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8162. Autoimmune hepatitis and systemic sclerosis: a new overlap syndrome?
作者: I Marie.;H Levesque.;J L Tranvouez.;A François.;G Riachi.;N Cailleux.;H Courtois.
来源: Rheumatology (Oxford). 2001年40卷1期102-6页
We report the cases of two patients with the complete CREST variant (calcinosis, Raynaud's phenomenon, oesophageal dysmotility, sclerodactyly, telangiectasia) of systemic sclerosis (SSc) who developed autoimmune hepatitis.
8163. Risk factors for persistent chronic widespread pain: a community-based study.
Chronic widespread pain is the cardinal clinical feature of the fibromyalgia syndrome, which, in the majority of clinic patients, is persistent. By contrast, in community-derived patients, pain is persistent in only half of the affected individuals, particularly those with psychological distress. Whether such distress is a consequence of the pain or a manifestation of a wider process of somatization which is associated with the persistence of pain is unclear.
8164. Incomplete lupus erythematosus: results of a multicentre study under the supervision of the EULAR Standing Committee on International Clinical Studies Including Therapeutic Trials (ESCISIT).
作者: A J Swaak.;H van de Brink.;R J Smeenk.;K Manger.;J R Kalden.;S Tosi.;A Marchesoni.;Z Domljan.;B Rozman.;D Logar.;G Pokorny.;L Kovacs.;A Kovacs.;P G Vlachoyiannopoulos.;H M Moutsopoulos.;H Chwalinska-Sadowska.;B Dratwianka.;E Kiss.;N Cikes.;B Anic.;M Schneider.;R Fischer.;S Bombardieri.;M Mosca.;W Graninger.;J S Smolen.; .
来源: Rheumatology (Oxford). 2001年40卷1期89-94页
Patients characterized with antinuclear antibodies (ANA) and disease symptoms related to one organ system can be described as having incomplete systemic lupus erythematosus (SLE). The aim of this multicentre study was to describe the outcome of these so-called incomplete SLE patients. Two aspects of the outcome were studied: (i) the disease course, defined by the presence or absence of clinical symptoms; and (ii) the number of patients that eventually developed full SLE.
8165. Pilot study of anti-thymocyte globulin plus mycophenolate mofetil in recent-onset diffuse scleroderma.
To assess the safety and efficacy of anti-thymocyte globulin (ATG) followed by mycophenolate mofetil (MMF) in the treatment of diffuse scleroderma.
8166. High concentrations of dexamethasone suppress the proliferation but not the differentiation or further maturation of human osteoblast precursors in vitro: relevance to glucocorticoid-induced osteoporosis.
作者: S Walsh.;G R Jordan.;C Jefferiss.;K Stewart.;J N Beresford.
来源: Rheumatology (Oxford). 2001年40卷1期74-83页
The use of glucocorticoids (GCs) in the treatment of RA is a frequent cause of bone loss. In vitro, however, this same class of steroids has been shown to promote the recruitment and/or maturation of primitive osteogenic precursors present in the colony forming unit-fibroblastic (CFU-F) fraction of human bone and marrow. In an effort to reconcile these conflicting observations, we investigated the effects of the synthetic GC dexamethasone (Dx) on parameters of growth and osteogenic differentiation in cultures of bone marrow stromal cells derived from a large cohort of adult human donors (n=30).
8167. Prevalence of large-joint osteoarthritis in Asian and Caucasian skeletal populations.
作者: K Inoue.;S Hukuda.;P Fardellon.;Z Q Yang.;M Nakai.;K Katayama.;T Ushiyama.;Y Saruhashi.;J Huang.;A Mayeda.;I Catteddu.;C Obry.
来源: Rheumatology (Oxford). 2001年40卷1期70-3页
To determine ethnic variations of large-joint osteoarthritis (OA) in past populations.
8168. The effects of treatment with interleukin-1 receptor antagonist on the inflamed synovial membrane in rheumatoid arthritis.
作者: G Cunnane.;A Madigan.;E Murphy.;O FitzGerald.;B Bresnihan.
