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21. Presence of commensal house dust mite allergen in human gastrointestinal tract: a potential contributor to intestinal barrier dysfunction.
作者: Meri K Tulic.;Mylene Vivinus-Nébot.;Akila Rekima.;Samara Rabelo Medeiros.;Chrystelle Bonnart.;Haining Shi.;Allan Walker.;Raffaella Dainese.;Julien Boyer.;Nathalie Vergnolle.;Thierry Piche.;Valérie Verhasselt.
来源: Gut. 2016年65卷5期757-66页
Abnormal gut barrier function is the basis of gut inflammatory disease. It is known that house dust mite (HDM) aero-allergens induce inflammation in respiratory mucosa. We have recently reported allergen from Dermatophagoides pteronyssinus (Der p1) to be present in rodent gut.
22. Validation of the Inflammatory Bowel Disease Disability Index in a population-based cohort.
作者: Corinne Gower-Rousseau.;Hélène Sarter.;Guillaume Savoye.;Noémie Tavernier.;Mathurin Fumery.;William J Sandborn.;Brian G Feagan.;Alain Duhamel.;Nathalie Guillon-Dellac.;Jean-Frédéric Colombel.;Laurent Peyrin-Biroulet.; .; .
来源: Gut. 2017年66卷4期588-596页
IBDs are chronic destructive disorders that negatively affect the functional status of patients. Recently, the Inflammatory Bowel Disease Disability Index (IBD-DI) was developed according to standard WHO processes. The aims of the current study were to validate the IBD-DI in an independent patient cohort, to develop an index-specific scoring system and to describe the disability status of a well-defined population-based cohort of French patients with IBD.
23. The rs2296651 (S267F) variant on NTCP (SLC10A1) is inversely associated with chronic hepatitis B and progression to cirrhosis and hepatocellular carcinoma in patients with chronic hepatitis B.
作者: Hui-Han Hu.;Jessica Liu.;Yu-Ling Lin.;Wun-Sheng Luo.;Yu-Ju Chu.;Chia-Lin Chang.;Chin-Lan Jen.;Mei-Hsuan Lee.;Sheng-Nan Lu.;Li-Yu Wang.;San-Lin You.;Hwai-I Yang.;Chien-Jen Chen.; .
来源: Gut. 2016年65卷9期1514-21页
The sodium taurocholate co-transporting polypeptide (NTCP), encoded by SLC10A1, was recently identified as a receptor for HBV. We assessed the association of the p.Ser267Phe variant (rs2296651) with chronic hepatitis B (CHB) serostatus, cirrhosis and hepatocellular carcinoma (HCC) in patients with CHB.
24. Caffeine protects against experimental acute pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ release.
作者: Wei Huang.;Matthew C Cane.;Rajarshi Mukherjee.;Peter Szatmary.;Xiaoying Zhang.;Victoria Elliott.;Yulin Ouyang.;Michael Chvanov.;Diane Latawiec.;Li Wen.;David M Booth.;Andrea C Haynes.;Ole H Petersen.;Alexei V Tepikin.;David N Criddle.;Robert Sutton.
来源: Gut. 2017年66卷2期301-313页
Caffeine reduces toxic Ca2+ signals in pancreatic acinar cells via inhibition of inositol 1,4,5-trisphosphate receptor (IP3R)-mediated signalling, but effects of other xanthines have not been evaluated, nor effects of xanthines on experimental acute pancreatitis (AP). We have determined effects of caffeine and its xanthine metabolites on pancreatic acinar IP3R-mediated Ca2+ signalling and experimental AP.
25. Intestinal microbiota contributes to individual susceptibility to alcoholic liver disease.
作者: M Llopis.;A M Cassard.;L Wrzosek.;L Boschat.;A Bruneau.;G Ferrere.;V Puchois.;J C Martin.;P Lepage.;T Le Roy.;L Lefèvre.;B Langelier.;F Cailleux.;A M González-Castro.;S Rabot.;F Gaudin.;H Agostini.;S Prévot.;D Berrebi.;D Ciocan.;C Jousse.;S Naveau.;P Gérard.;G Perlemuter.
