1期e18-e21页
A 22-year-old previously healthy woman was evaluated in pulmonary clinic for shortness of breath and cough that had been slowly progressive over 3 months. She otherwise reported being fully functional and attended her college graduation a week prior to evaluation. She had no history of smoking, illicit drug use, connective tissue disease, or noxious exposures.

160. A 50-Year-Old Man Presenting With Cough and an Endobronchial Lesion After Initiation of Highly Active Antiretroviral Therapy.

作者: Matthew A McCullough.;Chisa Aoyama.;Nader Kamangar.
来源: Chest. 2015年148卷1期e14-e17页
共有 32146 条符合本次的查询结果, 用时 2.1797782 秒