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481. A call to action and a lifecourse strategy to address the global burden of raised blood pressure on current and future generations: the Lancet Commission on hypertension.
作者: Michael H Olsen.;Sonia Y Angell.;Samira Asma.;Pierre Boutouyrie.;Dylan Burger.;Julio A Chirinos.;Albertino Damasceno.;Christian Delles.;Anne-Paule Gimenez-Roqueplo.;Dagmara Hering.;Patricio López-Jaramillo.;Fernando Martinez.;Vlado Perkovic.;Ernst R Rietzschel.;Giuseppe Schillaci.;Aletta E Schutte.;Angelo Scuteri.;James E Sharman.;Kristian Wachtell.;Ji Guang Wang.
来源: Lancet. 2016年388卷10060期2665-2712页 487. Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials.
作者: Nicholas J Viney.;Julian C van Capelleveen.;Richard S Geary.;Shuting Xia.;Joseph A Tami.;Rosie Z Yu.;Santica M Marcovina.;Steven G Hughes.;Mark J Graham.;Rosanne M Crooke.;Stanley T Crooke.;Joseph L Witztum.;Erik S Stroes.;Sotirios Tsimikas.
来源: Lancet. 2016年388卷10057期2239-2253页
Elevated lipoprotein(a) (Lp[a]) is a highly prevalent (around 20% of people) genetic risk factor for cardiovascular disease and calcific aortic valve stenosis, but no approved specific therapy exists to substantially lower Lp(a) concentrations. We aimed to assess the efficacy, safety, and tolerability of two unique antisense oligonucleotides designed to lower Lp(a) concentrations.
489. Measuring the health-related Sustainable Development Goals in 188 countries: a baseline analysis from the Global Burden of Disease Study 2015.
In September, 2015, the UN General Assembly established the Sustainable Development Goals (SDGs). The SDGs specify 17 universal goals, 169 targets, and 230 indicators leading up to 2030. We provide an analysis of 33 health-related SDG indicators based on the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015).
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