当前位置: 首页 >> 检索结果
21. An intensified dosing schedule of subcutaneous methotrexate in patients with moderate to severe plaque-type psoriasis (METOP): a 52 week, multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.
作者: Richard B Warren.;Ulrich Mrowietz.;Ralph von Kiedrowski.;Johannes Niesmann.;Dagmar Wilsmann-Theis.;Kamran Ghoreschi.;Ina Zschocke.;Thomas M Falk.;Norbert Blödorn-Schlicht.;Kristian Reich.
来源: Lancet. 2017年389卷10068期528-537页
Methotrexate is one of the most commonly used systemic drugs for the treatment of moderate to severe psoriasis; however, high-quality evidence for its use is sparse and limited to use of oral dosing. We aimed to assess the effect of an intensified dosing schedule of subcutaneous methotrexate in patients with moderate to severe plaque-type psoriasis.
24. Pelvic floor muscle training for secondary prevention of pelvic organ prolapse (PREVPROL): a multicentre randomised controlled trial.
作者: Suzanne Hagen.;Cathryn Glazener.;Doreen McClurg.;Christine Macarthur.;Andrew Elders.;Peter Herbison.;Don Wilson.;Philip Toozs-Hobson.;Christine Hemming.;Jean Hay-Smith.;Marissa Collins.;Sylvia Dickson.;Janet Logan.
来源: Lancet. 2017年389卷10067期393-402页
Pelvic floor muscle training can reduce prolapse severity and symptoms in women seeking treatment. We aimed to assess whether this intervention could also be effective in secondary prevention of prolapse and the need for future treatment.
25. Adverse events after first, single, mesh and non-mesh surgical procedures for stress urinary incontinence and pelvic organ prolapse in Scotland, 1997-2016: a population-based cohort study.
作者: Joanne R Morling.;David A McAllister.;Wael Agur.;Colin M Fischbacher.;Cathryn M A Glazener.;Karen Guerrero.;Leanne Hopkins.;Rachael Wood.
来源: Lancet. 2017年389卷10069期629-640页
Concerns have been raised about the safety of surgery for stress urinary incontinence and pelvic organ prolapse using transvaginal mesh. We assessed adverse outcomes after first, single mesh procedures and comparable non-mesh procedures.
29. Mesh, graft, or standard repair for women having primary transvaginal anterior or posterior compartment prolapse surgery: two parallel-group, multicentre, randomised, controlled trials (PROSPECT).
作者: Cathryn Ma Glazener.;Suzanne Breeman.;Andrew Elders.;Christine Hemming.;Kevin G Cooper.;Robert M Freeman.;Anthony Rb Smith.;Fiona Reid.;Suzanne Hagen.;Isobel Montgomery.;Mary Kilonzo.;Dwayne Boyers.;Alison McDonald.;Gladys McPherson.;Graeme MacLennan.;John Norrie.; .
来源: Lancet. 2017年389卷10067期381-392页
The use of transvaginal mesh and biological graft material in prolapse surgery is controversial and has led to a number of enquiries into their safety and efficacy. Existing trials of these augmentations are individually too small to be conclusive. We aimed to compare the outcomes of prolapse repair involving either synthetic mesh inlays or biological grafts against standard repair in women.
32. Home use of a bihormonal bionic pancreas versus insulin pump therapy in adults with type 1 diabetes: a multicentre randomised crossover trial.
作者: Firas H El-Khatib.;Courtney Balliro.;Mallory A Hillard.;Kendra L Magyar.;Laya Ekhlaspour.;Manasi Sinha.;Debbie Mondesir.;Aryan Esmaeili.;Celia Hartigan.;Michael J Thompson.;Samir Malkani.;J Paul Lock.;David M Harlan.;Paula Clinton.;Eliana Frank.;Darrell M Wilson.;Daniel DeSalvo.;Lisa Norlander.;Trang Ly.;Bruce A Buckingham.;Jamie Diner.;Milana Dezube.;Laura A Young.;April Goley.;M Sue Kirkman.;John B Buse.;Hui Zheng.;Rajendranath R Selagamsetty.;Edward R Damiano.;Steven J Russell.
来源: Lancet. 2017年389卷10067期369-380页
The safety and effectiveness of a continuous, day-and-night automated glycaemic control system using insulin and glucagon has not been shown in a free-living, home-use setting. We aimed to assess whether bihormonal bionic pancreas initialised only with body mass can safely reduce mean glycaemia and hypoglycaemia in adults with type 1 diabetes who were living at home and participating in their normal daily routines without restrictions on diet or physical activity.
|