来源: Gut. 2016年65卷5期830-9页
There is substantial inter-individual diversity in the susceptibility of alcoholics to liver injury. Alterations of intestinal microbiota (IM) have been reported in alcoholic liver disease (ALD), but the extent to which they are merely a consequence or a cause is unknown. We aimed to demonstrate that a specific dysbiosis contributes to the development of alcoholic hepatitis (AH).
27. Reduced risk of pancreatic cancer associated with asthma and nasal allergies.
作者: Paulina Gomez-Rubio.;Jan-Paul Zock.;Marta Rava.;Mirari Marquez.;Linda Sharp.;Manuel Hidalgo.;Alfredo Carrato.;Lucas Ilzarbe.;Christoph Michalski.;Xavier Molero.;Antoni Farré.;José Perea.;William Greenhalf.;Michael O'Rorke.;Adonina Tardón.;Thomas Gress.;Victor Barberà.;Tatjana Crnogorac-Jurcevic.;Enrique Domínguez-Muñoz.;Luís Muñoz-Bellvís.;Cristina Alvarez-Urturi.;Joaquim Balcells.;Luis Barneo.;Eithne Costello.;Carmen Guillén-Ponce.;Jörg Kleeff.;Bo Kong.;Rita Lawlor.;Matthias Löhr.;Josefina Mora.;Lim Murray.;Damian O'Driscoll.;Pablo Peláez.;Ignasi Poves.;Aldo Scarpa.;Francisco X Real.;Núria Malats.; .
来源: Gut. 2017年66卷2期314-322页
Studies indicate an inverse association between ductal adenocarcinoma of the pancreas (PDAC) and nasal allergies. However, controversial findings are reported for the association with asthma. Understanding PDAC risk factors will help us to implement appropriate strategies to prevent, treat and diagnose this cancer. This study assessed and characterised the association between PDAC and asthma and corroborated existing reports regarding the association between allergies and PDAC risk.
28. Structural robustness of the gut mucosal microbiota is associated with Crohn's disease remission after surgery.
作者: S Mondot.;P Lepage.;P Seksik.;M Allez.;X Tréton.;Y Bouhnik.;J F Colombel.;M Leclerc.;P Pochart.;J Doré.;P Marteau.; .
来源: Gut. 2016年65卷6期954-62页
Preventing postoperative recurrence after ileocolonic resection (ICR) for Crohn's disease (CD) is challenging. Defining the disturbances of the microbial composition and community structure after ICR and their link with early disease recurrence is crucial.
29. Long-term results of the European achalasia trial: a multicentre randomised controlled trial comparing pneumatic dilation versus laparoscopic Heller myotomy.
作者: An Moonen.;Vito Annese.;Ann Belmans.;Albert J Bredenoord.;Stanislas Bruley des Varannes.;Mario Costantini.;Bertrand Dousset.;J I Elizalde.;Uberto Fumagalli.;Marianne Gaudric.;Antonio Merla.;Andre J Smout.;Jan Tack.;Giovanni Zaninotto.;Olivier R Busch.;Guy E Boeckxstaens.
来源: Gut. 2016年65卷5期732-9页
Achalasia is a chronic motility disorder of the oesophagus for which laparoscopic Heller myotomy (LHM) and endoscopic pneumodilation (PD) are the most commonly used treatments. However, prospective data comparing their long-term efficacy is lacking.
32. Detection of gluten immunogenic peptides in the urine of patients with coeliac disease reveals transgressions in the gluten-free diet and incomplete mucosal healing.
作者: María de Lourdes Moreno.;Ángel Cebolla.;Alba Muñoz-Suano.;Carolina Carrillo-Carrion.;Isabel Comino.;Ángeles Pizarro.;Francisco León.;Alfonso Rodríguez-Herrera.;Carolina Sousa.
来源: Gut. 2017年66卷2期250-257页
Gluten-free diet (GFD) is the only management for coeliac disease (CD). Available methods to assess GFD compliance are insufficiently sensitive to detect occasional dietary transgressions that may cause gut mucosal damage. We aimed to develop a method to determine gluten intake and monitor GFD compliance in patients with CD and to evaluate its correlation with mucosal damage.
34. Clinical risk factors of colorectal cancer in patients with serrated polyposis syndrome: a multicentre cohort analysis.
