8461. Analysis of p53 tumour suppressor gene somatic mutations in rheumatoid arthritis synovium.
作者: M Inazuka.;T Tahira.;T Horiuchi.;S Harashima.;T Sawabe.;M Kondo.;H Miyahara.;K Hayashi.
来源: Rheumatology (Oxford). 2000年39卷3期262-6页
In order to study the role of the p53 tumour suppressor gene in the proliferation of rheumatoid arthritis (RA) synovium, we analysed the mutation of p53 in the synovial fibroblast-like type B synoviocyte from RA patients.
8462. Rapid lupus autoantigen relocalization and reactive oxygen species accumulation following ultraviolet irradiation of human keratinocytes.
作者: W Lawley.;A Doherty.;S Denniss.;D Chauhan.;G Pruijn.;W J van Venrooij.;J Lunec.;K Herbert.
来源: Rheumatology (Oxford). 2000年39卷3期253-61页
In vitro treatment with ultraviolet B (UVB) induces relocalization of lupus autoantigens to the cell surface. We have addressed the relationship between autoantigen relocalization, accumulation of intracellular reactive oxygen species (ROS) and the induction of apoptosis following UVA and UVB exposure.
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