37. Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis.
作者: Dominique Baeten.;Joachim Sieper.;Jürgen Braun.;Xenofon Baraliakos.;Maxime Dougados.;Paul Emery.;Atul Deodhar.;Brian Porter.;Ruvie Martin.;Mats Andersson.;Shephard Mpofu.;Hanno B Richards.; .; .
来源: N Engl J Med. 2015年373卷26期2534-48页
Secukinumab is an anti-interleukin-17A monoclonal antibody that has been shown to control the symptoms of ankylosing spondylitis in a phase 2 trial. We conducted two phase 3 trials of secukinumab in patients with active ankylosing spondylitis.
38. Selexipag for the Treatment of Pulmonary Arterial Hypertension.
作者: Olivier Sitbon.;Richard Channick.;Kelly M Chin.;Aline Frey.;Sean Gaine.;Nazzareno Galiè.;Hossein-Ardeschir Ghofrani.;Marius M Hoeper.;Irene M Lang.;Ralph Preiss.;Lewis J Rubin.;Lilla Di Scala.;Victor Tapson.;Igor Adzerikho.;Jinming Liu.;Olga Moiseeva.;Xiaofeng Zeng.;Gérald Simonneau.;Vallerie V McLaughlin.; .
来源: N Engl J Med. 2015年373卷26期2522-33页
In a phase 2 trial, selexipag, an oral selective IP prostacyclin-receptor agonist, was shown to be beneficial in the treatment of pulmonary arterial hypertension.
39. Azithromycin versus Doxycycline for Urogenital Chlamydia trachomatis Infection.
作者: William M Geisler.;Apurva Uniyal.;Jeannette Y Lee.;Shelly Y Lensing.;Shacondra Johnson.;Raymond C W Perry.;Carmel M Kadrnka.;Peter R Kerndt.
来源: N Engl J Med. 2015年373卷26期2512-21页
Urogenital Chlamydia trachomatis infection remains prevalent and causes substantial reproductive morbidity. Recent studies have raised concern about the efficacy of azithromycin for the treatment of chlamydia infection.
40. Second Cancer Risk Up to 40 Years after Treatment for Hodgkin's Lymphoma.
作者: Michael Schaapveld.;Berthe M P Aleman.;Anna M van Eggermond.;Cécile P M Janus.;Augustinus D G Krol.;Richard W M van der Maazen.;Judith Roesink.;John M M Raemaekers.;Jan Paul de Boer.;Josée M Zijlstra.;Gustaaf W van Imhoff.;Eefke J Petersen.;Philip M P Poortmans.;Max Beijert.;Marnix L Lybeert.;Ina Mulder.;Otto Visser.;Marieke W J Louwman.;Inge M Krul.;Pieternella J Lugtenburg.;Flora E van Leeuwen.
来源: N Engl J Med. 2015年373卷26期2499-511页
Survivors of Hodgkin's lymphoma are at increased risk for treatment-related subsequent malignant neoplasms. The effect of less toxic treatments, introduced in the late 1980s, on the long-term risk of a second cancer remains unknown.
|