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7786. Activated caspase 3 and cleaved poly(ADP-ribose)polymerase in salivary epithelium suggest a pathogenetic mechanism for Sjögren's syndrome.
作者: F Jimenez.;S Aiba-Masago.;I Al Hashimi.;N Vela-Roch.;G Fernandes.;C-K Yeh.;N Talal.;H Dang.
来源: Rheumatology (Oxford). 2002年41卷3期338-42页
Apoptosis is an organized energy-dependent process of cellular self-destruction carried out by proteolytic enzymes such as the caspases. These enzymes may play a role in epithelial cell apoptosis in Sjögren's syndrome (SS). A classical caspase substrate is poly(ADP-ribose)polymerase (PARP), a DNA repair enzyme. To elucidate the molecular mechanisms responsible for salivary gland dysfunction in SS, we studied the expression of caspase and PARP in SS salivary gland biopsies.
7787. The role of TNF-alpha in the pathogenesis of inflammation and joint destruction in rheumatoid arthritis (RA): a study using a human RA/SCID mouse chimera.
作者: H Matsuno.;K Yudoh.;R Katayama.;F Nakazawa.;M Uzuki.;T Sawai.;T Yonezawa.;Y Saeki.;G S Panayi.;C Pitzalis.;T Kimura.
来源: Rheumatology (Oxford). 2002年41卷3期329-37页
In order to elucidate which cytokine preferentially stimulates the synovium in patients with rheumatoid arthritis (RA), we investigated the roles of tumour necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) using SCID mice engrafted with human RA tissue (SCID-HuRAg).
7788. Digital vascular response to topical glyceryl trinitrate, as measured by laser Doppler imaging, in primary Raynaud's phenomenon and systemic sclerosis.
作者: M E Anderson.;T L Moore.;S Hollis.;M I V Jayson.;T A King.;A L Herrick.
来源: Rheumatology (Oxford). 2002年41卷3期324-8页
To investigate digital microvascular responses to topical glyceryl trinitrate (GTN) in patients with primary Raynaud's phenomenon (PRP), limited cutaneous systemic sclerosis (LCSSc) and healthy control subjects, using laser Doppler imaging.
7789. Dendritic cells in rheumatoid synovial membrane after total removal of the hyaline articular cartilage.
作者: T F Li.;J Mandelin.;M Hukkanen.;J Lassus.;J Sandelin.;S Santavirta.;I Virtanen.;Y T Konttinen.
来源: Rheumatology (Oxford). 2002年41卷3期319-23页
To investigate the effect of total removal of the hyaline articular cartilage on dendritic cells in synovial membrane in rheumatoid arthritis (RA) or ankylosing spondylitis (AS).
7790. Campylobacter-triggered reactive arthritis: a population-based study.
作者: T Hannu.;L Mattila.;H Rautelin.;P Pelkonen.;P Lahdenne.;A Siitonen.;M Leirisalo-Repo.
来源: Rheumatology (Oxford). 2002年41卷3期312-8页
To study the incidence and clinical picture of Campylobacter-associated reactive arthritis (ReA) and other reactive musculoskeletal symptoms in the population.
7791. The contribution of HLA-DQB1 coding and QBP promoter alleles to anti-Ro alone autoantibody response in systemic lupus erythematosus.
作者: D Logar.;B Vidan-Jeras.;V Dolzan.;B Bozic.;T Kveder.
来源: Rheumatology (Oxford). 2002年41卷3期305-11页
To analyse the influence of HLA-DR, DQ and corresponding DQA1 and DQB1 promoter alleles (QAP and QBP) on the anti-Ro alone autoantibody response in systemic lupus erythematosus (SLE).
7792. Sjögren's syndrome in an out-patient clinic: classification of patients according to the preliminary European criteria and the proposed modified European criteria.
To investigate whether out-patients with a clinical diagnosis of Sjögren's syndrome (SS) satisfied current preliminary European criteria for SS, and to determine the proportion of patients who satisfied the proposed modified European criteria for SS and thus had indication of an autoimmune process.
