当前位置: 首页 >> 检索结果
85. Clinical characteristics and STK11 gene mutations in Chinese children with Peutz-Jeghers syndrome.
作者: Zhiheng Huang.;Shijian Miao.;Lin Wang.;Ping Zhang.;Bingbing Wu.;Jie Wu.;Ying Huang.
来源: BMC Gastroenterol. 2015年15卷166页
Peutz-Jeghers syndrome (PJS) is a rare autosomal dominant inherited disease characterized by gastrointestinal hamartomatous polyps and mucocutaneous melanin spots. Germline mutation of the serine/threonine kinase 11 (STK11) gene are responsible for PJS. In this study, we investigated the clinical characteristics and molecular basis of the disease in Chinese children with PJS.
86. Albumin treatment regimen for type 1 hepatorenal syndrome: a dose-response meta-analysis.
Recommended treatment for type 1 hepatorenal syndrome consists of albumin and vasoconstrictor. The optimal albumin dose remains poorly characterized. This meta-analysis aimed to determine the impact of albumin dose on treatment outcomes.
87. Prognostic impact of immunohistochemical expression of CK7 and CK20 in curatively resected ampulla of Vater cancer.
In the consideration of ampullary adenocarcinoma, T stage, lymph node metastases, perineural invasion, tumor differentiation, pancraticobiliary type, and lymph node ratio are considered prognostic factors. The objectives of this study were to investigate surgical outcomes and the clinicopathological predictors affecting survival and recurrence, and to examine the prognostic roles of histopathological subtype and immunohistochemical markers.
90. Liver X Receptor Regulates Triglyceride Absorption Through Intestinal Down-regulation of Scavenger Receptor Class B, Type 1.
作者: Olivier Briand.;Véronique Touche.;Sophie Colin.;Gemma Brufau.;Alberto Davalos.;Marleen Schonewille.;Fabiola Bovenga.;Véronique Carrière.;Jan Freark de Boer.;Camille Dugardin.;Béatrice Riveau.;Véronique Clavey.;Anne Tailleux.;Antonio Moschetta.;Miguel A Lasunción.;Albert K Groen.;Bart Staels.;Sophie Lestavel.
来源: Gastroenterology. 2016年150卷3期650-8页
Reducing postprandial triglyceridemia may be a promising strategy to lower the risk of cardiovascular disorders associated with obesity and type 2 diabetes. In enterocytes, scavenger receptor class B, type 1 (SR-B1, encoded by SCARB1) mediates lipid-micelle sensing to promote assembly and secretion of chylomicrons. The nuclear receptor subfamily 1, group H, members 2 and 3 (also known as liver X receptors [LXRs]) regulate genes involved in cholesterol and fatty acid metabolism. We aimed to determine whether intestinal LXRs regulate triglyceride absorption.
92. Depression and Somatization Are Associated With Increased Postprandial Symptoms in Patients With Irritable Bowel Syndrome.
作者: Lukas Van Oudenhove.;Hans Törnblom.;Stine Störsrud.;Jan Tack.;Magnus Simrén.
来源: Gastroenterology. 2016年150卷4期866-74页
Patients with irritable bowel syndrome (IBS) have increased postprandial symptom responses and more psychosocial morbidities than healthy individuals. However, the relationship between psychosocial status and postprandial symptom responses in patients with IBS is unclear. We investigated this relationship in a prospective study of patients with IBS.
94. Inhibition of Tumor Growth and Metastasis in Pancreatic Cancer Models by Interference With CD44v6 Signaling.
作者: Alexandra Matzke-Ogi.;Katharina Jannasch.;Marine Shatirishvili.;Beatrix Fuchs.;Sara Chiblak.;Jennifer Morton.;Bouchra Tawk.;Thomas Lindner.;Owen Sansom.;Frauke Alves.;Arne Warth.;Christian Schwager.;Walter Mier.;Jörg Kleeff.;Helmut Ponta.;Amir Abdollahi.;Véronique Orian-Rousseau.
来源: Gastroenterology. 2016年150卷2期513-25.e10页
Cancer cells with high metastatic potential and stem cell-like characteristics express the cell surface marker CD44. CD44 isoforms that include the v6 exon are co-receptors for the receptor tyrosine kinases MET and Vascular Endothelial Growth factor Receptor-2 (VEGFR-2). We studied CD44v6 signaling in several pancreatic cancer cell lines, and its role in tumor growth and metastasis in several models of pancreatic cancer.
97. Evaluation of a clinical risk index for advanced colorectal neoplasia among a North American population of screening age.
作者: Arlinda Ruco.;David Stock.;Robert J Hilsden.;S Elizabeth McGregor.;Lawrence F Paszat.;Refik Saskin.;Linda Rabeneck.
来源: BMC Gastroenterol. 2015年15卷162页
A clinical risk index employing age, sex, family history of colorectal cancer (CRC), smoking history and body mass index (BMI) may be useful for prioritizing screening with colonoscopy. The aim of this study was to conduct an external evaluation of a previously published risk index for advanced neoplasia (AN) in a large, well-characterized cohort.
98. Perceived food intolerance and irritable bowel syndrome in a population 3 years after a giardiasis-outbreak: a historical cohort study.
作者: Sverre Litleskare.;Knut-Arne Wensaas.;Geir Egil Eide.;Kurt Hanevik.;Gudrun Elise Kahrs.;Nina Langeland.;Guri Rortveit.
来源: BMC Gastroenterol. 2015年15卷164页
Studies have shown an increased prevalence of irritable bowel syndrome (IBS) after acute gastroenteritis. Food as a precipitating and perpetuating factor in IBS has gained recent interest, but food intolerance following gastroenteritis is less investigated. The aims of this study were firstly, to compare perceived food intolerance in a group previously exposed to Giardia lamblia with a control group; secondly, to explore the relation with IBS status; and thirdly, to investigate associations with content of fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) in foods reported.
99. An open-label prospective randomized multicenter study of intensive versus weekly granulocyte and monocyte apheresis in active crohn's disease.
作者: Naoki Yoshimura.;Yoko Yokoyama.;Katsuyoshi Matsuoka.;Hiroki Takahashi.;Ryuichi Iwakiri.;Takayuki Yamamoto.;Tomoo Nakagawa.;Takumi Fukuchi.;Satoshi Motoya.;Reiko Kunisaki.;Shingo Kato.;Fumihito Hirai.;Yoh Ishiguro.;Satoshi Tanida.;Sakiko Hiraoka.;Keiichi Mitsuyama.;Shunji Ishihara.;Shinji Tanaka.;Michiro Otaka.;Taro Osada.;Takashi Kagaya.;Yasuo Suzuki.;Hiroshi Nakase.;Hiroyuki Hanai.;Kenji Watanabe.;Nobuhito Kashiwagi.;Toshifumi Hibi.
来源: BMC Gastroenterol. 2015年15卷163页
Granulocyte and monocyte adsorptive apheresis (GMA) has shown efficacy in patients with active Crohn's disease (CD). However, with routine weekly therapy, it may take several weeks to achieve remission. This study was performed to assess clinical efficacy and safety of intensive GMA in patients with active CD.
100. American Gastroenterological Association Institute Guideline on the Medical Management of Microscopic Colitis.
作者: Geoffrey C Nguyen.;Walter E Smalley.;Santhi Swaroop Vege.;Alonso Carrasco-Labra.; .
来源: Gastroenterology. 2016年150卷1期242-6; quiz e17-8页 |