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7481. Hydroxypyridinium collagen crosslinks in serum, urine, synovial fluid and synovial tissue in patients with rheumatoid arthritis compared with osteoarthritis.
作者: J Kaufmann.;A Mueller.;A Voigt.;H D Carl.;A Gursche.;J Zacher.;G Stein.;G Hein.
来源: Rheumatology (Oxford). 2003年42卷2期314-20页
To investigate the relationship between inflammation markers and content of pyridinium crosslinks in hydrolysates of synovial tissue and to specify the significance of urinary excreted pyridinoline, released primarily from collagen I and II of bone and cartilage, and deoxypyridinoline released especially from collagen I of bone and dentin, dependent on disease activity in rheumatoid arthritis (RA).
7482. The -308 polymorphism in the tumour necrosis factor (TNF) gene promoter region and ex vivo lipopolysaccharide-induced TNF expression and cytotoxic activity in Chilean patients with rheumatoid arthritis.
作者: J Cuenca.;M Cuchacovich.;C Pérez.;L Ferreira.;A Aguirre.;I Schiattino.;L Soto.;A Cruzat.;F Salazar-Onfray.;J C Aguillón.
来源: Rheumatology (Oxford). 2003年42卷2期308-13页
To investigate the association of the -308 polymorphism in the promoter region of the tumour necrosis factor (TNF) gene with susceptibility to the development of RA. We also explored the expression and cytotoxicity of TNF in relation to the -308 polymorphism.
7483. Development of rheumatoid arthritis is not associated with two polymorphisms in the Crohn's disease gene CARD15.
作者: S Steer.;S A Fisher.;M Fife.;A Cuthbert.;J Newton.;P Wordsworth.;C M Lewis.;C G Mathew.;J S Lanchbury.
来源: Rheumatology (Oxford). 2003年42卷2期304-7页
It has been proposed that genetic susceptibility loci for rheumatoid arthritis (RA) may be shared with other autoimmune/inflammatory diseases. Recently, common variation in the CARD15 (NOD2) gene on chromosome 16q12 has been associated with Crohn's disease (CD) in several independent populations. CARD15 is an excellent functional and positional candidate gene for RA.
7484. Urinary levels of creatine and other metabolites in the assessment of polymyositis and dermatomyositis.
作者: Y-L Chung.;W S Wassif.;J D Bell.;M Hurley.;D L Scott.
来源: Rheumatology (Oxford). 2003年42卷2期298-303页
A simple and reliable method is needed to assess disease activity and monitor the efficacy of therapy in polymyositis (PM) and dermatomyositis (DM). This study used in vitro proton ((1)H) magnetic resonance spectroscopy (MRS) to explore whether excretion of urinary metabolites can be used as a reliable marker of disease in PM and DM patients.
7485. Rheumatoid arthritis and macrovascular disease.
作者: J K Alkaabi.;M Ho.;R Levison.;T Pullar.;J J F Belch.
来源: Rheumatology (Oxford). 2003年42卷2期292-7页
To measure the extent of subclinical atherosclerosis in patients with rheumatoid arthritis (RA) compared with controls, and to evaluate any potential vascular risk factors.
7486. Suicides in persons suffering from rheumatoid arthritis.
作者: M Timonen.;K Viilo.;H Hakko.;T Särkioja.;M Ylikulju.;V B Meyer-Rochow.;E Väisänen.;P Räsänen.
来源: Rheumatology (Oxford). 2003年42卷2期287-91页
To assess the demographic and psychosocial profiles of patients with rheumatoid arthritis (RA) who committed suicide. Two control groups were used: osteoarthritis (OA) and suicide victims with neither RA nor OA.
7487. Effects of rheumatoid arthritis on sexual activity and relationships.
The primary aim of this research was to assess patients' perceptions of the effects of rheumatoid arthritis (RA) on their sexual relationship and sexual activity, the causes of any difficulties and who they would turn to for help.
7488. Association of damage with autoantibody profile, age, race, sex and disease duration in systemic lupus erythematosus.
作者: C-S Yee.;H Hussein.;J Skan.;S Bowman.;D Situnayake.;C Gordon.
来源: Rheumatology (Oxford). 2003年42卷2期276-9页
To determine if there is any association between autoantibody profile and damage in a cohort of patients with systemic lupus erythematosus (SLE).
7489. Predictors of radiological progression and changes in hand bone density in early rheumatoid arthritis.
作者: E Berglin.;R Lorentzon.;L Nordmark.;B Nilsson-Sojka.;S Rantapää Dahlqvist.
