517. Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy.
作者: Christian Templin.;Jelena R Ghadri.;Johanna Diekmann.;L Christian Napp.;Dana R Bataiosu.;Milosz Jaguszewski.;Victoria L Cammann.;Annahita Sarcon.;Verena Geyer.;Catharina A Neumann.;Burkhardt Seifert.;Jens Hellermann.;Moritz Schwyzer.;Katharina Eisenhardt.;Josef Jenewein.;Jennifer Franke.;Hugo A Katus.;Christof Burgdorf.;Heribert Schunkert.;Christian Moeller.;Holger Thiele.;Johann Bauersachs.;Carsten Tschöpe.;Heinz-Peter Schultheiss.;Charles A Laney.;Lawrence Rajan.;Guido Michels.;Roman Pfister.;Christian Ukena.;Michael Böhm.;Raimund Erbel.;Alessandro Cuneo.;Karl-Heinz Kuck.;Claudius Jacobshagen.;Gerd Hasenfuss.;Mahir Karakas.;Wolfgang Koenig.;Wolfgang Rottbauer.;Samir M Said.;Ruediger C Braun-Dullaeus.;Florim Cuculi.;Adrian Banning.;Thomas A Fischer.;Tuija Vasankari.;K E Juhani Airaksinen.;Marcin Fijalkowski.;Andrzej Rynkiewicz.;Maciej Pawlak.;Grzegorz Opolski.;Rafal Dworakowski.;Philip MacCarthy.;Christoph Kaiser.;Stefan Osswald.;Leonarda Galiuto.;Filippo Crea.;Wolfgang Dichtl.;Wolfgang M Franz.;Klaus Empen.;Stephan B Felix.;Clément Delmas.;Olivier Lairez.;Paul Erne.;Jeroen J Bax.;Ian Ford.;Frank Ruschitzka.;Abhiram Prasad.;Thomas F Lüscher.
来源: N Engl J Med. 2015年373卷10期929-38页
The natural history, management, and outcome of takotsubo (stress) cardiomyopathy are incompletely understood.
518. Telomerase Inhibitor Imetelstat in Patients with Essential Thrombocythemia.
作者: Gabriela M Baerlocher.;Elisabeth Oppliger Leibundgut.;Oliver G Ottmann.;Gary Spitzer.;Olatoyosi Odenike.;Michael A McDevitt.;Alexander Röth.;Michael Daskalakis.;Bart Burington.;Monic Stuart.;David S Snyder.
来源: N Engl J Med. 2015年373卷10期920-8页
Imetelstat, a 13-mer oligonucleotide that is covalently modified with lipid extensions, competitively inhibits telomerase enzymatic activity. It has been shown to inhibit megakaryocytic proliferation in vitro in cells obtained from patients with essential thrombocythemia. In this phase 2 study, we investigated whether imetelstat could elicit hematologic and molecular responses in patients with essential thrombocythemia who had not had a response to or who had had unacceptable side effects from prior therapies.
519. A Pilot Study of the Telomerase Inhibitor Imetelstat for Myelofibrosis.
作者: Ayalew Tefferi.;Terra L Lasho.;Kebede H Begna.;Mrinal M Patnaik.;Darci L Zblewski.;Christy M Finke.;Rebecca R Laborde.;Emnet Wassie.;Lauren Schimek.;Curtis A Hanson.;Naseema Gangat.;Xiaolin Wang.;Animesh Pardanani.
来源: N Engl J Med. 2015年373卷10期908-19页
Current drugs for myeloproliferative neoplasm-associated myelofibrosis, including Janus kinase (JAK) inhibitors, do not induce complete or partial remissions. Imetelstat is a 13-mer lipid-conjugated oligonucleotide that targets the RNA template of human telomerase reverse transcriptase.
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