当前位置: 首页 >> 检索结果
435. Plasma osteopontin is a biomarker for the severity of alcoholic liver cirrhosis, not for hepatocellular carcinoma screening.
作者: Adélia Simão.;João Madaleno.;Nuno Silva.;Fernando Rodrigues.;Paula Caseiro.;José Nascimento Costa.;Armando Carvalho.
来源: BMC Gastroenterol. 2015年15卷73页
Implementation of surveillance programs for at-risk populations and identification of biomarkers for early hepatocellular carcinoma (HCC) detection are a major public health goal. Recently, osteopontin (OPN) has attracted attention as a promising biomarker, with some potential advantages compared to alpha-fetoprotein (AFP), but its role in the context of alcoholic cirrhosis has never been assessed. The aims of this study are to assess the utility of plasma OPN in the diagnosis of HCC in alcoholic cirrhotic patients and to investigate whether increased values are due to the tumor or underlying liver disease severity.
436. Relation of cholesterol metabolism to pediatric gallstone disease: a retrospective controlled study.
作者: Antti Koivusalo.;Mikko Pakarinen.;Helena Gylling.;Markku J Nissinen.
来源: BMC Gastroenterol. 2015年15卷74页
Cholesterol metabolism may be involved in pediatric gallstone disease. We aimed to reveal cholesterol metabolites and phytosterols and their relation to stone composition of sterols in children having black pigment and cholesterol stones.
437. Physician Non-adherence to Colonoscopy Interval Guidelines in the Veterans Affairs Healthcare System.
作者: Marcus R Johnson.;Janet Grubber.;Steven C Grambow.;Matthew L Maciejewski.;Tyra Dunn-Thomas.;Dawn Provenzale.;Deborah A Fisher.
来源: Gastroenterology. 2015年149卷4期938-51页
Colonoscopy can decrease colorectal cancer (CRC) mortality, although performing this procedure more frequently than recommended could increase costs and risks to patients. We aimed to determine rates and correlates of physician non-adherence to guidelines for repeat colonoscopy screening and polyp surveillance intervals.
438. Exome Sequencing Reveals Germline SMAD9 Mutation That Reduces Phosphatase and Tensin Homolog Expression and Is Associated With Hamartomatous Polyposis and Gastrointestinal Ganglioneuromas.
作者: Joanne Ngeow.;Wanfeng Yu.;Lamis Yehia.;Farshad Niazi.;Jinlian Chen.;Xuhua Tang.;Brandie Heald.;Junying Lei.;Todd Romigh.;Lisa Tucker-Kellogg.;Kiat Hon Lim.;Haiwei Song.;Charis Eng.
来源: Gastroenterology. 2015年149卷4期886-9.e5页
Hamartomatous polyposis syndromes (HPS) account for a small but appreciable proportion of inherited gastrointestinal cancer predisposition syndromes; patients with HPS have an increased risk for colon and extracolonic malignancies. We present a unique case of familial juvenile polyposis syndrome associated with gastrointestinal ganglioneuromas of unknown etiology. The patient was tested for HPS-associated genes, but no mutation was detected. Exome sequencing identified a germline heterozygous mutation in SMAD9 (SMAD9(V90M)). This mutation was predicted to be an activating mutation. HEK cells transfected to express SMAD9(V90M) had reduced expression of phosphatase and tensin homolog; this reduction was also observed in a polyp from the patient. We have therefore identified a new susceptibility locus for HPS. Patients with hamartomatous polyposis in the colon associated with ganglioneuromatosis should be referred for genetic assessments.
|