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341. HNF4α is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer.
作者: Hae Ryung Chang.;Seungyoon Nam.;Myeong-Cherl Kook.;Kyung-Tae Kim.;Xiuping Liu.;Hui Yao.;Hae Rim Jung.;Robert Lemos.;Hye Hyun Seo.;Hee Seo Park.;Youme Gim.;Dongwan Hong.;Iksoo Huh.;Young-Woo Kim.;Dongfeng Tan.;Chang-Gong Liu.;Garth Powis.;Taesung Park.;Han Liang.;Yon Hui Kim.
来源: Gut. 2016年65卷1期19-32页
Worldwide, gastric cancer (GC) is the fourth most common malignancy and the most common cancer in East Asia. Development of targeted therapies for this disease has focused on a few known oncogenes but has had limited effects.
342. Distinct aetiopathogenesis in subgroups of functional dyspepsia according to the Rome III criteria.
作者: Yu-Jen Fang.;Jyh-Ming Liou.;Chieh-Chang Chen.;Ji-Yuh Lee.;Yao-Chun Hsu.;Mei-Jyh Chen.;Ping-Huei Tseng.;Chien-Chuan Chen.;Chi-Yang Chang.;Tsung-Hua Yang.;Wen-Hsiung Chang.;Jeng-Yi Wu.;Hsiu-Po Wang.;Jiing-Chyuan Luo.;Jaw-Town Lin.;Chia-Tung Shun.;Ming-Shiang Wu.; .
来源: Gut. 2015年64卷10期1517-28页
Whether there is distinct pathogenesis in subgroups of functional dyspepsia (FD), the postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS) remains controversial. We aimed to identify the risk factors of FD and its subgroups in the Chinese population.
343. Long-term risk of colorectal cancer in individuals with serrated polyps.
作者: Øyvind Holme.;Michael Bretthauer.;Tor J Eide.;Else Marit Løberg.;Krzysztof Grzyb.;Magnus Løberg.;Mette Kalager.;Hans-Olov Adami.;Øystein Kjellevold.;Geir Hoff.
来源: Gut. 2015年64卷6期929-36页
Although serrated polyps may be precursors of colorectal cancer (CRC), prospective data on the long-term CRC risk in individuals with serrated polyps are lacking.
345. STK33 promotes hepatocellular carcinoma through binding to c-Myc.
作者: Tian Yang.;Bin Song.;Jin Zhang.;Guang-Shun Yang.;Han Zhang.;Wei-Feng Yu.;Meng-Chao Wu.;Jun-Hua Lu.;Feng Shen.
来源: Gut. 2016年65卷1期124-33页
STK33 has been reported to play an important role in cancer cell proliferation. We investigated the role of STK33 in hepatocellular carcinoma (HCC) and its underlying mechanisms.
346. Virtual portal pressure gradient from anatomic CT angiography.
作者: Xiaolong Qi.;Zhiwei Li.;Jiale Huang.;Yanjie Zhu.;Hao Liu.;Fangyu Zhou.;Changchun Liu.;Chaohui Xiao.;Jinghui Dong.;Yongzhao Zhao.;Mingxin Xu.;Surong Xing.;Weiguo Xu.;Changqing Yang.
来源: Gut. 2015年64卷6期1004-5页 347. Association between antiviral treatment and extrahepatic outcomes in patients with hepatitis C virus infection.
作者: Yao-Chun Hsu.;Hsiu J Ho.;Yen-Tsung Huang.;Hsi-Hao Wang.;Ming-Shiang Wu.;Jaw-Town Lin.;Chun-Ying Wu.
来源: Gut. 2015年64卷3期495-503页
To elucidate the association between antiviral therapy and extrahepatic outcomes in individuals infected with HCV.
350. Real-time optical diagnosis for diminutive colorectal polyps using narrow-band imaging: the VALID randomised clinical trial.
作者: Tonya Kaltenbach.;Amit Rastogi.;Robert V Rouse.;Kenneth R McQuaid.;Tohru Sato.;Ajay Bansal.;Jon C Kosek.;Roy Soetikno.
来源: Gut. 2015年64卷10期1569-77页
Diminutive (≤ 5 mm) colorectal polyps are common, and overwhelmingly benign. Routinely, after polypectomy, they are examined pathologically to determine the surveillance intervals. Advances in equipment and techniques, such as narrow-band imaging (NBI) colonoscopy, now permit reliable real-time optical diagnosis.
351. Signatures of tumour immunity distinguish Asian and non-Asian gastric adenocarcinomas.
作者: Suling J Lin.;Johann A Gagnon-Bartsch.;Iain Beehuat Tan.;Sophie Earle.;Louise Ruff.;Katherine Pettinger.;Bauke Ylstra.;Nicole van Grieken.;Sun Young Rha.;Hyun Cheol Chung.;Ju-Seog Lee.;Jae Ho Cheong.;Sung Hoon Noh.;Toru Aoyama.;Yohei Miyagi.;Akira Tsuburaya.;Takaki Yoshikawa.;Jaffer A Ajani.;Alex Boussioutas.;Khay Guan Yeoh.;Wei Peng Yong.;Jimmy So.;Jeeyun Lee.;Won Ki Kang.;Sung Kim.;Yoichi Kameda.;Tomio Arai.;Axel Zur Hausen.;Terence P Speed.;Heike I Grabsch.;Patrick Tan.
