533. Endemic Scrub Typhus in South America.
作者: Thomas Weitzel.;Sabine Dittrich.;Javier López.;Weerawat Phuklia.;Constanza Martinez-Valdebenito.;Katia Velásquez.;Stuart D Blacksell.;Daniel H Paris.;Katia Abarca.
来源: N Engl J Med. 2016年375卷10期954-61页
Scrub typhus is a life-threatening zoonosis caused by Orientia tsutsugamushi organisms that are transmitted by the larvae of trombiculid mites. Endemic scrub typhus was originally thought to be confined to the so called "tsutsugamushi triangle" within the Asia-Pacific region. In 2006, however, two individual cases were detected in the Middle East and South America, which suggested that the pathogen was present farther afield. Here, we report three autochthonous cases of scrub typhus caused by O. tsutsugamushi acquired on Chiloé Island in southern Chile, which suggests the existence of an endemic focus in South America. (Funded by the Chilean Comisión Nacional de Investigación Científica y Tecnológica and the Wellcome Trust.).
534. Cord-Blood Transplantation in Patients with Minimal Residual Disease.
作者: Filippo Milano.;Ted Gooley.;Brent Wood.;Ann Woolfrey.;Mary E Flowers.;Kristine Doney.;Robert Witherspoon.;Marco Mielcarek.;Joachim H Deeg.;Mohamed Sorror.;Ann Dahlberg.;Brenda M Sandmaier.;Rachel Salit.;Effie Petersdorf.;Frederick R Appelbaum.;Colleen Delaney.
来源: N Engl J Med. 2016年375卷10期944-53页
The majority of patients in need of a hematopoietic-cell transplant do not have a matched related donor. Data are needed to inform the choice among various alternative donor-cell sources.
535. Adalimumab in Patients with Active Noninfectious Uveitis.
作者: Glenn J Jaffe.;Andrew D Dick.;Antoine P Brézin.;Quan Dong Nguyen.;Jennifer E Thorne.;Philippe Kestelyn.;Talin Barisani-Asenbauer.;Pablo Franco.;Arnd Heiligenhaus.;David Scales.;David S Chu.;Anne Camez.;Nisha V Kwatra.;Alexandra P Song.;Martina Kron.;Samir Tari.;Eric B Suhler.
来源: N Engl J Med. 2016年375卷10期932-43页
Patients with noninfectious uveitis are at risk for long-term complications of uncontrolled inflammation, as well as for the adverse effects of long-term glucocorticoid therapy. We conducted a trial to assess the efficacy and safety of adalimumab as a glucocorticoid-sparing agent for the treatment of noninfectious uveitis.
540. Trial of Decompressive Craniectomy for Traumatic Intracranial Hypertension.
作者: Peter J Hutchinson.;Angelos G Kolias.;Ivan S Timofeev.;Elizabeth A Corteen.;Marek Czosnyka.;Jake Timothy.;Ian Anderson.;Diederik O Bulters.;Antonio Belli.;C Andrew Eynon.;John Wadley.;A David Mendelow.;Patrick M Mitchell.;Mark H Wilson.;Giles Critchley.;Juan Sahuquillo.;Andreas Unterberg.;Franco Servadei.;Graham M Teasdale.;John D Pickard.;David K Menon.;Gordon D Murray.;Peter J Kirkpatrick.; .
来源: N Engl J Med. 2016年375卷12期1119-30页
The effect of decompressive craniectomy on clinical outcomes in patients with refractory traumatic intracranial hypertension remains unclear.
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