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23. IL-27: a new target for GVHD prevention.
In this issue of Blood, Belle et al have identified a key role for interleukin-27 (IL-27) in acute graft-versus-host disease (GVHD), which is a complex process orchestrated by donor immune T cells and antigen-presenting cells of both donor and host origin.
24. Inhibitory antibodies against factor VIII C1 domain.
In this issue of Blood, Batsuli et al demonstrate that pathogenic antibodies against the factor VIII (fVIII) C1 domain are more common than previously appreciated and that they can cause bleeding through a novel mechanism.
26. Tense your megas! Structural rigidity is key.
In this issue of Blood, Aguilar et al demonstrate that megakaryocytes adapt to the “stiffness” of their microenvironment and that re-creating the physical constraints encountered in native bone marrow dramatically improves in vitro megakaryocyte differentiation and proplatelet formation.
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