1041. Late Ebola virus relapse causing meningoencephalitis: a case report.
作者: Michael Jacobs.;Alison Rodger.;David J Bell.;Sanjay Bhagani.;Ian Cropley.;Ana Filipe.;Robert J Gifford.;Susan Hopkins.;Joseph Hughes.;Farrah Jabeen.;Ingolfur Johannessen.;Drosos Karageorgopoulos.;Angie Lackenby.;Rebecca Lester.;Rebecca S N Liu.;Alisdair MacConnachie.;Tabitha Mahungu.;Daniel Martin.;Neal Marshall.;Stephen Mepham.;Richard Orton.;Massimo Palmarini.;Monika Patel.;Colin Perry.;S Erica Peters.;Duncan Porter.;David Ritchie.;Neil D Ritchie.;R Andrew Seaton.;Vattipally B Sreenu.;Kate Templeton.;Simon Warren.;Gavin S Wilkie.;Maria Zambon.;Robin Gopal.;Emma C Thomson.
来源: Lancet. 2016年388卷10043期498-503页
There are thousands of survivors of the 2014 Ebola outbreak in west Africa. Ebola virus can persist in survivors for months in immune-privileged sites; however, viral relapse causing life-threatening and potentially transmissible disease has not been described. We report a case of late relapse in a patient who had been treated for severe Ebola virus disease with high viral load (peak cycle threshold value 13.2).
1043. Effects of aspirin on risk and severity of early recurrent stroke after transient ischaemic attack and ischaemic stroke: time-course analysis of randomised trials.
作者: Peter M Rothwell.;Ale Algra.;Zhengming Chen.;Hans-Christoph Diener.;Bo Norrving.;Ziyah Mehta.
来源: Lancet. 2016年388卷10042期365-375页
Aspirin is recommended for secondary prevention after transient ischaemic attack (TIA) or ischaemic stroke on the basis of trials showing a 13% reduction in long-term risk of recurrent stroke. However, the risk of major stroke is very high for only the first few days after TIA and minor ischaemic stroke, and observational studies show substantially greater benefits of early medical treatment in the acute phase than do longer-term trials. We hypothesised that the short-term benefits of early aspirin have been underestimated.
1046. The burden of mental, neurological, and substance use disorders in China and India: a systematic analysis of community representative epidemiological studies.
作者: Fiona J Charlson.;Amanda J Baxter.;Hui G Cheng.;Rahul Shidhaye.;Harvey A Whiteford.
来源: Lancet. 2016年388卷10042期376-389页
China and India jointly account for 38% of the world population, so understanding the burden attributed to mental, neurological, and substance use disorders within these two countries is essential. As part of the Lancet/Lancet Psychiatry China-India Mental Health Alliance Series, we aim to provide estimates of the burden of mental, neurological, and substance use disorders for China and India from the Global Burden of Disease Study 2013 (GBD 2013).
1048. Long-term evidence for the effect of pay-for-performance in primary care on mortality in the UK: a population study.
作者: Andrew M Ryan.;Sam Krinsky.;Evangelos Kontopantelis.;Tim Doran.
来源: Lancet. 2016年388卷10041期268-74页
Introduced in 2004, the UK's Quality and Outcomes Framework (QOF) is the world's largest primary care pay-for-performance programme. We tested whether the QOF was associated with reduced population mortality.
1052. Bioengineered human acellular vessels for dialysis access in patients with end-stage renal disease: two phase 2 single-arm trials.
作者: Jeffrey H Lawson.;Marc H Glickman.;Marek Ilzecki.;Tomasz Jakimowicz.;Andrzej Jaroszynski.;Eric K Peden.;Alison J Pilgrim.;Heather L Prichard.;Malgorzata Guziewicz.;Stanisław Przywara.;Jacek Szmidt.;Jakub Turek.;Wojciech Witkiewicz.;Norbert Zapotoczny.;Tomasz Zubilewicz.;Laura E Niklason.
来源: Lancet. 2016年387卷10032期2026-34页
For patients with end-stage renal disease who are not candidates for fistula, dialysis access grafts are the best option for chronic haemodialysis. However, polytetrafluoroethylene arteriovenous grafts are prone to thrombosis, infection, and intimal hyperplasia at the venous anastomosis. We developed and tested a bioengineered human acellular vessel as a potential solution to these limitations in dialysis access.
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