7793. Characteristics and outcome of 49 patients with symptomatic cryoglobulinaemia.
作者: V Rieu.;P Cohen.;M-H André.;L Mouthon.;P Godmer.;B Jarrousse.;F Lhote.;F Ferrière.;P Dény.;P Buchet.;L Guillevin.
来源: Rheumatology (Oxford). 2002年41卷3期290-300页
To describe a population of patients with symptomatic cryoglobulinaemia, comparing manifestations and outcome as a function of hepatitis C virus (HCV) status.
7794. Bioavailable testosterone in men with rheumatoid arthritis-high frequency of hypogonadism.
To study bioavailable testosterone (T) in men with rheumatoid arthritis (RA) by determining non-sex hormone-binding globulin (SHBG)-bound T (NST) under standardized conditions and to investigate if NST is related to disease variables.
7795. A randomized, double-blind, placebo-controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the knee.
A randomized, placebo-controlled, double-blind trial of the relative effectiveness of glucosamine sulphate and placebo in managing pain in osteoarthritis (OA) of the knee.
7796. Adjuvant treatment of patients with antineutrophil cytoplasmic antibody-associated vasculitis with vitamins E and C reduces superoxide production by neutrophils.
Neutrophils when activated generate a respiratory burst which has been implicated in the pathogenesis of primary systemic vasculitis. Neutrophils from patients with vasculitis have a greater respiratory burst than normal healthy donors. The aim of this study was to assess the effects of antioxidant treatment (vitamins E and C) on the generation of a respiratory burst from neutrophils isolated from patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis.
7797. Computerized information-gathering in specialist rheumatology clinics: an initial evaluation of an electronic version of the Short Form 36.
作者: A S Wilson.;G D Kitas.;D M Carruthers.;C Reay.;J Skan.;S Harris.;G J Treharne.;S P Young.;P A Bacon.
来源: Rheumatology (Oxford). 2002年41卷3期268-73页
Longitudinal outcome data are important for research and are becoming part of routine clinical practice. We assessed an initial version of an electronic Short Form 36 (SF-36), a well-established health assessment questionnaire, in comparison with standard paper forms, in two specialist rheumatology clinics.
7798. Investigation of the chronic pulmonary effects of low-dose oral methotrexate in patients with rheumatoid arthritis: a prospective study incorporating HRCT scanning and pulmonary function tests.
作者: J K Dawson.;D R Graham.;J Desmond.;H E Fewins.;M P Lynch.
来源: Rheumatology (Oxford). 2002年41卷3期262-7页
Methotrexate has a well-recognized side-effect of acute hypersensitivity pneumonitis. There is concern about whether chronic pulmonary toxicity can occur with methotrexate treatment. Our objective was to compare chest high-resolution computed tomography (HRCT) findings and serial pulmonary function tests in rheumatoid arthritis (RA) patients on methotrexate with findings for a control group of patients with RA who were not being treated with methotrexate.
7799. Unwillingness of rheumatoid arthritis patients to risk adverse effects.
To evaluate patient willingness to accept the risk of adverse effects (AEs) commonly associated with arthritis medications.
7800. Erosions in inflammatory polyarthritis are symmetrical regardless of rheumatoid factor status: results from a primary care-based inception cohort of patients.
作者: M Bukhari.;M Lunt.;B J Harrison.;D G I Scott.;D P M Symmons.;A J Silman.
来源: Rheumatology (Oxford). 2002年41卷3期246-52页
Symmetry is considered an important criterion for the differentiation of rheumatoid arthritis (RA) from other forms of inflammatory polyarthritis (IP), particularly those that are seronegative. Because of the inclusion of symmetry in the diagnostic and classification process, however, its true occurrence in RA cannot be assessed. As a surrogate, peripheral inflammatory arthropathies associated with rheumatoid factor production may be more likely to be symmetrical. We examined the degree of symmetry of erosions in an unselected cohort of patients with IP and tested the hypothesis that the presence of rheumatoid factor (RF) is associated with greater symmetry.
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