"N Engl J Med"[journal] 检索结果

81. Outcomes of Procedures Performed by Attending Surgeons after Night Work.

作者: Anand Govindarajan.;David R Urbach.;Nancy N Baxter.
来源: N Engl J Med. 2015年373卷24期2384页

82. Community-Acquired Pneumonia Requiring Hospitalization.

作者: Suheyla Kaya.;Ozge Telci Caklili.;Aytekin Oguz.
来源: N Engl J Med. 2015年373卷24期2381页

83. Community-Acquired Pneumonia Requiring Hospitalization.

作者: Daniel M Musher.;Michael S Abers.
来源: N Engl J Med. 2015年373卷24期2381页

84. Community-Acquired Pneumonia Requiring Hospitalization.

作者: Pedro J Marcos.;Marcos I Restrepo.;Antonio Anzueto.
来源: N Engl J Med. 2015年373卷24期2380-1页

85. Community-Acquired Pneumonia Requiring Hospitalization.

作者: Joseph P Mizgerd.
来源: N Engl J Med. 2015年373卷24期2380页

86. Community-Acquired Pneumonia Requiring Hospitalization.

作者: Seema Jain.;Wesley H Self.;Richard G Wunderink.; .
来源: N Engl J Med. 2015年373卷24期2382页

87. The Immune Response--Learning to Leave Well Enough Alone.

作者: James T Rosenbaum.
来源: N Engl J Med. 2015年373卷24期2378-9页

88. Scabies and Global Control of Neglected Tropical Diseases.

作者: Bart J Currie.
来源: N Engl J Med. 2015年373卷24期2371-2页

89. CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 38-2015. A 21-Year-Old Man with Fatigue and Weight Loss.

作者: J Carl Pallais.;Micheal McInnis.;Philip J Saylor.;Roseann I Wu.
来源: N Engl J Med. 2015年373卷24期2358-69页

90. IMAGES IN CLINICAL MEDICINE. Squamous-Cell Carcinoma of the Nail Bed.

作者: Amir Feily.
来源: N Engl J Med. 2015年373卷24期2357页

91. CLINICAL PRACTICE. Thyroid Nodules.

作者: Kenneth D Burman.;Leonard Wartofsky.
来源: N Engl J Med. 2015年373卷24期2347-56页

92. Endobronchial Valves for Emphysema without Interlobar Collateral Ventilation.

作者: Karin Klooster.;Nick H T ten Hacken.;Jorine E Hartman.;Huib A M Kerstjens.;Eva M van Rikxoort.;Dirk-Jan Slebos.
来源: N Engl J Med. 2015年373卷24期2325-35页

Bronchoscopic lung-volume reduction with the use of one-way endobronchial valves is a potential treatment for patients with severe emphysema. To date, the benefits have been modest but have been hypothesized to be much larger in patients without interlobar collateral ventilation than in those with collateral ventilation.

93. Mass Drug Administration for Scabies Control in a Population with Endemic Disease.

作者: Lucia Romani.;Margot J Whitfeld.;Josefa Koroivueta.;Mike Kama.;Handan Wand.;Lisi Tikoduadua.;Meciusela Tuicakau.;Aminiasi Koroi.;Ross Andrews.;John M Kaldor.;Andrew C Steer.
来源: N Engl J Med. 2015年373卷24期2305-13页

Scabies is an underrecognized cause of illness in many developing countries. It is associated with impetigo, which can lead to serious systemic complications. We conducted a trial of mass drug administration for scabies control in Fiji.

94. My Life as a (Fake) Patient.

作者: Ellen Aronofsky Cole.
来源: N Engl J Med. 2015年373卷24期2302-3页

95. Biallelic NTHL1 Mutations in a Woman with Multiple Primary Tumors.

来源: N Engl J Med. 2015年373卷25期e33页

96. FDA Approval of Flibanserin--Treating Hypoactive Sexual Desire Disorder.

作者: Hylton V Joffe.;Christina Chang.;Catherine Sewell.;Olivia Easley.;Christine Nguyen.;Somya Dunn.;Kimberly Lehrfeld.;LaiMing Lee.;Myong-Jin Kim.;Ashley F Slagle.;Julie Beitz.
来源: N Engl J Med. 2016年374卷2期101-4页

97. Acquired Resistance to Bedaquiline and Delamanid in Therapy for Tuberculosis.

来源: N Engl J Med. 2015年373卷25期e29页

98. A Multinational Trial of Prasugrel for Sickle Cell Vaso-Occlusive Events.

作者: Matthew M Heeney.;Carolyn C Hoppe.;Miguel R Abboud.;Baba Inusa.;Julie Kanter.;Bernhards Ogutu.;Patricia B Brown.;Lori E Heath.;Joseph A Jakubowski.;Chunmei Zhou.;Dmitry Zamoryakhin.;Tsiri Agbenyega.;Raffaella Colombatti.;Hoda M Hassab.;Videlis N Nduba.;Janet N Oyieko.;Nancy Robitaille.;Catherine I Segbefia.;David C Rees.; .
来源: N Engl J Med. 2016年374卷7期625-35页

Sickle cell anemia is an inherited blood disorder that is characterized by painful vaso-occlusive crises, for which there are few treatment options. Platelets mediate intercellular adhesion and thrombosis during vaso-occlusion in sickle cell anemia, which suggests a role for antiplatelet agents in modifying disease events.

99. Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia.

作者: John C Byrd.;Bonnie Harrington.;Susan O'Brien.;Jeffrey A Jones.;Anna Schuh.;Steve Devereux.;Jorge Chaves.;William G Wierda.;Farrukh T Awan.;Jennifer R Brown.;Peter Hillmen.;Deborah M Stephens.;Paolo Ghia.;Jacqueline C Barrientos.;John M Pagel.;Jennifer Woyach.;Dave Johnson.;Jane Huang.;Xiaolin Wang.;Allard Kaptein.;Brian J Lannutti.;Todd Covey.;Maria Fardis.;Jesse McGreivy.;Ahmed Hamdy.;Wayne Rothbaum.;Raquel Izumi.;Thomas G Diacovo.;Amy J Johnson.;Richard R Furman.
来源: N Engl J Med. 2016年374卷4期323-32页

Irreversible inhibition of Bruton's tyrosine kinase (BTK) by ibrutinib represents an important therapeutic advance for the treatment of chronic lymphocytic leukemia (CLL). However, ibrutinib also irreversibly inhibits alternative kinase targets, which potentially compromises its therapeutic index. Acalabrutinib (ACP-196) is a more selective, irreversible BTK inhibitor that is specifically designed to improve on the safety and efficacy of first-generation BTK inhibitors.

100. Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia.

作者: Andrew W Roberts.;Matthew S Davids.;John M Pagel.;Brad S Kahl.;Soham D Puvvada.;John F Gerecitano.;Thomas J Kipps.;Mary Ann Anderson.;Jennifer R Brown.;Lori Gressick.;Shekman Wong.;Martin Dunbar.;Ming Zhu.;Monali B Desai.;Elisa Cerri.;Sari Heitner Enschede.;Rod A Humerickhouse.;William G Wierda.;John F Seymour.
来源: N Engl J Med. 2016年374卷4期311-22页

New treatments have improved outcomes for patients with relapsed chronic lymphocytic leukemia (CLL), but complete remissions remain uncommon. Venetoclax has a distinct mechanism of action; it targets BCL2, a protein central to the survival of CLL cells.

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