当前位置: 首页 >> 检索结果
147. Fully Implanted Brain-Computer Interface in a Locked-In Patient with ALS.
作者: Mariska J Vansteensel.;Elmar G M Pels.;Martin G Bleichner.;Mariana P Branco.;Timothy Denison.;Zachary V Freudenburg.;Peter Gosselaar.;Sacha Leinders.;Thomas H Ottens.;Max A Van Den Boom.;Peter C Van Rijen.;Erik J Aarnoutse.;Nick F Ramsey.
来源: N Engl J Med. 2016年375卷21期2060-2066页
Options for people with severe paralysis who have lost the ability to communicate orally are limited. We describe a method for communication in a patient with late-stage amyotrophic lateral sclerosis (ALS), involving a fully implanted brain-computer interface that consists of subdural electrodes placed over the motor cortex and a transmitter placed subcutaneously in the left side of the thorax. By attempting to move the hand on the side opposite the implanted electrodes, the patient accurately and independently controlled a computer typing program 28 weeks after electrode placement, at the equivalent of two letters per minute. The brain-computer interface offered autonomous communication that supplemented and at times supplanted the patient's eye-tracking device. (Funded by the Government of the Netherlands and the European Union; ClinicalTrials.gov number, NCT02224469 .).
148. Perioperative Ledipasvir-Sofosbuvir for HCV in Liver-Transplant Recipients.
作者: Josh Levitsky.;Elizabeth C Verna.;Jacqueline G O'Leary.;Natalie H Bzowej.;Dilip K Moonka.;Robert H Hyland.;Sarah Arterburn.;Hadas Dvory-Sobol.;Diana M Brainard.;John G McHutchison.;Norah A Terrault.
来源: N Engl J Med. 2016年375卷21期2106-2108页 152. TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes.
作者: John S Welch.;Allegra A Petti.;Christopher A Miller.;Catrina C Fronick.;Michelle O'Laughlin.;Robert S Fulton.;Richard K Wilson.;Jack D Baty.;Eric J Duncavage.;Bevan Tandon.;Yi-Shan Lee.;Lukas D Wartman.;Geoffrey L Uy.;Armin Ghobadi.;Michael H Tomasson.;Iskra Pusic.;Rizwan Romee.;Todd A Fehniger.;Keith E Stockerl-Goldstein.;Ravi Vij.;Stephen T Oh.;Camille N Abboud.;Amanda F Cashen.;Mark A Schroeder.;Meagan A Jacoby.;Sharon E Heath.;Kierstin Luber.;Megan R Janke.;Andrew Hantel.;Niloufer Khan.;Madina J Sukhanova.;Randall W Knoebel.;Wendy Stock.;Timothy A Graubert.;Matthew J Walter.;Peter Westervelt.;Daniel C Link.;John F DiPersio.;Timothy J Ley.
来源: N Engl J Med. 2016年375卷21期2023-2036页
The molecular determinants of clinical responses to decitabine therapy in patients with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) are unclear.
155. Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption.
作者: Katharine J Bar.;Michael C Sneller.;Linda J Harrison.;J Shawn Justement.;Edgar T Overton.;Mary E Petrone.;D Brenda Salantes.;Catherine A Seamon.;Benjamin Scheinfeld.;Richard W Kwan.;Gerald H Learn.;Michael A Proschan.;Edward F Kreider.;Jana Blazkova.;Mark Bardsley.;Eric W Refsland.;Michael Messer.;Katherine E Clarridge.;Nancy B Tustin.;Patrick J Madden.;KaSaundra Oden.;Sijy J O'Dell.;Bernadette Jarocki.;Andrea R Shiakolas.;Randall L Tressler.;Nicole A Doria-Rose.;Robert T Bailer.;Julie E Ledgerwood.;Edmund V Capparelli.;Rebecca M Lynch.;Barney S Graham.;Susan Moir.;Richard A Koup.;John R Mascola.;James A Hoxie.;Anthony S Fauci.;Pablo Tebas.;Tae-Wook Chun.
来源: N Engl J Med. 2016年375卷21期2037-2050页
The discovery of potent and broadly neutralizing antibodies (bNAbs) against human immunodeficiency virus (HIV) has made passive immunization a potential strategy for the prevention and treatment of HIV infection. We sought to determine whether passive administration of VRC01, a bNAb targeting the HIV CD4-binding site, can safely prevent or delay plasma viral rebound after the discontinuation of antiretroviral therapy (ART).
156. Thresholds for Abdominal Aortic Aneurysm Repair in England and the United States.
作者: Alan Karthikesalingam.;Alberto Vidal-Diez.;Peter J Holt.;Ian M Loftus.;Marc L Schermerhorn.;Peter A Soden.;Bruce E Landon.;Matthew M Thompson.
来源: N Engl J Med. 2016年375卷21期2051-2059页
Thresholds for repair of abdominal aortic aneurysms vary considerably among countries.
|