来源: Gut. 2015年64卷11期1721-31页
Differences in gastric cancer (GC) clinical outcomes between patients in Asian and non-Asian countries has been historically attributed to variability in clinical management. However, recent international Phase III trials suggest that even with standardised treatments, GC outcomes differ by geography. Here, we investigated gene expression differences between Asian and non-Asian GCs, and if these molecular differences might influence clinical outcome.
352. Demonstration of the usefulness of epigenetic cancer risk prediction by a multicentre prospective cohort study.
作者: Kiyoshi Asada.;Takeshi Nakajima.;Taichi Shimazu.;Nobutake Yamamichi.;Takao Maekita.;Chizu Yokoi.;Ichiro Oda.;Takayuki Ando.;Takeichi Yoshida.;Sohachi Nanjo.;Mitsuhiro Fujishiro.;Takuji Gotoda.;Masao Ichinose.;Toshikazu Ushijima.
来源: Gut. 2015年64卷3期388-96页
Epigenetic alterations accumulate in normal-appearing tissues of patients with cancer, producing an epigenetic field defect. Cross-sectional studies show that the degree of the defect may be associated with risk in some types of cancer, especially cancers associated with chronic inflammation.
353. Caspase-8 controls the gut response to microbial challenges by Tnf-α-dependent and independent pathways.
作者: Claudia Günther.;Barbara Buchen.;Gui-Wei He.;Mathias Hornef.;Natalia Torow.;Helmut Neumann.;Nadine Wittkopf.;Eva Martini.;Marijana Basic.;André Bleich.;Alastair J M Watson.;Markus F Neurath.;Christoph Becker.
来源: Gut. 2015年64卷4期601-10页
Intestinal epithelial cells (IEC) express toll-like receptors (TLR) that facilitate microbial recognition. Stimulation of TLR ligands induces a transient increase in epithelial cell shedding, a mechanism that serves the antibacterial and antiviral host defence of the epithelium and promotes elimination of intracellular pathogens. Although activation of the extrinsic apoptosis pathway has been described during inflammatory shedding, its functional involvement is currently unclear.
355. Epigenetic upregulation of metabotropic glutamate receptor 2 in the spinal cord attenuates oestrogen-induced visceral hypersensitivity.
Epigenetic mechanisms are potential targets to relieve somatic pain. However, little is known whether epigenetic regulation interferes with visceral pain. Previous studies show that oestrogen facilitates visceral pain. This study aimed to determine whether histone hyperacetylation in the spinal cord could attenuate oestrogen-facilitated visceral pain.
357. Strategies for the treatment of Hepatitis C in an era of interferon-free therapies: what public health outcomes do we value most?
The expense of new therapies for HCV infection may force health systems to prioritise the treatment of certain patient groups over others. Our objective was to forecast the population impact of possible prioritisation strategies for the resource-rich setting of Scotland.
359. Early-onset Crohn's disease and autoimmunity associated with a variant in CTLA-4.
作者: Sebastian Zeissig.;Britt-Sabina Petersen.;Michal Tomczak.;Espen Melum.;Emilie Huc-Claustre.;Stephanie K Dougan.;Jon K Laerdahl.;Björn Stade.;Michael Forster.;Stefan Schreiber.;Dascha Weir.;Alan M Leichtner.;Andre Franke.;Richard S Blumberg.
来源: Gut. 2015年64卷12期1889-97页
IBD is a group of complex, systemic disorders associated with intestinal inflammation and extraintestinal manifestations. Recent studies revealed Mendelian forms of IBD, which contributed significantly to our understanding of disease pathogenesis and the heritability of IBD.
360. Reproducibility of histological assessments of disease activity in UC.
作者: Mahmoud H Mosli.;Brian G Feagan.;Guangyong Zou.;William J Sandborn.;Geert D'Haens.;Reena Khanna.;Cynthia Behling.;Keith Kaplan.;David K Driman.;Lisa M Shackelton.;Kenneth A Baker.;John K MacDonald.;Margaret K Vandervoort.;Mark A Samaan.;Karel Geboes.;Mark A Valasek.;Rish Pai.;Cord Langner.;Robert Riddell.;Noam Harpaz.;Maida Sewitch.;Michael Peterson.;Larry W Stitt.;Barrett G Levesque.
来源: Gut. 2015年64卷11期1765-73页
Histopathology is potentially an important outcome measure in UC. Multiple histological disease activity (HA) indices, including the Geboes score (GS) and modified Riley score (MRS), have been developed; however, the operating properties of these instruments are not clearly defined. We assessed the reproducibility of existing measures of HA.
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