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62. Budesonide Oral Suspension Improves Symptomatic, Endoscopic, and Histologic Parameters Compared With Placebo in Patients With Eosinophilic Esophagitis.
作者: Evan S Dellon.;David A Katzka.;Margaret H Collins.;Mohamed Hamdani.;Sandeep K Gupta.;Ikuo Hirano.; .
来源: Gastroenterology. 2017年152卷4期776-786.e5页
Pharmacologic treatment of eosinophilic esophagitis (EoE) is limited to off-label use of corticosteroids not optimized for esophageal delivery. We performed a randomized, controlled phase 2 trial to assess the ability of budesonide oral suspension (BOS), a novel muco-adherent topical steroid formulation, to reduce symptoms and esophageal eosinophilia in adolescents and adults with EoE.
66. Inhibitor of Apoptosis Protein-1 Regulates Tumor Necrosis Factor-Mediated Destruction of Intestinal Epithelial Cells.
作者: Thomas Grabinger.;Konstantin J Bode.;Janine Demgenski.;Carina Seitz.;M Eugenia Delgado.;Feodora Kostadinova.;Cindy Reinhold.;Nima Etemadi.;Sabine Wilhelm.;Matthias Schweinlin.;Kay Hänggi.;Janin Knop.;Christof Hauck.;Heike Walles.;John Silke.;Harald Wajant.;Ueli Nachbur.;Wong W Wei-Lynn.;Thomas Brunner.
来源: Gastroenterology. 2017年152卷4期867-879页
Tumor necrosis factor (TNF) is a cytokine that promotes inflammation and contributes to pathogenesis of inflammatory bowel diseases. Unlike other cells and tissues, intestinal epithelial cells undergo rapid cell death upon exposure to TNF, by unclear mechanisms. We investigated the roles of inhibitor of apoptosis proteins (IAPs) in the regulation of TNF-induced cell death in the intestinal epithelium of mice and intestinal organoids.
74. Sofosbuvir and Daclatasvir Anti-Viral Therapy Fails to Clear HEV Viremia and Restore Reactive T Cells in a HEV/HCV Co-Infected Liver Transplant Recipient.
作者: Mhairi C Donnelly.;Stuart N Imlach.;Florence Abravanel.;Sandeep Ramalingam.;Ingolfur Johannessen.;Juraj Petrik.;Alistair R Fraser.;John D M Campbell.;Peter Bramley.;Harry R Dalton.;Peter C Hayes.;Nassim Kamar.;Kenneth J Simpson.
来源: Gastroenterology. 2017年152卷1期300-301页 75. Patients with longstanding ulcerative colitis in remission do not have more irritable bowel syndrome-like symptoms than controls.
Irritable bowel syndrome (IBS) is more common in patients with ulcerative colitis (UC) than expected. The prevalence of IBS in patients with UC with longstanding disease is not known. We investigated the prevalence of IBS-like symptoms in patients with UC in remission and longstanding disease in comparison to control subjects.
76. Fusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear Factor-κB, and Up-regulating Expression of MicroRNA-21.
作者: Yongzhi Yang.;Wenhao Weng.;Junjie Peng.;Leiming Hong.;Lei Yang.;Yuji Toiyama.;Renyuan Gao.;Minfeng Liu.;Mingming Yin.;Cheng Pan.;Hao Li.;Bomin Guo.;Qingchao Zhu.;Qing Wei.;Mary-Pat Moyer.;Ping Wang.;Sanjun Cai.;Ajay Goel.;Huanlong Qin.;Yanlei Ma.
来源: Gastroenterology. 2017年152卷4期851-866.e24页
Nearly 20% of the global cancer burden can be linked to infectious agents. Fusobacterium nucleatum promotes tumor formation by epithelial cells via unclear mechanisms. We aimed to identify microRNAs (miRNAs) induced by F nucleatum and evaluate their ability to promote colorectal carcinogenesis in mice.
77. Efficacy of Sterile Fecal Filtrate Transfer for Treating Patients With Clostridium difficile Infection.
作者: Stephan J Ott.;Georg H Waetzig.;Ateequr Rehman.;Jacqueline Moltzau-Anderson.;Richa Bharti.;Juris A Grasis.;Liam Cassidy.;Andreas Tholey.;Helmut Fickenscher.;Dirk Seegert.;Philip Rosenstiel.;Stefan Schreiber.
来源: Gastroenterology. 2017年152卷4期799-811.e7页
Fecal microbiota transplantation (FMT) is a highly effective therapy for recurrent Clostridium difficile infection (CDI). However, transferring undefined living bacteria entails uncontrollable risks for infectious and metabolic or malignant diseases, particularly in immunocompromised patients. We investigated whether sterile fecal filtrates (containing bacterial debris, proteins, antimicrobial compounds, metabolic products, and oligonucleotides/DNA), rather than intact microorganisms, are effective in patients with CDI.
78. Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice.
作者: Han-Byul Kim.;Minchul Kim.;Young-Soo Park.;Intae Park.;Tackhoon Kim.;Sung-Yeun Yang.;Charles J Cho.;DaeHee Hwang.;Jin-Hak Jung.;Sanford D Markowitz.;Sung Wook Hwang.;Suk-Kyun Yang.;Dae-Sik Lim.;Seung-Jae Myung.
来源: Gastroenterology. 2017年152卷3期616-630页
Prostaglandin E2 (PGE2) is mediator of inflammation that regulates tissue regeneration, but its continual activation has been associated with carcinogenesis. Little is known about factors in the PGE2 signaling pathway that contribute to tumor formation. We investigated whether yes-associated protein 1 (YAP1), a transcriptional co-activator in the Hippo signaling pathway, mediates PGE2 function.
79. No Difference Between Latiglutenase and Placebo in Reducing Villous Atrophy or Improving Symptoms in Patients With Symptomatic Celiac Disease.
作者: Joseph A Murray.;Ciarán P Kelly.;Peter H R Green.;Annette Marcantonio.;Tsung-Teh Wu.;Markku Mäki.;Daniel C Adelman.; .
来源: Gastroenterology. 2017年152卷4期787-798.e2页
Gluten ingestion leads to symptoms and small intestinal mucosal injury in patients with celiac disease. The only option is the strict lifelong exclusion of dietary gluten, which is difficult to accomplish. Many patients following a gluten-free diet continue to have symptoms and have small intestinal mucosal injury. Nondietary therapies are needed. We performed a phase 2 study of the ability of latiglutenase, an orally administered mixture of 2 recombinant gluten-targeting proteases, to reduce mucosal morphometric measures in biopsy specimens from patients with celiac disease.
80. Liver abscess and bacteremia caused by lactobacillus: role of probiotics? Case report and review of the literature.
作者: Muhammed Sherid.;Salih Samo.;Samian Sulaiman.;Husein Husein.;Humberto Sifuentes.;Subbaramiah Sridhar.
来源: BMC Gastroenterol. 2016年16卷1期138页
Lactobacilli are non-spore forming, lactic acid producing, gram-positive rods. They are a part of the normal gastrointestinal and genitourinary microbiota and have rarely been reported to be the cause of infections. Lactobacilli species are considered non-pathogenic organisms and have been used as probiotics to prevent antibiotic associated diarrhea. There are sporadic reported cases of infections related to lactobacilli containing probiotics.
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