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7421. The three most common CARD15 mutations associated with Crohn's disease and the chromosome 16 susceptibility locus for systemic lupus erythematosus.
作者: I Ferreiros-Vidal.;J Garcia-Meijide.;P Carreira.;F Barros.;A Carracedo.;J J Gomez-Reino.;A Gonzalez.
来源: Rheumatology (Oxford). 2003年42卷4期570-4页
To test if the three most common mutations contributing to Crohn's disease on the CARD15/NOD2 gene could contribute also to genetic susceptibility to systemic lupus erythematosus (SLE), which has been found to be linked to the region of chromosome 16q13 where the CARD15 gene is located.
7422. Response of peripheral blood mononuclear cells from lupus patients to stimulation by CpG oligodeoxynucleotides.
作者: R A Zeuner.;D M Klinman.;G Illei.;C Yarboro.;K J Ishii.;M Gursel.;D Verthelyi.
来源: Rheumatology (Oxford). 2003年42卷4期563-9页
Increased levels of hypomethylated CpG-containing DNA in sera from patients with systemic lupus erythematosus (SLE) may contribute to the initiation and/or perpetuation of the disease. This study characterizes the in vitro response of peripheral blood mononuclear cells (PBMC) from SLE patients to CpG DNA.
7423. Prospective analysis of the impact of HLA-DR and -DQ on joint destruction in recent-onset rheumatoid arthritis.
作者: U Wagner.;S Kaltenhäuser.;M Pierer.;W Seidel.;M Tröltzsch.;H Häntzschel.;J R Kalden.;R Wassmuth.
来源: Rheumatology (Oxford). 2003年42卷4期553-62页
To evaluate the differential impact of HLA-DR and -DQ on the progression of erosive disease in the clinical course of early rheumatoid arthritis (RA).
7424. The epidemiology of biopsy-positive giant cell arteritis: special reference to changes in the age of the population.
作者: C Nordborg.;H Johansson.;V Petursdottir.;E Nordborg.
来源: Rheumatology (Oxford). 2003年42卷4期549-52页
The incidence of giant cell arteritis (GCA) increases with age. The aim of the present study was to investigate whether the increasing incidence of biopsy-proven GCA in Göteborg, Sweden, could be explained in terms of a change in the age composition of the general population.
7425. Influence of therapy with chimeric monoclonal tumour necrosis factor-alpha antibodies on intracellular cytokine profiles of T lymphocytes and monocytes in rheumatoid arthritis patients.
作者: A J Schuerwegh.;J F Van Offel.;W J Stevens.;C H Bridts.;L S De Clerck.
来源: Rheumatology (Oxford). 2003年42卷4期541-8页
It has been shown that T lymphocytes and monocytes/macrophages, producing pro-inflammatory cytokines, play a pivotal role in the pathophysiology of rheumatoid arthritis (RA). In recent placebo-controlled double-blind randomized studies, chimeric (human/mouse) tumour necrosis factor-alpha (TNFalpha) antibodies (cA2) proved to be very effective in improving clinical disease activity and reducing inflammatory parameters in RA.
7426. The association of antinuclear antibodies with organ involvement and survival in systemic sclerosis.
作者: R Hesselstrand.;A Scheja.;G Q Shen.;A Wiik.;A Akesson.
来源: Rheumatology (Oxford). 2003年42卷4期534-40页
To study the frequency and specificity of antinuclear antibodies (ANA) and their association with internal organ involvement and survival in systemic sclerosis (SSc).
7427. FcgammaRIIIA-158V and rheumatoid arthritis: a confirmation study.
作者: A W Morgan.;V H Keyte.;S J Babbage.;J I Robinson.;F Ponchel.;J H Barrett.;B B Bhakta.;S J Bingham.;M H Buch.;P G Conaghan.;A Gough.;M Green.;C A Lawson.;C T Pease.;A F Markham.;W E R Ollier.;P Emery.;J Worthington.;J D Isaacs.
来源: Rheumatology (Oxford). 2003年42卷4期528-33页
To develop a robust assay for genotyping the FcgammaRIIIA-158V/F polymorphism and to confirm the putative association between the FcgammaRIIIA-158V allele and rheumatoid arthritis (RA).
7428. Elevated levels of synovial fluid antibodies reactive with the small proteoglycans biglycan and decorin in patients with rheumatoid arthritis or other joint diseases.
作者: A Polgár.;A Falus.;E Koó.;I Ujfalussy.;M Seszták.;I Szuts.;K Konrád.;L Hodinka.;E Bene.;Gy Mészáros.;Zs Ortutay.;E Farkas.;A Paksy.;E I Buzás.
来源: Rheumatology (Oxford). 2003年42卷4期522-7页
To determine whether patients with rheumatoid arthritis (RA) express humoral immunity to the small proteoglycans biglycan and decorin and to compare the response to that of patients suffering from other joint diseases.
7429. Population requirement for primary knee replacement surgery: a cross-sectional study.
作者: P Jüni.;P Dieppe.;J Donovan.;T Peters.;J Eachus.;N Pearson.;R Greenwood.;S Frankel.
来源: Rheumatology (Oxford). 2003年42卷4期516-21页
To determine the population requirement for total knee replacement (TKR) in England.
7430. Fibromyalgia and the therapeutic domain. A philosophical study on the origins of fibromyalgia in a specific social setting.
Fibromyalgia has always attracted controversy. Wolfe states that fibromyalgia will always exist regardless of the name given to the syndrome. Hadler describes fibromyalgia as a form of illness behaviour escalated by labelling. However, we believe that fibromyalgia, as other functional somatic syndromes, is not waiting below the surface until it becomes manifest by labelling.
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