来源: Rheumatology (Oxford). 2003年42卷2期268-75页
To identify predictors for radiological and functional outcome and bone loss in the hands in early rheumatoid arthritis (RA) during the first 2 yr of disease and to study the relationship between these variables.
7491. Factors affecting knee cartilage volume in healthy men.
作者: F M Cicuttini.;A Wluka.;M Bailey.;R O'Sullivan.;C Poon.;S Yeung.;P R Ebeling.
来源: Rheumatology (Oxford). 2003年42卷2期258-62页
To understand the factors that influence joint cartilage in health and disease as they are important for the prevention and management of osteoarthritis.
7492. A simplified disease activity index for rheumatoid arthritis for use in clinical practice.
作者: J S Smolen.;F C Breedveld.;M H Schiff.;J R Kalden.;P Emery.;G Eberl.;P L van Riel.;P Tugwell.
来源: Rheumatology (Oxford). 2003年42卷2期244-57页
The objective of this study was to verify the usefulness of a simple disease activity index (SDAI) for rheumatoid arthritis (RA).
7493. Plasma plasmin-alpha2-plasmin inhibitor complex levels are increased in systemic sclerosis patients with pulmonary hypertension.
作者: M Jinnin.;H Ihn.;K Yamane.;Y Asano.;N Yazawa.;K Tamaki.
来源: Rheumatology (Oxford). 2003年42卷2期240-3页
To determine the frequency and clinical significance of plasma plasmin-alpha(2)-plasmin inhibitor complex (PIC) in patients with systemic sclerosis (SSc).
7494. Prospective study of anti-tumour necrosis factor receptor superfamily 1B fusion protein, and case study of anti-tumour necrosis factor receptor superfamily 1A fusion protein, in tumour necrosis factor receptor associated periodic syndrome (TRAPS): clinical and laboratory findings in a series of seven patients.
作者: E Drewe.;E M McDermott.;P T Powell.;J D Isaacs.;R J Powell.
来源: Rheumatology (Oxford). 2003年42卷2期235-9页
To assess the effects prospectively of tumour necrosis factor (TNF) receptor superfamily (TNFRSF) fusion proteins TNFRSF1B (etanercept) and TNFRSF1A (p55TNFr-Ig) in patients with TNF receptor associated periodic syndrome (TRAPS).
7495. Prevalence, patterns of disease and outcome in patients with systemic lupus erythematosus who develop severe haematological problems.
To evaluate the prevalence of major haemolytic disease-severe autoimmune haemolytic anaemia and severe thrombocytopenia-and to assess when these features develop. We also sought to analyse the clinical and serological outcomes of patients with haemolytic anaemia and thrombocytopenia with systemic lupus erythematosus (SLE) as compared with patients without these cytopenias.
7496. Prevalence of antineutrophil cytoplasmic autoantibodies in patients with tuberculosis.
作者: L F Flores-Suárez.;J Cabiedes.;A R Villa.;F J van der Woude.;J Alcocer-Varela.
来源: Rheumatology (Oxford). 2003年42卷2期223-9页
To determine the prevalence of antineutrophil cytoplasmic autoantibodies (ANCA) in sera of patients with tuberculosis compared with healthy control subjects and a group of patients with atopic asthma.
7497. Pathological lymphocyte activation by defective clearance of self-ligands in systemic lupus erythematosus.
Systemic lupus erythematosus (SLE) is one of the autoimmune diseases extensively studied by immunologists and physicians. The main focus regarding SLE pathophysiology has been placed on abnormal cell surface receptor function on lymphocytes. However, recent studies have revealed that defective clearance of apoptotic cells causes self-antigen accumulation, which could trigger the activation of autoreactive lymphocytes. Thus, here we review current findings about the association of the defective clearance of autoantigens and SLE, focusing on mutations in the DNase I locus and their relationship to SLE.
7498. Central nervous system involvement in the antiphospholipid (Hughes) syndrome.
作者: G Sanna.;M L Bertolaccini.;M J Cuadrado.;M A Khamashta.;G R V Hughes.
来源: Rheumatology (Oxford). 2003年42卷2期200-13页
The antiphospholipid (Hughes) syndrome (APS) is characterized by arterial and/or venous thrombosis and pregnancy morbidity in the presence of anticardiolipin antibodies and/or lupus anticoagulant. APS can occur either as a primary disorder or secondary to a connective tissue disease, most frequently systemic lupus erythematosus. Central nervous system (CNS) involvement is one of the most prominent clinical manifestations of APS, and includes arterial and venous thrombotic events, psychiatric features and a variety of other non-thrombotic neurological syndromes. In this review we focus on the common and some of the less common CNS manifestations that have been reported in association with antiphospholipid antibodies.
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