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707. After Ebola in West Africa--Unpredictable Risks, Preventable Epidemics.
作者: .;Junerlyn Agua-Agum.;Benedetta Allegranzi.;Archchun Ariyarajah.;R Bruce Aylward.;Isobel M Blake.;Philippe Barboza.;Daniel Bausch.;Richard J Brennan.;Peter Clement.;Pasqualina Coffey.;Anne Cori.;Christl A Donnelly.;Ilaria Dorigatti.;Patrick Drury.;Kara Durski.;Christopher Dye.;Tim Eckmanns.;Neil M Ferguson.;Christophe Fraser.;Erika Garcia.;Tini Garske.;Alex Gasasira.;Céline Gurry.;Esther Hamblion.;Wes Hinsley.;Robert Holden.;David Holmes.;Stéphane Hugonnet.;Giovanna Jaramillo Gutierrez.;Thibaut Jombart.;Edward Kelley.;Ravi Santhana.;Nuha Mahmoud.;Harriet L Mills.;Yasmine Mohamed.;Emmanuel Musa.;Dhamari Naidoo.;Gemma Nedjati-Gilani.;Emily Newton.;Ian Norton.;Pierre Nouvellet.;Devin Perkins.;Mark Perkins.;Steven Riley.;Dirk Schumacher.;Anita Shah.;Minh Tang.;Olivia Varsaneux.;Maria D Van Kerkhove.
来源: N Engl J Med. 2016年375卷6期587-96页 713. Treatment of Fabry's Disease with the Pharmacologic Chaperone Migalastat.
作者: Dominique P Germain.;Derralynn A Hughes.;Kathleen Nicholls.;Daniel G Bichet.;Roberto Giugliani.;William R Wilcox.;Claudio Feliciani.;Suma P Shankar.;Fatih Ezgu.;Hernan Amartino.;Drago Bratkovic.;Ulla Feldt-Rasmussen.;Khan Nedd.;Usama Sharaf El Din.;Charles M Lourenco.;Maryam Banikazemi.;Joel Charrow.;Majed Dasouki.;David Finegold.;Pilar Giraldo.;Ozlem Goker-Alpan.;Nicola Longo.;C Ronald Scott.;Roser Torra.;Ahmad Tuffaha.;Ana Jovanovic.;Stephen Waldek.;Seymour Packman.;Elizabeth Ludington.;Christopher Viereck.;John Kirk.;Julie Yu.;Elfrida R Benjamin.;Franklin Johnson.;David J Lockhart.;Nina Skuban.;Jeff Castelli.;Jay Barth.;Carrolee Barlow.;Raphael Schiffmann.
来源: N Engl J Med. 2016年375卷6期545-55页
Fabry's disease, an X-linked disorder of lysosomal α-galactosidase deficiency, leads to substrate accumulation in multiple organs. Migalastat, an oral pharmacologic chaperone, stabilizes specific mutant forms of α-galactosidase, increasing enzyme trafficking to lysosomes.
714. Fresh versus Frozen Embryos for Infertility in the Polycystic Ovary Syndrome.
作者: Zi-Jiang Chen.;Yuhua Shi.;Yun Sun.;Bo Zhang.;Xiaoyan Liang.;Yunxia Cao.;Jing Yang.;Jiayin Liu.;Daimin Wei.;Ning Weng.;Lifeng Tian.;Cuifang Hao.;Dongzi Yang.;Feng Zhou.;Juanzi Shi.;Yongle Xu.;Jing Li.;Junhao Yan.;Yingying Qin.;Han Zhao.;Heping Zhang.;Richard S Legro.
来源: N Engl J Med. 2016年375卷6期523-33页
The transfer of fresh embryos is generally preferred over the transfer of frozen embryos for in vitro fertilization (IVF), but some evidence suggests that frozen-embryo transfer may improve the live-birth rate and lower the rates of the ovarian hyperstimulation syndrome and pregnancy complications in women with the polycystic ovary syndrome.
715. Randomized Trial of Thymectomy in Myasthenia Gravis.
作者: Gil I Wolfe.;Henry J Kaminski.;Inmaculada B Aban.;Greg Minisman.;Hui-Chien Kuo.;Alexander Marx.;Philipp Ströbel.;Claudio Mazia.;Joel Oger.;J Gabriel Cea.;Jeannine M Heckmann.;Amelia Evoli.;Wilfred Nix.;Emma Ciafaloni.;Giovanni Antonini.;Rawiphan Witoonpanich.;John O King.;Said R Beydoun.;Colin H Chalk.;Alexandru C Barboi.;Anthony A Amato.;Aziz I Shaibani.;Bashar Katirji.;Bryan R F Lecky.;Camilla Buckley.;Angela Vincent.;Elza Dias-Tosta.;Hiroaki Yoshikawa.;Márcia Waddington-Cruz.;Michael T Pulley.;Michael H Rivner.;Anna Kostera-Pruszczyk.;Robert M Pascuzzi.;Carlayne E Jackson.;Guillermo S Garcia Ramos.;Jan J G M Verschuuren.;Janice M Massey.;John T Kissel.;Lineu C Werneck.;Michael Benatar.;Richard J Barohn.;Rup Tandan.;Tahseen Mozaffar.;Robin Conwit.;Joanne Odenkirchen.;Joshua R Sonett.;Alfred Jaretzki.;John Newsom-Davis.;Gary R Cutter.; .
来源: N Engl J Med. 2016年375卷6期511-22页
Thymectomy has been a mainstay in the treatment of myasthenia gravis, but there is no conclusive evidence of its benefit. We conducted a multicenter, randomized trial comparing thymectomy plus prednisone with prednisone alone.
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