作者: J E G IJspeert.;S A Q Rana.;N S S Atkinson.;Y J van Herwaarden.;B A J Bastiaansen.;M E van Leerdam.;S Sanduleanu.;T M Bisseling.;M C W Spaander.;S K Clark.;G A Meijer.;N van Lelyveld.;J J Koornstra.;I D Nagtegaal.;J E East.;A Latchford.;E Dekker.; .
来源: Gut. 2017年66卷2期278-284页
Serrated polyposis syndrome (SPS) is accompanied by an increased risk of colorectal cancer (CRC). Patients fulfilling the clinical criteria, as defined by the WHO, have a wide variation in CRC risk. We aimed to assess risk factors for CRC in a large cohort of patients with SPS and to evaluate the risk of CRC during surveillance.
35. HVR1-mediated antibody evasion of highly infectious in vivo adapted HCV in humanised mice.
作者: Jannick Prentoe.;Lieven Verhoye.;Rodrigo Velázquez Moctezuma.;Caroline Buysschaert.;Ali Farhoudi.;Richard Wang.;Harvey Alter.;Philip Meuleman.;Jens Bukh.
来源: Gut. 2016年65卷12期1988-1997页
HCV is a major cause of chronic liver disease worldwide, but the role of neutralising antibodies (nAbs) in its natural history remains poorly defined. We analysed the in vivo role of hypervariable region 1 (HVR1) for HCV virion properties, including nAb susceptibility.
36. Improving safety of autologous haematopoietic stem cell transplantation in patients with Crohn's disease.
作者: Aranzazu Jauregui-Amezaga.;Montserrat Rovira.;Pedro Marín.;Azucena Salas.;Susana Pinó-Donnay.;Faust Feu.;J Ignasi Elizalde.;Francesc Fernández-Avilés.;Carmen Martínez.;Gonzalo Gutiérrez.;Laura Rosiñol.;Enric Carreras.;Alvaro Urbano.;Miguel Lozano.;Joan Cid.;María Suárez-Lledó.;Josep Mensa.;Jordi Rimola.;Sonia Rodríguez.;Mari Carme Masamunt.;Dolors Comas.;Irene Ruíz.;Anna Ramírez-Morros.;Marta Gallego.;Ingrid Ordás.;Julian Panés.;Elena Ricart.
来源: Gut. 2016年65卷9期1456-62页
To evaluate the feasibility and toxicity of autologous haematopoietic stem cell transplantation (HSCT) for the treatment of refractory Crohn's disease (CD).
37. Efficacy of psychotropic drugs in functional dyspepsia: systematic review and meta-analysis.
作者: Alexander C Ford.;Pavit Luthra.;Jan Tack.;Guy E Boeckxstaens.;Paul Moayyedi.;Nicholas J Talley.
来源: Gut. 2017年66卷3期411-420页
Functional dyspepsia (FD) is a chronic gastroduodenal disorder. Individuals with FD demonstrate visceral hypersensitivity, abnormal central pain processing, and low mood, but it is unclear whether psychotropic drugs are an effective treatment for the condition. We performed a systematic review and meta-analysis of randomised controlled trials (RCTs).
38. Apelin targets gut contraction to control glucose metabolism via the brain.
作者: Audren Fournel.;Anne Drougard.;Thibaut Duparc.;Alysson Marlin.;Stuart M Brierley.;Joel Castro.;Sophie Le-Gonidec.;Bernard Masri.;André Colom.;Alexandre Lucas.;Perrine Rousset.;Nicolas Cenac.;Nathalie Vergnolle.;Philippe Valet.;Patrice D Cani.;Claude Knauf.
来源: Gut. 2017年66卷2期258-269页
The gut-brain axis is considered as a major regulatory checkpoint in the control of glucose homeostasis. The detection of nutrients and/or hormones in the duodenum informs the hypothalamus of the host's nutritional state. This process may occur via hypothalamic neurons modulating central release of nitric oxide (NO), which in turn controls glucose entry into tissues. The enteric nervous system (ENS) modulates intestinal contractions in response to various stimuli, but the importance of this interaction in the control of glucose homeostasis via the brain is unknown. We studied whether apelin, a bioactive peptide present in the gut, regulates ENS-evoked contractions, thereby identifying a new physiological partner in the control of glucose utilisation via the hypothalamus.
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