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642. Disclosing Pleiotropic Effects During Genetic Risk Assessment for Alzheimer Disease: A Randomized Trial.
作者: Kurt D Christensen.;J Scott Roberts.;Peter J Whitehouse.;Charmaine D M Royal.;Thomas O Obisesan.;L Adrienne Cupples.;Jacqueline A Vernarelli.;Deepak L Bhatt.;Erin Linnenbringer.;Melissa B Butson.;Grace-Ann Fasaye.;Wendy R Uhlmann.;Susan Hiraki.;Na Wang.;Robert Cook-Deegan.;Robert C Green.; .
来源: Ann Intern Med. 2016年164卷3期155-63页
Increasing use of genetic testing raises questions about disclosing secondary findings, including pleiotropic information.
644. Sharing Clinical Trial Data: A Proposal From the International Committee of Medical Journal Editors.
作者: Darren B Taichman.;Joyce Backus.;Christopher Baethge.;Howard Bauchner.;Peter W de Leeuw.;Jeffrey M Drazen.;John Fletcher.;Frank A Frizelle.;Trish Groves.;Abraham Haileamlak.;Astrid James.;Christine Laine.;Larry Peiperl.;Anja Pinborg.;Peush Sahni.;Sinan Wu.
来源: Ann Intern Med. 2016年164卷7期505-6页 645. Appropriate Antibiotic Use for Acute Respiratory Tract Infection in Adults: Advice for High-Value Care From the American College of Physicians and the Centers for Disease Control and Prevention.
Acute respiratory tract infection (ARTI) is the most common reason for antibiotic prescription in adults. Antibiotics are often inappropriately prescribed for patients with ARTI. This article presents best practices for antibiotic use in healthy adults (those without chronic lung disease or immunocompromising conditions) presenting with ARTI.
649. Acupuncture for Menopausal Hot Flashes: A Randomized Trial.
作者: Carolyn Ee.;Charlie Xue.;Patty Chondros.;Stephen P Myers.;Simon D French.;Helena Teede.;Marie Pirotta.
来源: Ann Intern Med. 2016年164卷3期146-54页
Hot flashes (HFs) affect up to 75% of menopausal women and pose a considerable health and financial burden. Evidence of acupuncture efficacy as an HF treatment is conflicting.
650. Laparoscopic Lavage for Perforated Diverticulitis With Purulent Peritonitis: A Randomized Trial.
作者: Anders Thornell.;Eva Angenete.;Thue Bisgaard.;David Bock.;Jakob Burcharth.;Jane Heath.;Hans-Christian Pommergaard.;Jacob Rosenberg.;Nikolaj Stilling.;Stefan Skullman.;Eva Haglind.
来源: Ann Intern Med. 2016年164卷3期137-45页
Perforated diverticulitis with purulent peritonitis has traditionally been treated with open colon resection and stoma formation with risk for reoperations, morbidity, and mortality. Laparoscopic lavage alone has been suggested as definitive treatment.
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