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367. Daclizumab HYP versus Interferon Beta-1a in Relapsing Multiple Sclerosis.
作者: Ludwig Kappos.;Heinz Wiendl.;Krzysztof Selmaj.;Douglas L Arnold.;Eva Havrdova.;Alexey Boyko.;Michael Kaufman.;John Rose.;Steven Greenberg.;Marianne Sweetser.;Katherine Riester.;Gilmore O'Neill.;Jacob Elkins.
来源: N Engl J Med. 2015年373卷15期1418-28页
Daclizumab high-yield process (HYP) is a humanized monoclonal antibody that binds to CD25 (alpha subunit of the interleukin-2 receptor) and modulates interleukin-2 signaling. Abnormalities in interleukin-2 signaling have been implicated in the pathogenesis of multiple sclerosis and other autoimmune disorders.
372. Hypothermia for Intracranial Hypertension after Traumatic Brain Injury.
作者: Peter J D Andrews.;H Louise Sinclair.;Aryelly Rodriguez.;Bridget A Harris.;Claire G Battison.;Jonathan K J Rhodes.;Gordon D Murray.; .
来源: N Engl J Med. 2015年373卷25期2403-12页
In patients with traumatic brain injury, hypothermia can reduce intracranial hypertension. The benefit of hypothermia on functional outcome is unclear.
375. Possible Subclinical Leaflet Thrombosis in Bioprosthetic Aortic Valves.
作者: Raj R Makkar.;Gregory Fontana.;Hasan Jilaihawi.;Tarun Chakravarty.;Klaus F Kofoed.;Ole De Backer.;Federico M Asch.;Carlos E Ruiz.;Niels T Olsen.;Alfredo Trento.;John Friedman.;Daniel Berman.;Wen Cheng.;Mohammad Kashif.;Vladimir Jelnin.;Chad A Kliger.;Hongfei Guo.;Augusto D Pichard.;Neil J Weissman.;Samir Kapadia.;Eric Manasse.;Deepak L Bhatt.;Martin B Leon.;Lars Søndergaard.
来源: N Engl J Med. 2015年373卷21期2015-24页
A finding of reduced aortic-valve leaflet motion was noted on computed tomography (CT) in a patient who had a stroke after transcatheter aortic-valve replacement (TAVR) during an ongoing clinical trial. This finding raised a concern about possible subclinical leaflet thrombosis and prompted further investigation.
377. Acetaminophen for Fever in Critically Ill Patients with Suspected Infection.
作者: Paul Young.;Manoj Saxena.;Rinaldo Bellomo.;Ross Freebairn.;Naomi Hammond.;Frank van Haren.;Mark Holliday.;Seton Henderson.;Diane Mackle.;Colin McArthur.;Shay McGuinness.;John Myburgh.;Mark Weatherall.;Steve Webb.;Richard Beasley.; .; .
来源: N Engl J Med. 2015年373卷23期2215-24页
Acetaminophen is a common therapy for fever in patients in the intensive care unit (ICU) who have probable infection, but its effects are unknown.
379. A Multicenter Trial of Remote Ischemic Preconditioning for Heart Surgery.
作者: Patrick Meybohm.;Berthold Bein.;Oana Brosteanu.;Jochen Cremer.;Matthias Gruenewald.;Christian Stoppe.;Mark Coburn.;Gereon Schaelte.;Andreas Böning.;Bernd Niemann.;Jan Roesner.;Frank Kletzin.;Ulrich Strouhal.;Christian Reyher.;Rita Laufenberg-Feldmann.;Marion Ferner.;Ivo F Brandes.;Martin Bauer.;Sebastian N Stehr.;Andreas Kortgen.;Maria Wittmann.;Georg Baumgarten.;Tanja Meyer-Treschan.;Peter Kienbaum.;Matthias Heringlake.;Julika Schön.;Michael Sander.;Sascha Treskatsch.;Thorsten Smul.;Ewa Wolwender.;Thomas Schilling.;Georg Fuernau.;Dirk Hasenclever.;Kai Zacharowski.; .
来源: N Engl J Med. 2015年373卷15期1397-407页
Remote ischemic preconditioning (RIPC) is reported to reduce biomarkers of ischemic and reperfusion injury in patients undergoing cardiac surgery, but uncertainty about clinical outcomes remains.
380. Remote Ischemic Preconditioning and Outcomes of Cardiac Surgery.
作者: Derek J Hausenloy.;Luciano Candilio.;Richard Evans.;Cono Ariti.;David P Jenkins.;Shyam Kolvekar.;Rosemary Knight.;Gudrun Kunst.;Christopher Laing.;Jennifer Nicholas.;John Pepper.;Steven Robertson.;Maria Xenou.;Tim Clayton.;Derek M Yellon.; .
来源: N Engl J Med. 2015年373卷15期1408-17页
Whether remote ischemic preconditioning (transient ischemia and reperfusion of the arm) can improve clinical outcomes in patients undergoing coronary-artery bypass graft (CABG) surgery is not known. We investigated this question in a randomized trial.
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