来源: Rheumatology (Oxford). 2001年40卷1期62-9页
To evaluate the effects of treatment with interleukin-1 receptor antagonist (IL-1Ra) on synovial tissue in rheumatoid arthritis (RA).
8169. Human granzyme B mediates cartilage proteoglycan degradation and is expressed at the invasive front of the synovium in rheumatoid arthritis.
作者: H K Ronday.;W H van der Laan.;P P Tak.;J A de Roos.;R A Bank.;J M TeKoppele.;C J Froelich.;C E Hack.;P C Hogendoorn.;F C Breedveld.;J H Verheijen.
来源: Rheumatology (Oxford). 2001年40卷1期55-61页
To investigate the cartilage-degrading capacity of granzyme B and the presence of granzyme B-positive cells at sites of erosion in the rheumatoid synovium.
8170. Evidence of association and linkage disequilibrium between a novel polymorphism in the transforming growth factor beta 1 gene and hip bone mineral density: a study of female twins.
作者: R W Keen.;H Snieder.;H Molloy.;J Daniels.;M Chiano.;F Gibson.;L Fairbairn.;P Smith.;A J MacGregor.;D Gewert.;T D Spector.
来源: Rheumatology (Oxford). 2001年40卷1期48-54页
Bone mineral density (BMD) in later life is a major determinant of osteoporotic fracture risk and has been shown to be under strong genetic influence. Transforming growth factor beta 1 (TGF-beta 1) is an important regulatory cytokine, is found in high concentrations in the bone matrix, and is a plausible candidate for the genetic regulation of BMD.
8171. Total costs and predictors of costs in patients with systemic lupus erythematosus.
作者: N Sutcliffe.;A E Clarke.;R Taylor.;C Frost.;D A Isenberg.
来源: Rheumatology (Oxford). 2001年40卷1期37-47页
To determine the annual direct, indirect and total costs and predictors of costs in patients with systemic lupus erythematosus (SLE).
8172. HLA class II gene polymorphisms in antiphospholipid syndrome: haplotype analysis in 83 Caucasoid patients.
作者: R Caliz.;T Atsumi.;E Kondeatis.;O Amengual.;M A Khamashta.;R W Vaughan.;J S Lanchbury.;G R Hughes.
来源: Rheumatology (Oxford). 2001年40卷1期31-6页
We investigated the association between HLA class II haplotypes and antiphospholipid syndrome (APS).
8173. A prospective 2-year study of 75 patients with adult-onset septic arthritis.
To assess the clinical features of septic arthritis and characterize therapeutic strategies and outcome in a prospective study of 75 patients selected by positive synovial fluid culture.
8174. Correlation between the immune responses to collagens type I, III, IV and V and Klebsiella pneumoniae in patients with Crohn's disease and ankylosing spondylitis.
作者: H Tiwana.;R S Natt.;R Benitez-Brito.;S Shah.;C Wilson.;S Bridger.;M Harbord.;M Sarner.;A Ebringer.
来源: Rheumatology (Oxford). 2001年40卷1期15-23页
Increased levels of collagen types I, III and V are found in strictures of patients with Crohn's disease (CD) compared with normal gut tissue. Type IV collagen is present in the basement membranes, basal lamina, retina and cornea. Elevated levels of antibody to Klebsiella pneumoniae are found in both active CD and active ankylosing spondylitis (AS) patients compared with healthy controls.
8175. On conducting burden-of-osteoporosis studies: a review of the core concepts and practical issues. A study carried out under the auspices of a WHO Collaborating Center.
Osteoporosis is a problem that is relevant to public health from the clinical, economic and social viewpoints. Except in a handful of industrialized countries, there is a considerable void in our knowledge of the magnitude of the problem. By exploring both the epidemiological and the economic impact of osteoporosis and the fractures associated with it in a particular country, studies of the 'burden of illness' (BOI) can fill that void. BOI analysis raises many questions at both the conceptual and the practical level. The purpose of this paper is to review the methodology underlying analyses of this type, to discuss its limitations and to provide a general format to improve their implementation in the field of osteoporosis. Investigators involved in BOI analysis should be very clear and explicit regarding the methods they adopt, so that studies in different countries can be interpreted and compared appropriately by interested parties.
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